Zobrazeno 1 - 10
of 311
pro vyhledávání: '"James D. Marks"'
Autor:
Alexandra B. Steverson, MD, MPH, Paul J. Marano, MD, Caren Chen, MPH, Yifei Ma, MS, Rachel J. Stern, MD, Jean Feng, MS, PhD, Efstathios D. Gennatas, MBBS, PhD, James D. Marks, MD, PhD, Matthew S. Durstenfeld, MD, MAS, Jonathan D. Davis, MD, MPHS, Priscilla Y. Hsue, MD, Lucas S. Zier, MD, MS
Publikováno v:
American Journal of Medicine Open, Vol 10, Iss , Pp 100060- (2023)
Introduction: Heart failure (HF) is a frequent cause of readmissions. Despite caring for underresourced patients and dependence on government funding, safety net hospitals frequently incur penalties for failing to meet pay-for-performance readmission
Externí odkaz:
https://doaj.org/article/8412fd4464a642a7b3a37c3dc292fd91
Autor:
Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Publikováno v:
Toxins, Vol 15, Iss 5, p 316 (2023)
Equine-derived antitoxin (BAT®) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT® is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable
Externí odkaz:
https://doaj.org/article/276c0b76216c46e0a1b5bb0297a8d1eb
Autor:
Yongfeng Fan, Zhengda Sun, Fraser Conrad, Weihua Wen, Lequn Zhao, Jianlong Lou, Yu Zhou, Shauna Farr-Jones, James D Marks
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273512 (2022)
Generating specific monoclonal antibodies (mAbs) that neutralize multiple antigen variants is challenging. Here, we present a strategy to generate mAbs that bind seven subtypes of botulinum neurotoxin serotype F (BoNT/F) that differ from each other i
Externí odkaz:
https://doaj.org/article/7144f5bc7dae452e9022a675df09d5ef
Autor:
Consuelo Garcia-Rodriguez, Shude Yan, Isin N. Geren, Kristeene A. Knopp, Jianbo Dong, Zhengda Sun, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Publikováno v:
Toxins, Vol 13, Iss 9, p 641 (2021)
Human botulism can be caused by botulinum neurotoxin (BoNT) serotypes A to G. Here, we present an antibody-based antitoxin composed of four human monoclonal antibodies (mAbs) against BoNT/C, BoNT/D, and their mosaic toxins. This work built on our suc
Externí odkaz:
https://doaj.org/article/a25047536f784a189fd6ca0fc69595fc
Autor:
Milan T. Tomic, Shauna Farr-Jones, Emily S. Syar, Nancy Niemuth, Dean Kobs, Michael J. Hackett, Yero Espinoza, Zacchary Martinez, Khanh Pham, Doris M. Snow, James D. Marks, Ronald R. Cobb
Publikováno v:
Toxins, Vol 13, Iss 9, p 671 (2021)
Botulinum neurotoxins (BoNT) are some of the most toxic proteins known and can induce respiratory failure requiring long-term intensive care. Treatment of botulism includes the administration of antitoxins. Monoclonal antibodies (mAbs) hold considera
Externí odkaz:
https://doaj.org/article/afc6f9a7ac414c809cee02b1394deb17
Autor:
Anna M. Wu, James D. Marks, Yu Zhou, Parag Mallick, Shannon M. Mumenthaler, Kirstin A. Zettlitz, Richard Tavaré, Keyu Li
Supplementary methods not included in the primary manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d723b52a3859deb0f184d32429ccab
https://doi.org/10.1158/1535-7163.22502460
https://doi.org/10.1158/1535-7163.22502460
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 450KB, Biphasic distribution of the increase in binding affinity for conversion from monovalent to bivalent forms for antibodies with different intrinsic affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dad4b36218fddcc93214aa8599e29c9
https://doi.org/10.1158/1535-7163.22498900.v1
https://doi.org/10.1158/1535-7163.22498900.v1
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 95KB, Comparison of cell-binding curves for low and high affinity anti-EGFR IgG antibodies at the experimental incubation time and a hypothetical time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d912714f35509e5cb38fad73680d2e5
https://doi.org/10.1158/1535-7163.22498897
https://doi.org/10.1158/1535-7163.22498897
Autor:
Michael G. Rosenblum, Gregory P. Adams, Chun Li, Kim Boland, Lawrence H. Cheung, John W. Marks, Xiaoxia Wen, Walter N. Hittelman, Chiyi Xiong, Stephen I. Rudnick, Qian Huang, James D. Marks, Yu Cao
PDF file - 1215KB, Enzymatic activities of AST and LDH in the serum of mice with or without tumors, treated with rGel, MH3-B1/rGel or B1D3/rGel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa6eb57746e83a9d2821898ca3fa9e1
https://doi.org/10.1158/1535-7163.22498732
https://doi.org/10.1158/1535-7163.22498732
Autor:
Michael G. Rosenblum, Gregory P. Adams, Chun Li, Kim Boland, Lawrence H. Cheung, John W. Marks, Xiaoxia Wen, Walter N. Hittelman, Chiyi Xiong, Stephen I. Rudnick, Qian Huang, James D. Marks, Yu Cao
PDF file - 1877KB, Statistical comparisons of Tissue-to-Muscle Ratio (tumor or liver to muscle ratio) of IRDye800-MH3-B1/rGel and IRDye800-B1D3/rGel after 24h (A) and 72h (B) injection to BT474 M1 xenograft tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa2ae15289b7e5f5eb22fd068fa49be
https://doi.org/10.1158/1535-7163.22498735.v1
https://doi.org/10.1158/1535-7163.22498735.v1