Zobrazeno 1 - 10
of 194
pro vyhledávání: '"James D. Doecke"'
Autor:
Xin Huang, Chris Fowler, Yihan Li, Qiao-Xin Li, Jiaqi Sun, Yijun Pan, Liang Jin, Keyla A. Perez, Céline Dubois, Yen Y. Lim, Candace Drysdale, Rebecca L. Rumble, Holly R. Chinnery, Christopher C. Rowe, Ralph N. Martins, Paul Maruff, James D. Doecke, Yong Lin, Abdel A. Belaidi, Kevin J. Barnham, Colin L. Masters, Ben J. Gu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to
Externí odkaz:
https://doaj.org/article/3d0335505eb94001ae1c6a1edbac7289
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
BackgroundComplex disorders, such as Alzheimer’s disease (AD), result from the combined influence of multiple biological and environmental factors. The integration of high-throughput data from multiple omics platforms can provide system overviews,
Externí odkaz:
https://doaj.org/article/1733a2f5fca247f1a4c6a1c9f2a90e35
Autor:
Louise N. Pivac, Belinda M. Brown, Kelsey R. Sewell, James D. Doecke, Victor L. Villemagne, Vincent Doré, Michael Weinborn, Hamid R. Sohrabi, Samantha L. Gardener, Romola S. Bucks, Simon M. Laws, Kevin Taddei, Paul Maruff, Colin L. Masters, Christopher Rowe, Ralph N. Martins, Stephanie R. Rainey‐Smith
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION This study investigated whether self‐reported sleep quality is associated with brain amyloid beta (Aβ) accumulation. METHODS Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (
Externí odkaz:
https://doaj.org/article/752e0f9b15914192953cf6940c065a99
Autor:
Zitianyu Wang, Victoria Lewis, Christiane Stehmann, Shiji Varghese, Matteo Senesi, Amelia McGlade, Laura J. Ellett, James D. Doecke, Dhamidhu Eratne, Dennis Velakoulis, Colin L. Masters, Steven J. Collins, Qiao‐Xin Li
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract Most suspected Creutzfeldt‐Jakob disease (CJD) cases are eventually diagnosed with other disorders. We assessed the utility of investigating Alzheimer's disease (AD) biomarkers and neurofilament light (NfL) in patients when CJD is suspecte
Externí odkaz:
https://doaj.org/article/bb39afaf574a49de915fe1b741f84a76
Autor:
Juliana Muller Bark, Avinash V. Karpe, James D. Doecke, Paul Leo, Rosalind L. Jeffree, Benjamin Chua, Bryan W. Day, David J. Beale, Chamindie Punyadeera
Publikováno v:
Cancer Medicine, Vol 12, Iss 10, Pp 11427-11437 (2023)
Abstract Background Despite aggressive treatment, more than 90% of glioblastoma (GBM) patients experience recurrences. GBM response to therapy is currently assessed by imaging techniques and tissue biopsy. However, difficulties with these methods may
Externí odkaz:
https://doaj.org/article/bf2d3199e1af4d7b9ff4a2375a3e5b34
Autor:
Michael Vacher, Vincent Doré, Tenielle Porter, Lidija Milicic, Victor L. Villemagne, Pierrick Bourgeat, Sam C. Burnham, Timothy Cox, Colin L. Masters, Christopher C. Rowe, Jurgen Fripp, James D. Doecke, Simon M. Laws
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background With a growing number of loci associated with late-onset (sporadic) Alzheimer’s disease (AD), the polygenic contribution to AD is now well established. The development of polygenic risk score approaches have shown promising resu
Externí odkaz:
https://doaj.org/article/922fd30cfa5d4aa2bb78f823a53ae0a8
Autor:
Scott B. Laffoon, James D. Doecke, Anne M. Roberts, Jennifer A. Vance, Benjamin D. Reeves, Kelly K. Pertile, Rebecca L. Rumble, Chris J. Fowler, Brett Trounson, David Ames, Ralph Martins, Ashley I. Bush, Colin L. Masters, Paul A. Grieco, Edward A. Dratz, Blaine R. Roberts
Publikováno v:
Proteome Science, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background The Australian Imaging and Biomarker Lifestyle (AIBL) study of aging is designed to aid the discovery of biomarkers. The current study aimed to discover differentially expressed plasma proteins that could yield a blood-based scree
Externí odkaz:
https://doaj.org/article/b5230de3ca49414eb8a11bef4ca6f19f
Autor:
Matteo Senesi, Victoria Lewis, Shiji Varghese, Christiane Stehmann, Amelia McGlade, James D. Doecke, Laura Ellett, Shannon Sarros, Christopher J. Fowler, Colin L. Masters, Qiao-Xin Li, Steven J. Collins
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
The most frequently utilized biomarkers to support a pre-mortem clinical diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) include concentrations of the 14-3-3 and total tau (T-tau) proteins, as well as the application of protein amplification
Externí odkaz:
https://doaj.org/article/ffbd11a8aac9450a99838a1447b1e0aa
Autor:
Stephan Klatt, James D. Doecke, Anne Roberts, Berin A. Boughton, Colin L. Masters, Malcolm Horne, Blaine R. Roberts
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Characterisation and diagnosis of idiopathic Parkinson’s disease (iPD) is a current challenge that hampers both clinical assessment and clinical trial development with the potential inclusion of non-PD cases. Here, we used a targeted mass
Externí odkaz:
https://doaj.org/article/881b06762bce4c4c9997ee283c5ce1c1
Autor:
Kym McNicholas, Maxime François, Jian-Wei Liu, James D. Doecke, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Tara L. Pukala, Robert A. Rush, Wayne R. Leifert
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is an insidious disease. Its distinctive pathology forms over a considerable length of time without symptoms. There is a need to detect this disease, before even subtle changes occur in cognition. Hallmark AD biomarkers, ta
Externí odkaz:
https://doaj.org/article/dadb710a68054070876f82625da7df16