Zobrazeno 1 - 10
of 832
pro vyhledávání: '"James D Lewis"'
Autor:
Ben Boursi, Thomas J Werner, Saeid Gholami, Sina Houshmand, Ronac Mamtani, James D Lewis, Gary D Wu, Abass Alavi, Yu-Xiao Yang
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192747 (2018)
Recent data comparing germ-free to conventionally-raised mice demonstrated that energy homeostasis of colonocytes is dependent on gut microbiota through regulation of short chain fatty acids (SCFA) production and glucose utilization. We sought to eva
Externí odkaz:
https://doaj.org/article/e2e1939be45e41738783169edf5abc53
Autor:
James D. Lewis, Theresa Hunter Gibble, Mingyang Shan, Xian Zhou, April N. Naegeli, Ghadeer K. Dawwas
Publikováno v:
Drugs - Real World Outcomes, Vol 11, Iss 3, Pp 403-412 (2024)
Abstract Background Bowel urgency is a highly burdensome symptom among patients with inflammatory bowel disease (IBD). Objectives To assess changes in severity of bowel urgency and identify predictors of worsening or improvement among patients with C
Externí odkaz:
https://doaj.org/article/f17390a0c6ee45e5af7597538ea0fd14
Autor:
Ronac Mamtani, James D Lewis, Frank I Scott, Tariq Ahmad, David S Goldberg, Jashodeep Datta, Yu-Xiao Yang, Ben Boursi
Publikováno v:
PLoS Medicine, Vol 13, Iss 4, p e1002007 (2016)
BACKGROUND:Several prior studies have found an association between statin use and reduced risk of colorectal cancer. We hypothesized that these findings may be due to systematic bias and examined the independent association of colorectal cancer risk
Externí odkaz:
https://doaj.org/article/fe821a007cda4de79ef551c467725cf1
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105369 (2014)
The fitness effects of mutations are context specific and depend on both external (e.g., environment) and internal (e.g., cellular stress, genetic background) factors. The influence of population size and density on fitness effects are unknown, despi
Externí odkaz:
https://doaj.org/article/78910805685c46849814e8735973744b
Autor:
Serena Dollive, Ying-Yu Chen, Stephanie Grunberg, Kyle Bittinger, Christian Hoffmann, Lee Vandivier, Christopher Cuff, James D Lewis, Gary D Wu, Frederic D Bushman
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71806 (2013)
Antibiotic use in humans has been associated with outgrowth of fungi. Here we used a murine model to investigate the gut microbiome over 76 days of treatment with vancomycin, ampicillin, neomycin, and metronidazole and subsequent recovery. Mouse stoo
Externí odkaz:
https://doaj.org/article/0029825a2daf4359b6f86d837d4b4e3c
Autor:
Christian Hoffmann, Serena Dollive, Stephanie Grunberg, Jun Chen, Hongzhe Li, Gary D Wu, James D Lewis, Frederic D Bushman
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66019 (2013)
Diet influences health as a source of nutrients and toxins, and by shaping the composition of resident microbial populations. Previous studies have begun to map out associations between diet and the bacteria and viruses of the human gut microbiome. H
Externí odkaz:
https://doaj.org/article/3719c33d5d884352ba1d60e09f1d0503
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42342 (2012)
Viruses are a crucial component of the human microbiome, but large population sizes, high sequence diversity, and high frequencies of novel genes have hindered genomic analysis by high-throughput sequencing. Here we investigate approaches to metageno
Externí odkaz:
https://doaj.org/article/0d0b7a33cae24f949ad99b711d0e5a29
Autor:
Charlene W. Compher, Ryan Quinn, Frances Burke, Doris Piccinin, Linda Sartor, James D. Lewis, Gary D. Wu
Publikováno v:
Nutrition Journal, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background There is a need for a feasible, user-friendly tool that can be employed to assess the overall quality of the diet in U.S. clinical settings. Our objectives were to develop the Penn Healthy Diet (PHD) screener, evaluate screener it
Externí odkaz:
https://doaj.org/article/1d795e00a88b4f459ce42d30e509bb06
Autor:
Marla C. Dubinsky, Mingyang Shan, Laure Delbecque, Trevor Lissoos, Theresa Hunter, Gale Harding, Larissa Stassek, David Andrae, James D. Lewis
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 6, Iss 1, Pp 1-15 (2022)
Abstract Background The Urgency Numeric Rating Scale (NRS) was developed as a content-valid single-item patient-reported outcome measure to assess severity of bowel urgency. Here, we evaluated the psychometric properties of the Urgency NRS. Methods D
Externí odkaz:
https://doaj.org/article/c6a53c14aaa4456ebbad9e13ff396443
Autor:
Clara Delaroque, Gary D. Wu, Charlene Compher, Josephine Ni, Lindsey Albenberg, Qing Liu, Yuan Tian, Andrew D. Patterson, James D. Lewis, Andrew T. Gewirtz, Benoit Chassaing
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The human gut microbiota is highly heterogenous between individuals and also exhibits considerable day-to-day variation within individuals. We hypothesized that diet contributed to such inter- and/or intra-individual variance. Hence, we investigated
Externí odkaz:
https://doaj.org/article/c9150d8838324528b73a21e0fa9e215a