Zobrazeno 1 - 10
of 63
pro vyhledávání: '"James Cantley"'
Autor:
Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103117- (2024)
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively reg
Externí odkaz:
https://doaj.org/article/174bdfaa05484649a9d4e82ff51fecbf
Publikováno v:
BioMedical Engineering OnLine, Vol 22, Iss 1, Pp 1-22 (2023)
Abstract Freezing-of-gait (FOG) and impaired walking are common features of Parkinson’s disease (PD). Provision of external stimuli (cueing) can improve gait, however, many cueing methods are simplistic, increase task loading or have limited utilit
Externí odkaz:
https://doaj.org/article/86a3b8c749244ed4969748380b81b8c1
Autor:
Nancy Sue, Le May Thai, Atsushi Saito, Cierra K. Boyer, Ashleigh M. Fordham, Chenxu Yan, Aimee Davenport, Jiang Tao, Mohammed Bensellam, James Cantley, Yan-Chuan Shi, Samuel B. Stephens, Kazunori Imaizumi, Trevor J. Biden
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101845- (2024)
Objective: Although individual steps have been characterized, there is little understanding of the overall process whereby glucose co-ordinates the biosynthesis of insulin with its export out of the endoplasmic reticulum (ER) and incorporation into i
Externí odkaz:
https://doaj.org/article/abf43cfa76f149028ed91ecd5b7f85a5
Autor:
Sing-Young Chen, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Derek Y.H. Wong, Stephanie J. Alexopoulos, Isabella Aleksovska, Joseph M. Salamoun, Christopher J. Garcia, Blake J. Cochran, Kerry-Anne Rye, Greg C. Smith, Frances L. Byrne, Margaret J. Morris, Webster L. Santos, James Cantley, Kyle L. Hoehn
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101684- (2023)
Objective: Calorie restriction is a first-line treatment for overweight individuals with metabolic impairments. However, few patients can adhere to long-term calorie restriction. An alternative approach to calorie restriction that also causes negativ
Externí odkaz:
https://doaj.org/article/e475640495114e8b9f51a21417a66099
Autor:
Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya N. Tebeka, Laurène Vetterli, Ekaterina Yonova-Doing, Fiona Gribble, Frank Reimann, Kyle L. Hoehn, Piers A. Hemsley, Jonas Ahnfelt-Rønne, Patrik Rorsman, Quan Zhang, Heidi de Wet, James Cantley
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation of critical glucose-sensing proteins. Loss of ACC1 in pancreatic alpha-cell
Externí odkaz:
https://doaj.org/article/166afa66325d42c88ebcf56718483f72
Autor:
Weiyu Chen, Sergey Tumanov, Daniel J. Fazakerley, James Cantley, David E. James, Louise L. Dunn, Taqi Shaik, Cacang Suarna, Roland Stocker
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102152- (2021)
Background & aims: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans. Bilirubi
Externí odkaz:
https://doaj.org/article/41af8d9bb78949eebc861578f2f815f1
Autor:
Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M. Johnson, Alpesh Thakker, Rula Bany Bakar, Rebecca L. Westbrook, Jonathan P. Barlow, Monica Hoang, Jamie W. Joseph, Gareth G. Lavery, Ildem Akerman, James Cantley, Leanne Hodson, Daniel A. Tennant, David J. Hodson
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The α-ketoglutarate–dependent dioxygenase, prolyl-4-hydroxylase 3 (PHD3), is an HIF target that uses molecular oxygen to hydroxylate peptidyl prolyl residues. Although PHD3 has been reported to influence cancer cell metabolism and liver insulin se
Externí odkaz:
https://doaj.org/article/1bf081e6aea049debb7985fde804b9c9
Autor:
Sing-Young Chen, Ellen M. Olzomer, Martina Beretta, James Cantley, Craig S. Nunemaker, Kyle L. Hoehn, Frances L. Byrne
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9798 (2022)
Obesity-related insulin resistance is a highly prevalent and growing health concern, which places stress on the pancreatic islets of Langerhans by increasing insulin secretion to lower blood glucose levels. The glucose transporters GLUT1 and GLUT3 pl
Externí odkaz:
https://doaj.org/article/11e2c49c4e454001b9ee519897b80eb4
Autor:
Kim Loh, Yan-Chuan Shi, Stacey Walters, Mohammed Bensellam, Kailun Lee, Katsuya Dezaki, Masanori Nakata, Chi Kin Ip, Jeng Yie Chan, Esteban N. Gurzov, Helen E. Thomas, Michaela Waibel, James Cantley, Thomas W. Kay, Toshihiko Yada, D. Ross Laybutt, Shane T. Grey, Herbert Herzog
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition
Externí odkaz:
https://doaj.org/article/99ec06e40ce64866b58ef492f2dc58bd
Autor:
James Cantley, Frances M. Ashcroft
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-1 (2019)
Upon publication of the original article [1], the authors noticed that they had accidently omitted to acknowledge funding from the European Research Council.
Externí odkaz:
https://doaj.org/article/a47d92318a4448d2b94a862f38984e8c