Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James Clerkin"'
Autor:
Kate Connor, Emer Conroy, Kieron White, Liam P. Shiels, Simon Keek, Abdalla Ibrahim, William M. Gallagher, Kieron J. Sweeney, James Clerkin, David O’Brien, Jane B. Cryan, Philip J. O’Halloran, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry C. Woodruff, Annette T. Byrne
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 GBM cells and longitudinally imaged via contrast enhanced (CE-CT) imag
Externí odkaz:
https://doaj.org/article/f5502ff7e06945ad8173541c1ee43f95
Autor:
Archita Biswas, Manuela Salvucci, Kate Connor, Heiko Düssmann, Steven Carberry, Michael Fichtner, Ellen King, Brona Murphy, A.C O’Farrell, Jane Cryan, Alan Beausang, Josephine Heffernan, Mattia Cremona, Bryan T. Hennessy, James Clerkin, Kieron J. Sweeney, Steve MacNally, F Brett, P O’Halloran, Orna Bacon, Simon Furney, Maite Verreault, Emie Quissac, Franck Bielle, Mohammed H Ahmed, Ahmed Idbaih, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Martine Lamfers, Anna Golebiewska, Frank Hertel, Simone P Niclou, Romain Tching Chi Yen, Andreas Kremer, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Diether Lambrechts, Manasa Kalya P, Alexander Kel, Annette T Byrne, Jochen H.M Prehn
Publikováno v:
Journal of Neuro-Oncology.
Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differenc
Autor:
James Clerkin, Kate Connor, Kieron White, Kieron Sweeney, Liam Shiels, Thomas Van Brussel, Ingrid Arijs, Diether Lambrechts, Stephen Maher, Laure Marignol, Jochen Prehn, David O'Brien, Annette Byrne
Publikováno v:
Neuro-Oncology. 24:vii296-vii297
Clinically faithful pre-clinical models are essential for screening therapies and studying resistance mechanisms. Historically models have failed to predict response in the clinical setting. Current models seldom incorporate surgical resection, and c
Autor:
Kate Connor, Emer Conroy, Kieron White, Liam Shiels, Simon Keek, Abdalla Ibrahim, William Gallagher, James Clerkin, Kieron Sweeney, David O'Brien, Jane Cryan, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry Woodruff, Annette Byrne
Publikováno v:
Neuro-Oncology. 24:vii295-vii296
While magnetic resonance imaging (MRI) is the predominant imaging modality for glioblastoma (GBM), pre-clinical MRI scanner availability is limited. As pre-clinical CT is more widely available and cost-effective, this study aimed to 1) establish prec
Autor:
Manuela Salvucci, Roel G.W. Verhaak, Annette T. Byrne, Maite Verreault, Alice C. O’Farrell, Markus Rehm, Simone P. Niclou, Kate Connor, Kirsten White, James Clerkin, Brona M. Murphy, Donncha F. O’Brien, Martine L.M. Lamfers, J.H.M. Prehn, Ahmed Idbaih, Anna Golebiewska
Publikováno v:
Annals of Oncology
Annals of Oncology, 31(12), 1679-1692. Elsevier Ltd.
Annals of Oncology, 31(12), 1679-1692. Elsevier Ltd.
Glioblastoma represents the most common primary malignancy of the central nervous system in adults and remains a largely incurable disease. The elucidation of disease subtypes based on mutational profiling, gene expression and DNA methylation has so
Autor:
Kate Connor, Emer Conroy, Kieron White, Liam Shiels, William M Gallagher, Simon Keek, Abdalla Ibrahim, James Clerkin, David O’Brien, Philippe Lambin, Henry C Woodruff, Annette Byrne
Publikováno v:
WFNOS 2022 Abstract Book.
Autor:
Kieron White, Henry C. Woodruff, Emer Conroy, Philippe Lambin, Kate Connor, David O’Brien, James Clerkin, Annette T. Byrne, Liam Shiels, Simon Keek, William M. Gallagher, Abdalla Ibrahim
Publikováno v:
Neuro Oncol
Despite magnetic resonance imaging (MRI) being the gold-standard imaging modality in the glioblastoma (GBM) setting, the availability of rodent MRI scanners is relatively limited. CT is a clinically relevant alternative which is more widely available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f88b53c6631344f107cab67f33270e8
https://europepmc.org/articles/PMC7651040/
https://europepmc.org/articles/PMC7651040/
Autor:
James Clerkin, Ramez W. Kirollos, Diana Fitzroll, Abel Devadass, Kieren Allinson, Michael Farrell, Adam Young, Philip J. O’Halloran, Mohsen Javadpour, Michael D. Jenkinson, Mathew R. Guilfoyle, Karol P. Budohoski, Christopher P. Millward, Mueez Waqar, Thomas Santarius, Seamus Looby
BACKGROUND: Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit a high recurrence rate, some pursue a more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c397e49f1301f55f1afd721f4e482688
https://europepmc.org/articles/PMC6217316/
https://europepmc.org/articles/PMC6217316/
Autor:
Stephen G. Maher, Kieron White, Liam Shiels, Kieron J. Sweeney, Annette T. Byrne, James Clerkin, Jochen H. M. Prehn, Laure Marignol, Kate Connor, David O’Brien
Publikováno v:
Neuro Oncol
GBM is a devastating disease with peak incidence in the seventh decade. Pre-clinical models are essential for studying resistance mechanisms and screening novel therapies. However, historically these models have failed to predict response in humans.
Autor:
Diana Fitzroll, Karol P. Budohoski, Kieren Allinson, Seamus Looby, Ramez W. Kirollos, Thomas Santarius, Michael D. Jenkinson, Mueez Waqar, Michael Farrell, James Clerkin, Mathew R. Guilfoyle, Christopher P. Millward, Abel Devadass, Adam Young, Philip J. O’Halloran, Mohsen Javadpour
Publikováno v:
ACTA NEUROCHIRURGICA
Acta Neurochirurgica
Acta Neurochirurgica
Background Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit a high recurrence rate, some pursue a more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf37a87a4d99d9f1125a665e12ed405