Zobrazeno 1 - 10
of 24
pro vyhledávání: '"James D, Sunderhaus"'
Autor:
Jacob N. Sanders, Ying Ye, Timothy J. McAfoos, Fengan Yu, Amy E. Fraley, Sean A. Newmister, W. Clay Brown, Qingyun Dan, James D. Sunderhaus, Robert S. Paton, Vikram V. Shende, Amber D. Somoza, David H. Sherman, Kendall N. Houk, Kimberly R. Klas, Robert M. Williams, Janet L. Smith, Le Zhao
Publikováno v:
Nature chemistry, vol 11, iss 11
Nat Chem
Nat Chem
Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, we report complete elucidation of the malbrancheamide biosynthetic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5776cdefa3e7b958004a150ba9a2a26
https://doi.org/10.26434/chemrxiv.7505486
https://doi.org/10.26434/chemrxiv.7505486
Autor:
Amber D. Somoza, Timothy J. McAfoos, Amy E. Fraley, W. Clay Brown, Ying Ye, Vikram V. Shende, Kendall N. Houk, James D. Sunderhaus, Robert S. Paton, David H. Sherman, Le Zhao, Fengan Yu, Sean A. Newmister, Janet L. Smith, Kimberly R. Klas, Qingyun Dan, Robert M. Williams, Jacob N. Sanders
Prenylated indole alkaloids isolated from various fungi possess great structural diversity and pharmaceutical utility. Among them are the calmodulin inhibitory malbrancheamides and paraherquamides, used as anthelmintics in animal health. Herein, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::465d004ca4467d72afeaee754cc5c22b
https://doi.org/10.26434/chemrxiv.7505486.v1
https://doi.org/10.26434/chemrxiv.7505486.v1
Autor:
Robert M. Williams, Aika Kai, Jennifer M. Finefield, Tetsuro Kawabata, Sachiko Tsukamoto, Yukihiko Sugimoto, James D. Sunderhaus, Hikaru Kato, Timothy J. McAfoos
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(14)
The marine-derived Aspergillus protuberus MF297-2 and the terrestrial A. amoenus NRRL 35600 produce enantiomeric prenylated indole alkaloids. Investigation of biological activities of the natural and synthetic derivatives revealed that (−)-enantiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf227ce0c0d52677feca41bc321793d
https://pubmed.ncbi.nlm.nih.gov/29037945
https://pubmed.ncbi.nlm.nih.gov/29037945
Autor:
Jennifer M. Finefield, James D. Sunderhaus, David H. Sherman, Hikaru Kato, Robert M. Williams, Takashi Nakahara, Sachiko Tsukamoto, Ippei Kagiyama, Michitaka Yamaguchi
Publikováno v:
Tetrahedron Letters. 56(1):247-251
We previously described the bioconversion of Notoamide T into (+)-Stephacidin A and (−)-Notoamide B, which suggested that Versicolamide B (8) is biosynthesized from 6-epi-Notoamide T (10) via 6-epi-Stephacidin A. Here we report that [13C]2-10 was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46045ac5eac607aad59ff0d365cce764
http://hdl.handle.net/2298/00043552
http://hdl.handle.net/2298/00043552
Autor:
Timothy J. McAfoos, Robert M. Williams, Jennifer M. Finefield, David H. Sherman, Hikaru Kato, Sachiko Tsukamoto, Shengying Li, James D. Sunderhaus
Publikováno v:
Organic Letters. 15:22-25
In an effort to further elucidate the biogenesis of the stephacidin and notoamide families of natural products, notoamide T has been identified as the likely precursor to stephacidin A. The total synthesis of notoamide T is described along with it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c52aad00c35c37a4a923f3256ecae3f
https://doi.org/10.1021/ol302901p
https://doi.org/10.1021/ol302901p
Autor:
Shengying Li, Jennifer M. Finefield, David H. Sherman, Robert M. Williams, James D. Sunderhaus, Timothy J. McAfoos
Publikováno v:
Journal of the American Chemical Society. 134:788-791
Notoamides produced by Aspergillus spp. bearing the bicyclo[2.2.2]diazaoctane core structure with unusual structural diversity represent a compelling system to understand the biosynthesis of fungal prenylated indole alkaloids. Herein, we report the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3565c66a2da801666d10e341286c4b5
https://doi.org/10.1021/ja2093212
https://doi.org/10.1021/ja2093212
Publikováno v:
Israel Journal of Chemistry. 51:442-452
The stephacidin and notoamide natural products belong to a group of prenylated indole alkaloids containing a bicyclo[2.2.2]diazaoctane core. Biosynthetically, this bicyclic core is believed to be the product of an intermolecular Diels- Alder (IMDA) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac0a3c15e7c7f95b5631470b158173d
https://doi.org/10.1002/ijch.201100016
https://doi.org/10.1002/ijch.201100016
Publikováno v:
Organic Letters. 12:3622-3625
A concise synthesis of (+/-)-pseudotabersonine from commercially available 1-(phenylsulfonyl)-3-indolecarboxaldehyde has been accomplished. This synthesis features the convergent assembly of a key intermediate via a stepwise variant of a Mannich-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f82bfcfef978c7df6392854da6e2169
https://doi.org/10.1021/ol101356u
https://doi.org/10.1021/ol101356u
Publikováno v:
Tetrahedron. 65:6454-6469
A novel strategy has been developed for the efficient syntheses of diverse arrays of heterocyclic compounds. The key elements of the approach comprise a Mannich-type, multicomponent coupling reaction in which functionalized amines, aromatic aldehydes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8634606591d5dfeea6dc70ae244d24
https://doi.org/10.1016/j.tet.2009.05.009
https://doi.org/10.1016/j.tet.2009.05.009
A novel approach to the Aspidosperma family of alkaloids was developed and applied to a concise total synthesis of (±)-pseudotabersonine that was accomplished in 11 steps. Key transformations include a stepwise variant of a Mannich-like multicompone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce80ec3df1d8a1195319ee36e763fc28
https://europepmc.org/articles/PMC4542060/
https://europepmc.org/articles/PMC4542060/