Zobrazeno 1 - 8
of 8
pro vyhledávání: '"James D, Finnigan"'
Autor:
Kristian Hollingsworth, Antonio Di Maio, Sarah-Jane Richards, Jean-Baptiste Vendeville, David E. Wheatley, Claire E. Council, Tessa Keenan, Hélène Ledru, Harriet Chidwick, Kun Huang, Fabio Parmeggiani, Andrea Marchesi, Wengang Chai, Ryan McBerney, Tomasz P. Kamiński, Matthew R. Balmforth, Alexandra Tamasanu, James D. Finnigan, Carl Young, Stuart L. Warriner, Michael E. Webb, Martin A. Fascione, Sabine Flitsch, M. Carmen Galan, Ten Feizi, Matthew I. Gibson, Yan Liu, W. Bruce Turnbull, Bruno Linclau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glycan-mediated interactions play a crucial role in biology and medicine, influencing signalling, immune responses, and disease pathogenesis. However, the use of glycans in biosensing and diagnostics is limited by cross-reactivity, as certai
Externí odkaz:
https://doaj.org/article/45fc41374e2f4ce2b12a1822076a1c13
Autor:
Henry Gould, William Cheung, James D. Finnigan, José Muñoz-Muñoz, Simon J. Charnock, Gary W. Black
Publikováno v:
Metabolites, Vol 13, Iss 9, p 1010 (2023)
Escherichia coli is an invaluable research tool for many fields of biology, in particular for the production of recombinant enzymes. However, the activity of many such recombinant enzymes cannot be determined using standard biochemical assays, as oft
Externí odkaz:
https://doaj.org/article/9100f8bd24d64e808d5ab900fc20a501
Autor:
Vanessa Harawa, Thomas W. Thorpe, James R. Marshall, Jack J. Sangster, Amelia K. Gilio, Lucian Pirvu, Rachel S. Heath, Antonio Angelastro, James D. Finnigan, Simon J. Charnock, Jordan W. Nafie, Gideon Grogan, Roger C. Whitehead, Nicholas J. Turner
Publikováno v:
Journal of the American Chemical Society. 144:21088-21095
The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due to their prevalence in medicinally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23aa7ab7b31cb6dbf8ecf0b40391805
https://doi.org/10.1021/jacs.2c07143
https://doi.org/10.1021/jacs.2c07143
Publikováno v:
Organic Process Research & Development. 26:2096-2101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67ffe612bd3c5faf82b318615b10413
https://doi.org/10.1021/acs.oprd.2c00017
https://doi.org/10.1021/acs.oprd.2c00017
Autor:
Fei Zhao, Kate Lauder, Siyu Liu, James D. Finnigan, Simon B. R. Charnock, Simon J. Charnock, Daniele Castagnolo
Publikováno v:
Angewandte Chemie (International ed. in English). 61(31)
Chiral β-hydroxysulfides are an important class of organic compounds which find broad application in organic and pharmaceutical chemistry. Herein we describe the development of novel biocatalytic and chemoenzymatic methods for the enantioselective s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa4b5cc3e363c09c9b770f3c66de840
https://pubmed.ncbi.nlm.nih.gov/35576553
https://pubmed.ncbi.nlm.nih.gov/35576553
Autor:
Thomas W. Thorpe, James R. Marshall, Vanessa Harawa, Rebecca E. Ruscoe, Anibal Cuetos, James D. Finnigan, Antonio Angelastro, Rachel S. Heath, Fabio Parmeggiani, Simon J. Charnock, Roger M. Howard, Rajesh Kumar, David S. B. Daniels, Gideon Grogan, Nicholas J. Turner
Publikováno v:
Nature. 604(7904)
Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355d3c99d9ee3ccdaa5c64ef66aa41af
https://pubmed.ncbi.nlm.nih.gov/35388195
https://pubmed.ncbi.nlm.nih.gov/35388195
Publikováno v:
Advances in protein chemistry and structural biology. 122
Cytochromes P450 (P450s) are a large superfamily of heme-containing monooxygenases. P450s are found in all Kingdoms of life and exhibit incredible diversity, both at sequence level and also on a biochemical basis. In the majority of cases, P450s can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30b2d65304f9f32b5c944b1eb6d9b4e7
https://pubmed.ncbi.nlm.nih.gov/32951814
https://pubmed.ncbi.nlm.nih.gov/32951814
Autor:
Ashleigh J. Burke, William R. Birmingham, Ying Zhuo, Thomas W. Thorpe, Bruna Zucoloto da Costa, Rebecca Crawshaw, Ian Rowles, James D. Finnigan, Carl Young, Gregory M. Holgate, Mark P. Muldowney, Simon J. Charnock, Sarah L. Lovelock, Nicholas J. Turner, Anthony P. Green
Publikováno v:
Journal of the American Chemical Society. 144(9):3761-3765
The Covid-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue recently approved as an orally availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a537d5fb97b19c9e7a23e3bf6121ad