Zobrazeno 1 - 10
of 311
pro vyhledávání: '"James D Marks"'
Autor:
Yongfeng Fan, Zhengda Sun, Fraser Conrad, Weihua Wen, Lequn Zhao, Jianlong Lou, Yu Zhou, Shauna Farr-Jones, James D Marks
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273512 (2022)
Generating specific monoclonal antibodies (mAbs) that neutralize multiple antigen variants is challenging. Here, we present a strategy to generate mAbs that bind seven subtypes of botulinum neurotoxin serotype F (BoNT/F) that differ from each other i
Externí odkaz:
https://doaj.org/article/7144f5bc7dae452e9022a675df09d5ef
Autor:
Yongfeng Fan, Consuelo Garcia-Rodriguez, Jianlong Lou, Weihua Wen, Fraser Conrad, Wenwu Zhai, Theresa J Smith, Leonard A Smith, James D Marks
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174187 (2017)
Human botulism is primarily caused by botulinum neurotoxin (BoNT) serotypes A, B and E, with around 1% caused by serotype F (BoNT/F). BoNT/F comprises at least seven different subtypes with the amino acid sequence difference between subtypes as high
Externí odkaz:
https://doaj.org/article/6184a309773e437897fdc911de7196ba
Autor:
Yongfeng Fan, Isin N Geren, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Theresa J Smith, Leonard A Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A Wilson, James D Marks
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135306 (2015)
The paralytic disease botulism is caused by botulinum neurotoxins (BoNT), multi-domain proteins containing a zinc endopeptidase that cleaves the cognate SNARE protein, thereby blocking acetylcholine neurotransmitter release. Antitoxins currently used
Externí odkaz:
https://doaj.org/article/9b7eb01863404d988154a05871b0cbf5
Autor:
Jimson W D'Souza, Smitha Reddy, Lisa E Goldsmith, Irina Shchaveleva, James D Marks, Samuel Litwin, Matthew K Robinson
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112376 (2014)
Inappropriate signaling through the epidermal growth factor receptor family (EGFR1/ERBB1, ERBB2/HER2, ERBB3/HER3, and ERBB4/HER4) of receptor tyrosine kinases leads to unregulated activation of multiple downstream signaling pathways that are linked t
Externí odkaz:
https://doaj.org/article/de2f6ddec96a48f9bca90652df0b0d87
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111339 (2014)
Antibodies are ubiquitous and essential reagents for biomedical research. Uses of antibodies include quantifying proteins, identifying the temporal and spatial pattern of expression in cells and tissue, and determining how proteins function under nor
Externí odkaz:
https://doaj.org/article/4d59025cc89449c9ba9ca03338eeb381
Autor:
Suzanne R Kalb, Consuelo Garcia-Rodriguez, Jianlong Lou, Jakub Baudys, Theresa J Smith, James D Marks, Leonard A Smith, James L Pirkle, John R Barr
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12237 (2010)
Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing respiratory failure leading to long-term intensive care or death. The best treatment for botulism includes serotype-specific antitoxins, which are most effective wh
Externí odkaz:
https://doaj.org/article/9caf32e0dd4847e3b0283cc991a9e87a
Autor:
Suzanne R Kalb, Jianlong Lou, Consuelo Garcia-Rodriguez, Isin N Geren, Theresa J Smith, Hercules Moura, James D Marks, Leonard A Smith, James L Pirkle, John R Barr
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5355 (2009)
Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing death or respiratory failure leading to long-term intensive care. Treatment includes serotype-specific antitoxins, which must be administered early in the course of
Externí odkaz:
https://doaj.org/article/d9de18d06e124a92a755cd820f3789e2
Autor:
Theresa J Smith, Karen K Hill, Brian T Foley, John C Detter, A Christine Munk, David C Bruce, Norman A Doggett, Leonard A Smith, James D Marks, Gary Xie, Thomas S Brettin
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1271 (2007)
BackgroundClostridium botulinum and related clostridial species express extremely potent neurotoxins known as botulinum neurotoxins (BoNTs) that cause long-lasting, potentially fatal intoxications in humans and other mammals. The amino acid variation
Externí odkaz:
https://doaj.org/article/26ac0c1186014ed1bdf64f29a1083e3d
Autor:
Alexandra B. Steverson, MD, MPH, Paul J. Marano, MD, Caren Chen, MPH, Yifei Ma, MS, Rachel J. Stern, MD, Jean Feng, MS, PhD, Efstathios D. Gennatas, MBBS, PhD, James D. Marks, MD, PhD, Matthew S. Durstenfeld, MD, MAS, Jonathan D. Davis, MD, MPHS, Priscilla Y. Hsue, MD, Lucas S. Zier, MD, MS
Publikováno v:
American Journal of Medicine Open, Vol 10, Iss , Pp 100060- (2023)
Introduction: Heart failure (HF) is a frequent cause of readmissions. Despite caring for underresourced patients and dependence on government funding, safety net hospitals frequently incur penalties for failing to meet pay-for-performance readmission
Externí odkaz:
https://doaj.org/article/8412fd4464a642a7b3a37c3dc292fd91
Autor:
Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Publikováno v:
Toxins, Vol 15, Iss 5, p 316 (2023)
Equine-derived antitoxin (BAT®) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT® is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable
Externí odkaz:
https://doaj.org/article/276c0b76216c46e0a1b5bb0297a8d1eb