Zobrazeno 1 - 10
of 97
pro vyhledávání: '"James D, Winkler"'
Publikováno v:
Metabolic Engineering Communications, Vol 3, Iss , Pp 227-233 (2016)
We previously introduced the LASER database (Learning Assisted Strain EngineeRing, https://bitbucket.org/jdwinkler/laser_release) (Winkler et al. 2015) to serve as a platform for understanding past and present metabolic engineering practices. Over th
Externí odkaz:
https://doaj.org/article/f6ea9c6cc6d9470a80744e8ebc3596f4
Autor:
Jennifer R. Diamond, Todd M. Pitts, Dana Ungermannova, Christopher G. Nasveschuk, Gan Zhang, Andrew J. Phillips, Stacey M. Bagby, Jessica Pafford, Betelehem W. Yacob, Timothy P. Newton, John J. Tentler, Brian Gittleman, Sarah J. Hartman, John A. DeMattei, James D. Winkler, Michael K. Wendt, William P. Schiemann, S. Gail Eckhardt, Xuedong Liu, Anthony D. Piscopio
Publikováno v:
Mol Cancer Ther
Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. Although HDAC inhibitors are active in T-cell lymphomas, poor isoform selectivity, narrow therapeutic indices, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7f204038b194d4d2b23b9b7512f1bf
https://doi.org/10.1158/1535-7163.mct-21-0455
https://doi.org/10.1158/1535-7163.mct-21-0455
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Supplementary Data from Preclinical Development of the Class-I–Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66cc0ba3e4bb3154d809f1ce9e18868
https://doi.org/10.1158/1535-7163.22522086
https://doi.org/10.1158/1535-7163.22522086
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. Although HDAC inhibitors are active in T-cell lymphomas, poor isoform selectivity, narrow therapeutic indices, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca10d3d7a768f89abeba39b0600ff66
https://doi.org/10.1158/1535-7163.c.6543273
https://doi.org/10.1158/1535-7163.c.6543273
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Supplementary Figure from Preclinical Development of the Class-I–Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21396584792a719c719476ad7fe8d703
https://doi.org/10.1158/1535-7163.22522083
https://doi.org/10.1158/1535-7163.22522083
Autor:
Eli Wallace, Kevin Koch, James D. Winkler, Patrice A. Lee, Joe Lyssikatos, Brian Hurley, Allison Marlow, Stefan Gross, Barbara J. Brandhuber, Darin Smith, Janet Parry, Ron J. Evans, Heidi Colwell, Josh Ballard, Bryan A. Bernat, Vivienne Marsh, Tammie C. Yeh
Supplementary Data, Yeh, et al. from Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb220f9585897004967629e2407f636
https://doi.org/10.1158/1078-0432.22441213.v1
https://doi.org/10.1158/1078-0432.22441213.v1
Autor:
Eli Wallace, Kevin Koch, James D. Winkler, Patrice A. Lee, Joe Lyssikatos, Brian Hurley, Allison Marlow, Stefan Gross, Barbara J. Brandhuber, Darin Smith, Janet Parry, Ron J. Evans, Heidi Colwell, Josh Ballard, Bryan A. Bernat, Vivienne Marsh, Tammie C. Yeh
Purpose: The Ras-Raf-mitogen-activated protein kinase kinase (MEK) pathway is overactive in many human cancers and is thus a target for novel therapeutics. We have developed a highly potent and selective inhibitor of MEK1/2. The purpose of these stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406a4a31b0cf89e0543cd3f66dfd4a9e
https://doi.org/10.1158/1078-0432.c.6518341.v1
https://doi.org/10.1158/1078-0432.c.6518341.v1
Publikováno v:
Metabolic Engineering Communications, Vol 2, Iss , Pp 30-38 (2015)
The ability of metabolic engineers to conceptualize, implement, and evaluate strain designs has dramatically increased in the last decade. Unlike other engineering fields, no centralized, open-access, and easily searched repository exists for catalog
Externí odkaz:
https://doaj.org/article/9a31ee6f051c4d94a09b58349bb09076
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT The standard genetic code is robust to mutations during transcription and translation. Point mutations are likely to be synonymous or to preserve the chemical properties of the original amino acid. Saturation mutagenesis experiments suggest
Externí odkaz:
https://doaj.org/article/2254fccf94434b5795fa8d1833abadee
Autor:
S. Lindsey Davis, Gilad Gordon, S. Gail Eckhardt, Jose M. Pacheco, Anthony D. Piscopio, James D. Winkler, Amy M. Heim, Christopher H. Lieu, Bradley R. Corr, Jennifer R. Diamond, Todd A. Triplett, Sunnie S. Kim, Jodi A. Kagihara, John A. DeMattei, Antonio Jimeno
Publikováno v:
Journal of Clinical Oncology. 39:3075-3075
3075 Background: OKI-179 is a novel, oral pro-drug analog of largazole, a compound in the romidepsin-depsipeptide class of natural products. OKI-006, the active metabolite of OKI-179, inhibits HDAC 1,2,3 (IC50 = 1.2, 2.4, 2.0 nM, respectively), with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ff5ca2c2b6ab8b5b38187b2bb4b1cd5
https://doi.org/10.1200/jco.2021.39.15_suppl.3075
https://doi.org/10.1200/jco.2021.39.15_suppl.3075