Zobrazeno 1 - 10
of 78
pro vyhledávání: '"James D, Anholm"'
Autor:
Prajan Subedi, Christopher Gasho, Michael Stembridge, Alexandra M. Williams, Alexander Patrician, Philip N. Ainslie, James D. Anholm
Publikováno v:
Experimental Physiology, Vol 108, Iss 1, Pp 111-122 (2023)
Abstract Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were lo
Externí odkaz:
https://doaj.org/article/14c45d9702594740a9d007e981f1c48d
Autor:
Hengji Chen, Sangeeta Joshi, Amber J. Oberle, An-Kwok Wong, David Shaz, Suman Thapamagar, Laren Tan, James D. Anholm, Paresh C. Giri, Craig Henriquez, Yuh-Chin T. Huang
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Excessive decrease in the flow of the late expiratory portion of a flow volume loop (FVL) or “flattening”, reflects small airway dysfunction. The assessment of the flattening is currently determined by visual inspection by the pulmonary function
Externí odkaz:
https://doaj.org/article/3813fa5367294690a79df5366dd597f8
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248466 (2021)
IntroductionChronic obstructive pulmonary disease (COPD) patients have poor sleep quality, longer time to sleep onset and frequent nocturnal awakenings. Poor sleep quality in COPD is associated with poor quality of life (QoL), increased exacerbations
Externí odkaz:
https://doaj.org/article/da1263e0f5c443679e79a2321787eee8
Autor:
Gustavo Vizcardo-Galindo, Ryan L. Hoiland, Christopher Gasho, Francisco C. Villafuerte, Kaitlyn Tymko, Courtney Tymko, James D. Anholm, John D. Akins, Philip N. Ainslie, Michael M. Tymko, Travis D. Gibbons, Rachel Stone, Geoff B. Coombs, Mike Stembridge, Connor A. Howe, Damian M. Bailey, Joshua C. Tremblay, Tony G. Dawkins, Alexander Patrician, Benjamin S. Stacey, Rómulo Figueroa-Mujíca
Publikováno v:
Chest. 161:1022-1035
BACKGROUND: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andeans with chronic mountain sickness (CMS) is resistant to iron adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b782c7ad08d714e67219d696a015ac2c
https://doi.org/10.1016/j.chest.2021.08.075
https://doi.org/10.1016/j.chest.2021.08.075
Autor:
Michael M. Tymko, Christopher K. Willie, Connor A. Howe, Ryan L. Hoiland, Rachel M. Stone, Kaitlyn Tymko, Courtney Tymko, David MacLeod, James D. Anholm, Christopher Gasho, Francisco Villafuerte, Gustavo Vizcardo-Galindo, Romulo Figueroa-Mujica, Trevor A. Day, Jordan D. Bird, Glen E. Foster, Craig D. Steinback, Julien V. Brugniaux, Benoit Champigneulle, Emeric Stauffer, Stephane Doutreleau, Samuel Verges, Erik R. Swenson, Philip N. Ainslie
Publikováno v:
Journal of Applied Physiology
Journal of Applied Physiology, 2022, 132 (2), pp.575-580. ⟨10.1152/japplphysiol.00757.2021⟩
Journal of Applied Physiology, 2022, 132 (2), pp.575-580. ⟨10.1152/japplphysiol.00757.2021⟩
International audience; High-altitude exposure results in a hyperventilatory-induced respiratory alkalosis followed by renal compensation (bicarbonaturia) to return arterial blood pH (pHa) toward sea-level values. However, acid-base balance has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a06759ec21ddc2a913ae0344d8acadd
https://doi.org/10.1152/japplphysiol.00757.2021
https://doi.org/10.1152/japplphysiol.00757.2021
Autor:
Carl Foster, James D. Anholm, Daniel Bok, Daniel Boullosa, Giancarlo Condello, Cristina Cortis, Andrea Fusco, Salvador J. Jaime, Jos J. de Koning, Alejandro Lucia, John P. Porcari, Kim Radtke, Jose A. Rodriguez-Marroyo
Publikováno v:
Journal of Functional Morphology and Kinesiology, Vol 5, Iss 3, Pp 63-0 (2020)
Although there is evidence supporting the benefit of regular exercise, and recommendations about exercise and physical activity, the process of individually prescribing exercise following exercise testing is more difficult. Guidelines like % heart ra
Externí odkaz:
https://doaj.org/article/3924519e2a3840b79ed69dcdebacc6c1
Autor:
Justin S. Lawley, Christopher M. Hearon, Sachin B. Amin, Steven A. Romero, Christopher Gasho, Philip N. Ainslie, Mike Stembridge, Francisco C. Villafuerte, Alexander B. Hansen, Michael M. Tymko, Tony G. Dawkins, Florian Hofstaetter, James D. Anholm, Gilbert Moralez, Lydia L. Simspon
Publikováno v:
The Journal of Physiology. 599:4021-4044
Key points Humans suffering from polycythaemia undergo multiple circulatory adaptations including changes in blood rheology and structural and functional vascular adaptations to maintain normal blood pressure and vascular shear stresses, despite high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8076dd903d23248a0025b022c0fbc8fd
https://doi.org/10.1113/jp281730
https://doi.org/10.1113/jp281730
Autor:
David B. MacLeod, Giovanfrancesco Varoli, Alexandra M. Williams, Christopher Gasho, Philip N. Ainslie, Mike Stembridge, Daniela Nowak-Flück, Alexander Patrician, Lindsay K. Eller, Michael M. Tymko, Gordon Binsted, Prajan Subedi, Ryan L. Hoiland, Emily McBride, Raylene A. Reimer, Christopher K. Willie, Sawyer Plato, James D. Anholm, Aimee L. Drane
Publikováno v:
The Journal of Physiology. 599:1685-1708
Key points Iron acts as a cofactor in the stabilization of the hypoxic-inducible factor family, and likely plays an influential role in the modulation of hypoxic pulmonary vasoconstriction. It is uncertain whether iron regulation is altered in lowlan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b948a46534be9803eae01f9d2d43ffc3
https://doi.org/10.1113/jp281114
https://doi.org/10.1113/jp281114
Autor:
Craig D. Steinback, James D. Anholm, Francisco C. Villafuerte, Travis D. Gibbons, Ryan L. Hoiland, Geoff B. Coombs, Connor A. Howe, Alexander Patrician, Anthony R. Bain, Justin S. Lawley, Jonathan P. Moore, David B. MacLeod, Philip N. Ainslie, Mike Stembridge, Victoria L Meah, Christopher Gasho, Michael M. Tymko, Damian M. Bailey, Tony G. Dawkins, Lydia L. Simpson, Gustavo Vizcardo-Galindo, Joshua C. Tremblay, Benjamin S. Stacey
Publikováno v:
Experimental Physiology. 106:86-103
NEW FINDINGS: What is the central question of this study? Herein, a methodological overview of our research team's (Global REACH) latest high altitude research expedition to Peru is provided. What is the main finding and its importance? The experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c39f9433ce02aa5f53a65078907002
https://doi.org/10.1113/ep088350
https://doi.org/10.1113/ep088350
Autor:
Aimee L. Drane, Christopher Gasho, Stephen A. Busch, Tony G. Dawkins, Michael M. Tymko, Jonathan P. Moore, Andrew R. Steele, Samuel J. Oliver, Lydia L. Simpson, Mike Stembridge, Justin S. Lawley, James D. Anholm, Victoria L Meah, Suman Thapamagar, Craig D. Steinback, P. N. Ainslie
Publikováno v:
The Journal of Physiology. 598:955-965
KEY POINTS In an anaesthetised animal model, independent stimulation of baroreceptors in the pulmonary artery elicits reflex sympathoexcitation. In humans, pulmonary arterial pressure is positively related to basal muscle sympathetic nerve activity (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9a71ae2c5970b8ce35d216b4c612e9
https://doi.org/10.1113/jp278731
https://doi.org/10.1113/jp278731