Zobrazeno 1 - 10
of 71
pro vyhledávání: '"James D Lord"'
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0285918 (2023)
ObjectivesMucosal-Associated Invariant T (MAIT) cells are T cells with a semi-invariant T cell receptor (TCR), recognizing riboflavin precursors presented by a non-polymorphic MR1 molecule. As these precursors are produced by the gut microbiome, we c
Externí odkaz:
https://doaj.org/article/a8d7982345744f61a52d4f080210c251
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136485 (2015)
FOXP3+ regulatory T cells (Tregs) are critical for preventing intestinal inflammation. However, FOXP3+ T cells are paradoxically increased in the intestines of patients with the inflammatory bowel disease (IBD) ulcerative colitis (UC) or Crohn's dise
Externí odkaz:
https://doaj.org/article/e66bfb1dc99c424fbf68107b0700c84b
Autor:
Amiko M. Uchida, Elisa K. Boden, Eddie A. James, Donna M. Shows, Andrew J. Konecny, James D. Lord
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 507-526 (2020)
Background & Aims: Crohn’s disease (CD) likely represents decreased immune tolerance to intestinal bacterial antigens. Most CD patients have high titers of antibodies to intestinal commensal proteins, including the outer membrane porin C (OmpC) of
Externí odkaz:
https://doaj.org/article/98759850dda64024b22ff773edf37060
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
FOXP3+regulatory T cells (Treg) depend on exogenous IL-2 for their survival and function, but circulating levels of IL-2 are low, making it unclear how Treg access this critical resourcein vivo. Here, we show that Treg use heparanase (HPSE) to access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3a27b1b35c15b8513b6ec998e27215
https://doi.org/10.1101/2023.02.26.529772
https://doi.org/10.1101/2023.02.26.529772
Autor:
Michael C. Larsen, Andrew S. Ross, Elisa K. Boden, Michael Chiorean, Richard A. Kozarek, Shayan Irani, James D. Lord, Hyun Seok Lee
Publikováno v:
Digestive Diseases and Sciences. 67:1295-1302
Fluoroscopy is often used for endoscopic balloon dilation (EBD) of Crohn’s disease (CD)-related strictures. However, its benefit remains unclear. To compare EBD with (EBDF) and without (EBDNF) fluoroscopic guidance in CD patients with strictures. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886724fba2b6ef3d75a1acaf30bf1438
https://doi.org/10.1007/s10620-021-06935-1
https://doi.org/10.1007/s10620-021-06935-1
Publikováno v:
ImmunoHorizons. 6(3)
Successful treatment of inflammatory bowel disease (IBD) with the anti-integrin α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8fee797b3f558cfc73d8ba62b9d4627
https://pubmed.ncbi.nlm.nih.gov/35273097
https://pubmed.ncbi.nlm.nih.gov/35273097
Autor:
Karthik Mouli, Elena Kamynina, Seth A. Peng, Becca A. Flitter, Bridget M. Mooney, Pamela Campioli, Rebecca L. Cubitt, Michael J. Shanahan, Isabella Rauch, Simon P. Früh, Oyebola O. Oyesola, James D. Lord, Marija S. Nadjsombati, Praveen Sethupathy, Madeline J Churchill, Jakob von Moltke, Shuchi Smita, Karsten Gronert, Macy K. Matheson, Duc H. Pham, Matt Kanke, Jordan L. Cahoon, Elia D. Tait Wojno, Pavithra Sundaravaradan, John W. McGinty, Lauren M. Webb
Publikováno v:
The Journal of Experimental Medicine
Type 2 cytokines promote epithelial changes that help to expel worms during intestinal helminth infection. Oyesola et al. show that prostaglandin D2 and its receptor CRTH2 are novel negative regulators of this response, dampening the Type 2 cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634e6869920806c0d6f27c6239769b1e
http://europepmc.org/articles/PMC8294949
http://europepmc.org/articles/PMC8294949
Publikováno v:
The Journal of Immunology. 208:48.14-48.14
Vedolizumab blocks integrin alpha4/beta7 interaction with MAdCAM-1 on intestinal vascular endothelial cells. It is believed to treat inflammatory bowel disease (IBD) by preventing alpha4/beta7+ cells in blood from entering the intestinal mucosa. By C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12e528f231bad9b2ee44ca5af4567f94
https://doi.org/10.4049/jimmunol.208.supp.48.14
https://doi.org/10.4049/jimmunol.208.supp.48.14
Publikováno v:
Gastroenterology. 162:S-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e913b82c6d3cc13fbbaaf0dfe36764
https://doi.org/10.1016/s0016-5085(22)60124-0
https://doi.org/10.1016/s0016-5085(22)60124-0
Autor:
James D. Lord, Mara Monetti, Flora Martz, Ramya Kongala, Caitlyn Dickinson, Jeffrey A. Culver, Isac Lee, Scott Jelinsky, Marion Kasaian
Publikováno v:
Gastroenterology. 162:S-517
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::909f7d60b436d77fb3d671e5bb06a60d
https://doi.org/10.1016/s0016-5085(22)61229-0
https://doi.org/10.1016/s0016-5085(22)61229-0