Zobrazeno 1 - 10
of 53
pro vyhledávání: '"James D. Bergstrom"'
Autor:
James D. Bergstrom
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 8, Pp 100407- (2023)
Acetoacetyl-CoA synthetase (AACS) is the key enzyme in the anabolic utilization of ketone bodies (KBs) for denovo lipid synthesis, a process that bypasses citrate and ATP citrate lyase. This review shows that AACS is a highly regulated, cytosolic, an
Externí odkaz:
https://doaj.org/article/b53590f29c1544da9d5763cdc5811f9c
Autor:
Carol Ann Keohane, Suzanne M. Mandala, Jeffrey J. Hale, Lin Yan, Pei Huo, James A. Milligan, Richard Hajdu, James D. Bergstrom, Gan-Ju Shei, Sander G. Mills, Mark Rosenbach, Gary Chrebet, Deborah Card
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:828-831
Structure–activity relationship (SAR) studies of 3-arylpropionic acids—a class of novel S1P1 selective agonists—by introducing substitution to the propionic acid chain and replacing the adjacent phenyl ring with pyridine led to a series of modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c645e742cfed5468d5b1acfd8e0d6f01
https://doi.org/10.1016/j.bmcl.2006.10.057
https://doi.org/10.1016/j.bmcl.2006.10.057
Autor:
James D. Bergstrom, Zhen Li, Ralph T. Mosley, Gary Chrebet, Paul Fischer, Suzanne M. Mandala, Joseph Clemas, Jeffrey J. Hale, Stephen A. Parent, Sander G. Mills, Qiaolin Deng
Publikováno v:
Molecular Pharmacology. 71:724-735
Sphingosine-1-phosphate (S1P) receptor agonists are novel immunosuppressive agents. The selectivity of S1P1 against S1P3 is strongly correlated with lymphocyte sequestration and minimum acute toxicity and bradycardia. This study describes molecular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ef3f5683c48d6791715c4f4520e80a
https://doi.org/10.1124/mol.106.029223
https://doi.org/10.1124/mol.106.029223
Autor:
Carol Ann Keohane, Suzanne M. Mandala, Mark Rosenbach, Gary Chebret, Gan-Ju Shei, James D. Bergstrom, Vincent J. Colandrea, Irene E. Legiec, Lin Yan, Deborah Card, Pei Huo, James A. Milligan, Sander G. Mills, Richard Hajdu, Jeffrey J. Hale
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2905-2908
A series of 2,5-cis-disubstituted pyrrolidines were synthesized and evaluated as S1P receptor agonists. Compounds 15-21 were identified with good selectivity over S1P3 which lowered circulating lymphocytes after oral administration in mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25b7a036edfd803c546899b5d845e05
https://doi.org/10.1016/j.bmcl.2006.03.038
https://doi.org/10.1016/j.bmcl.2006.03.038
Autor:
Laurie Tota, Suzanne M. Mandala, Gan-Ju Shei, Michael Wright, James D. Bergstrom, Mari R. Candelore, James A. Milligan
Publikováno v:
Biochemical and Biophysical Research Communications. 297:600-606
It has been reported recently that the phosphorylated form of the immunomodulator FTY720 activates sphingosine 1-phosphate G protein-coupled receptors [1] , [2] . Therefore, understanding the biology of this new class of receptors will be important i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88fcd7e895e1aafe7914cb607b0c5c3
https://doi.org/10.1016/s0006-291x(02)02237-4
https://doi.org/10.1016/s0006-291x(02)02237-4
Autor:
JeanMarie Lisnock, Diane Shevell, Daniel J. Rader, Yu-Sheng Chao, John S. Mudgett, Anne Hermanowski-Vosatka, Samuel D. Wright, James D. Bergstrom, Charlotte Burton, Steven S. Mundt, Carl P. Sparrow, Sam Chun, Ellen Puré, Melba Hernandez, Patricia A. Detmers, Renee Weikel, Deborah Card, Heide Hassing, D. S. Fletcher
Publikováno v:
The Journal of Immunology. 165:3430-3435
Inducible NO synthase (iNOS) present in human atherosclerotic plaques could contribute to the inflammatory process of plaque development. The role of iNOS in atherosclerosis was tested directly by evaluating the development of lesions in atherosclero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df5c0b859590d3577459213587eb00f
https://doi.org/10.4049/jimmunol.165.6.3430
https://doi.org/10.4049/jimmunol.165.6.3430
Autor:
James D. Bergstrom, Carl P. Sparrow, Heide Hassing, Anne Hermanowski-Vosatka, Judy Montenegro, Melba Hernandez, Patricia A. Detmers, Samuel D. Wright, Steve Mundt, Charlotte Burton, Yu-Sheng Chao, S. Patel, Deborah Card
Publikováno v:
The Journal of Experimental Medicine
Recent work has revealed correlations between bacterial or viral infections and atherosclerotic disease. One particular bacterium, Chlamydia pneumoniae, has been observed at high frequency in human atherosclerotic lesions, prompting the hypothesis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6caa16bc7342fe8ef1eadd17e4182a9
https://doi.org/10.1084/jem.191.8.1437
https://doi.org/10.1084/jem.191.8.1437
Autor:
Russell B. Lingham, Jackson B. Gibbs, James D. Bergstrom, Rew Dj, Francine R. Wilson, Kim Bm, Samuel L. Graham, Hiranthi Jayasuriya, Kenneth S. Koblan, Sheo B. Singh, Schaber, Amo Se, Keith C. Silverman, Nancy E. Kohl
Publikováno v:
Journal of Medicinal Chemistry. 41:4492-4501
We have identified a novel fungal metabolite that is an inhibitor of human farnesyl-protein transferase (FPTase) by randomly screening natural product extracts using a high-throughput biochemical assay. Clavaric acid [24, 25-dihydroxy-2-(3-hydroxy-3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75e11044c72472b2b24338a1e8c03cc
https://doi.org/10.1021/jm980356+
https://doi.org/10.1021/jm980356+
Autor:
Gerald F. Bills, Marina Mojena, Keith C. Silverman, Leeyuan Huang, Claude Dufresne, Maria S. Meinz, Manuel Sanchez, Jackson B. Gibbs, James D. Bergstrom, John D. Karkas, Sheo B. Singh, Mary Nallin-Omstead, Russell B. Lingham, Guy H. Harris, Wendy H. Clapp
Publikováno v:
Canadian Journal of Botany. 73:898-906
Several potent inhibitors of squalence synthetase have been discovered. Zaragozic acid A is produced by several fungi; zaragozic acid B is produced by several strains of Sporormiella intermedia; zaragozic acids C, E, and F are produced by Leptodontid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7476c44aa960f618b56e68edc9a19f7
https://doi.org/10.1139/b95-337
https://doi.org/10.1139/b95-337
Autor:
Leslie A. Koch, Claude Dufresne, Kent E. Göklen, Deborah L. Zink, James D. Bergstrom, Kenneth E. Wilson, Henry Joshua, Guy H. Harris, Deborah J. Rew, P. Salmon, Marc M. Kurtz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2403-2408
Two new alkyl citrates, L-731,120 and L-731,128, with alkyl chains corresponding to those of zaragozic acids A and B, were isolated as minor components of large scale fungal fermentations producing zaragozic acid A and B. They are submicromolar inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a03734c6c7fa4bde86fed35295fcc7c2
https://doi.org/10.1016/0960-894x(95)00419-t
https://doi.org/10.1016/0960-894x(95)00419-t