Zobrazeno 1 - 10
of 62
pro vyhledávání: '"James D Vasta"'
Autor:
Johannes Dopfer, James D. Vasta, Susanne Müller, Stefan Knapp, Matthew B. Robers, Martin P. Schwalm
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Abstract Investigating ligand-protein complexes is essential in the areas of chemical biology and drug discovery. However, detailed information on key reagents such as fluorescent tracers and associated data for the development of widely used biolumi
Externí odkaz:
https://doaj.org/article/ee95d31948214e78a2c11232b7e4484c
Autor:
Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon Heller, Annika Böhme, Ralf Lesche, Oliver vonAhsen, Sylvia Grünewald, Holly M. Nguyen, Eva Corey, Simon J. Baumgart, Victoria Georgi, Vera Pütter, Amaury Fernández‐Montalván, James D. Vasta, Matthew B. Robers, Oliver Politz, Dominik Mumberg, Bernard Haendler
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 726-742 (2024)
Prostate cancer is a frequent malignancy in older men and has a very high 5‐year survival rate if diagnosed early. The prognosis is much less promising if the tumor has already spread outside the prostate gland. Targeted treatments mainly aim at bl
Externí odkaz:
https://doaj.org/article/d4cfe16cad13404788f8437fa5048036
Autor:
Jacob L. Capener, James D. Vasta, Vittorio L. Katis, Ani Michaud, Michael T. Beck, Sabrina C. D. Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B. Robers, Alison D. Axtman, Frances M. Bashore
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that is activated by phosphorylation events downstream of FcR, B-cell and T-cell receptors, integrins, and C-type lectin receptors. When the tandem Src homology 2 (SH2) domains of SYK bin
Externí odkaz:
https://doaj.org/article/5b14e25fb79449cd9a67529c673d86a8
Autor:
Xuan Yang, Jeffery L. Smith, Michael T. Beck, Jennifer M. Wilkinson, Ani Michaud, James D. Vasta, Matthew B. Robers, Timothy M. Willson
Publikováno v:
Molecules, Vol 28, Iss 7, p 2950 (2023)
PLK1 is a protein kinase that regulates mitosis and is both an important oncology drug target and a potential antitarget of drugs for the DNA damage response pathway or anti-infective host kinases. To expand the range of live cell NanoBRET target eng
Externí odkaz:
https://doaj.org/article/d38f4c63c4d142138e67e669810bc196
Autor:
Martin P. Schwalm, Lena M. Berger, Maximilian N. Meuter, James D. Vasta, Cesear R. Corona, Sandra Röhm, Benedict-Tilman Berger, Frederic Farges, Sebastian M. Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V. Rogov, Sebastian Mathea, Krishna Saxena, Matthew B. Robers, Susanne Müller, Stefan Knapp
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
E3 ligases constitute a large and diverse family of proteins that play a central role in regulating protein homeostasis by recruiting substrate proteins via recruitment domains to the proteasomal degradation machinery. Small molecules can either inhi
Externí odkaz:
https://doaj.org/article/bc038599fbfd4e358a76cbc206775e95
Autor:
Carrow I. Wells, James D. Vasta, Cesear R. Corona, Jennifer Wilkinson, Chad A. Zimprich, Morgan R. Ingold, Julie E. Pickett, David H. Drewry, Kathryn M. Pugh, Marie K. Schwinn, Byounghoon (Brian) Hwang, Hicham Zegzouti, Kilian V. M. Huber, Mei Cong, Poncho L. Meisenheimer, Timothy M. Willson, Matthew B. Robers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probe
Externí odkaz:
https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf
Autor:
Matthew B. Robers, Jennifer M. Wilkinson, James D. Vasta, Lena M. Berger, Benedict-Tilman Berger, Stefan Knapp
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100822- (2021)
Summary: This protocol is used to profile the engagement of kinase inhibitors across nearly 200 kinases in a live-cell context. This protocol utilizes one single kinase tracer (NanoBRET(TM) Tracer K10) that operates quantitatively at four different c
Externí odkaz:
https://doaj.org/article/751fa5ff2d3441ebaf399265a1e71e7a
Autor:
Nathan H. Murray, Christopher R. M. Asquith, Zixiang Fang, Michael P. East, Naomi Ptak, Robert W. Smith, James D. Vasta, Chad A. Zimprich, Cesear R. Corona, Matthew B. Robers, Gary L. Johnson, Craig A. Bingman, David J. Pagliarini
Publikováno v:
Nature Chemical Biology. 19:230-238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08957fe09a54ad6d22eecb0abe8228d9
https://doi.org/10.1038/s41589-022-01168-3
https://doi.org/10.1038/s41589-022-01168-3
Autor:
Michael J. Eck, Stefan Laufer, Bo Hee Shin, Stefan Knapp, Pasi A. Jänne, David E. Heppner, Anna M Schmoker, Matthew B. Robers, Tyler S. Beyett, James D Vasta, Ciric To, Nicolas Bauer, Jaimin K. Rana, Cesear Corona, Marcel Günther, Lena M. Berger, Florian Wittlinger, Benedict-Tilman Berger
Publikováno v:
Journal of Medicinal Chemistry. 65:1370-1383
Inhibitors targeting the epidermal growth factor receptor (EGFR) are an effective therapy for patients with non-small cell lung cancer harboring drug-sensitive activating mutations in the EGFR kinase domain. Drug resistance due to treatment-acquired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60cdfff3107b6d5a3ce0d8c8e48c4550
https://doi.org/10.1021/acs.jmedchem.1c00848
https://doi.org/10.1021/acs.jmedchem.1c00848
Autor:
Matthew B. Robers, Thomas Machleidt, Marie K. Schwinn, Danette L. Daniels, Kristin M. Riching, Marjeta Urh, James D Vasta
Publikováno v:
SLAS Discovery. 26:560-569
Targeted protein degradation using heterobifunctional proteolysis-targeting chimera (PROTAC) compounds, which recruit E3 ligase machinery to a target protein, is increasingly becoming an attractive pharmacologic strategy. PROTAC compounds are often d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac37e04d943fab77cf8cf94da1f3e11
https://doi.org/10.1177/2472555220973602
https://doi.org/10.1177/2472555220973602