Zobrazeno 1 - 10
of 449
pro vyhledávání: '"James D, Johnson"'
Autor:
Jia Zhao, Shenghui Liang, Haoning Howard Cen, Yanjun Li, Robert K. Baker, Balwinder Ruprai, Guang Gao, Chloe Zhang, Huixia Ren, Chao Tang, Liangyi Chen, Yanmei Liu, Francis C. Lynn, James D. Johnson, Timothy J. Kieffer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from current approaches, we devised a tunable strategy to generate islet spheroids enr
Externí odkaz:
https://doaj.org/article/1bdf64aed5f74d41bf7cbec2f67ff56c
Autor:
Cody Durrer, Hashim Islam, Haoning Howard Cen, Maria Dolores Moya Garzon, Xuchao Lyu, Sean McKelvey, Joel Singer, Alan M. Batterham, Jonathan Z. Long, James D. Johnson, Jonathan P. Little
Publikováno v:
Nutrition & Metabolism, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Background Substantial weight loss in people living with type 2 diabetes (T2D) can reduce the need for glucose-lowering medications while concurrently lowering glycemia below the diagnostic threshold for the disease. Furthermore, weight-loss
Externí odkaz:
https://doaj.org/article/93f13911ef7b4a3c8ed58a8449e3284a
Autor:
Tobias Boothe, Gareth E. Lim, Haoning Cen, Søs Skovsø, Micah Piske, Shu Nan Li, Ivan R. Nabi, Patrick Gilon, James D. Johnson
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101935- (2024)
Externí odkaz:
https://doaj.org/article/8d13a52234dc4c16ac9fc7f22cbbd870
Autor:
Marisol Castillo-Castrejon, Barbara Mensah Sankofi, Stevi Johnson Murguia, Abasi-ama Udeme, Hoaning Howard Cen, Yi Han Xia, Nisha S. Thomas, William L. Berry, Kenneth L. Jones, Vincent R. Richard, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson, Elizabeth A. Wellberg
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-21 (2023)
Abstract Background Obesity increases breast cancer risk and breast cancer-specific mortality, particularly for people with estrogen receptor (ER)-positive tumors. Body mass index (BMI) is used to define obesity, but it may not be the best predictor
Externí odkaz:
https://doaj.org/article/ddd8615423954129a10ae74ab8936c7b
Autor:
Paula T. Littlejohn, Haggai Bar-Yoseph, Karlie Edwards, Hong Li, Cynthia Y. Ramirez-Contreras, Ravi Holani, Avril Metcalfe-Roach, Yiyun M. Fan, Tom Min-Shih Yang, Nina Radisavljevic, Xiaoke Hu, James D. Johnson, B. Brett Finlay
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
IntroductionMicronutrients perform a wide range of physiological functions essential for growth and development. However, most people still need to meet the estimated average requirement worldwide. Globally, 2 billion people suffer from micronutrient
Externí odkaz:
https://doaj.org/article/b4ffca3968ed454d99e7b9e36376f9cd
Autor:
Tanner Stokes, Haoning Howard Cen, Philipp Kapranov, Iain J Gallagher, Andrew A. Pitsillides, Claude‐Henry Volmar, William E Kraus, James D. Johnson, Stuart M. Phillips, Claes Wahlestedt, James A. Timmons
Publikováno v:
Advanced Genetics, Vol 4, Iss 2, Pp n/a-n/a (2023)
Abstract Sequencing the human genome empowers translational medicine, facilitating transcriptome‐wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short‐rea
Externí odkaz:
https://doaj.org/article/e905fbd859144cbe92af1c8b24906620
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Anni M. Y. Zhang, Ken H. Chu, Brian F. Daly, Titine Ruiter, Yan Dou, Jenny C. C. Yang, Twan J. J. de Winter, Justin Chhuor, Su Wang, Stephane Flibotte, Yiwei Bernie Zhao, Xiaoke Hu, Hong Li, Elizabeth J. Rideout, David F. Schaeffer, James D. Johnson, Janel L. Kopp
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Background Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic intraepithelial neop
Externí odkaz:
https://doaj.org/article/ff9b541c39684bccacb601c1a9c7f635
Autor:
George P. Brownrigg, Yi Han Xia, Chieh Min Jamie Chu, Su Wang, Charlotte Chao, Jiashuo Aaron Zhang, Søs Skovsø, Evgeniy Panzhinskiy, Xiaoke Hu, James D. Johnson, Elizabeth J. Rideout
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101678- (2023)
Objective: Pancreatic β cells play a key role in maintaining glucose homeostasis; dysfunction of this critical cell type causes type 2 diabetes (T2D). Emerging evidence points to sex differences in β cells, but few studies have examined male-female
Externí odkaz:
https://doaj.org/article/374b1790b35f4f059d15bf42060d49ea
Autor:
Austin J. Taylor, Evgeniy Panzhinskiy, Paul C. Orban, Francis C. Lynn, David F. Schaeffer, James D. Johnson, Janel L. Kopp, C. Bruce Verchere
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101667- (2023)
Objectives: Pancreatic cancer risk is elevated approximately two-fold in type 1 and type 2 diabetes. Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression. IAPP has been reported to act as a
Externí odkaz:
https://doaj.org/article/3b960dd09db649a3b0d27836178a6bad