Zobrazeno 1 - 10
of 68
pro vyhledávání: '"James Cai"'
Autor:
Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J. Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H. Sterman, J. T. Poirier, Ben Neel, Kwok-Kin Wong, Luis Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N. Segal, Andre L. Moreira, Harvey I. Pass, Aristotelis Tsirigos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Approximately 30% of early-stage lung adenocarcinoma patients present with disease progression after successful surgical resection. Despite efforts of mapping the genetic landscape, there has been limited success in discovering predictive bi
Externí odkaz:
https://doaj.org/article/326ae301e3024de2b6652801e0ebede8
Autor:
Vedant Das Swain, Jiajia Xie, Maanit Madan, Sonia Sargolzaei, James Cai, Munmun De Choudhury, Gregory D. Abowd, Lauren N. Steimle, B. Aditya Prakash
Publikováno v:
Frontiers in Digital Health, Vol 5 (2023)
Infectious diseases, like COVID-19, pose serious challenges to university campuses, which typically adopt closure as a non-pharmaceutical intervention to control spread and ensure a gradual return to normalcy. Intervention policies, such as remote in
Externí odkaz:
https://doaj.org/article/3d530c62fc95406aa5c2fd8bd25ffd65
Autor:
Douglas L. Fink, James Cai, Matthew V. X. Whelan, Christopher Monit, Carlos Maluquer de Motes, Greg J. Towers, Rebecca P. Sumner
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF-κB transcription factors by viral pathogen-associated molecular patterns, such
Externí odkaz:
https://doaj.org/article/83664ea4d57d46588314b53c167d7d2b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 8 (2016)
Human aging is associated with cognitive decline and an increased risk of neurodegenerative disease. Our objective for this study was to evaluate potential relationships between age and variation in gene expression across different regions of the bra
Externí odkaz:
https://doaj.org/article/cf46d31ab5754ce68a305494005a79d8
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40946 (2012)
With the large amount of pharmacological and biological knowledge available in literature, finding novel drug indications for existing drugs using in silico approaches has become increasingly feasible. Typical literature-based approaches generate new
Externí odkaz:
https://doaj.org/article/2fd686fdafb44556945f0c76903058ca
Autor:
Douglas L. Fink, David A. Oladele, Abigail J. Slack, Oluwatosin Odubela, Tomilola Musari-Martins, Adaobi Okechukwu, Kemi Adetayo, Sola Opaneye, Rufai Abubakar, Agatha David, James Cai, Shumonta Quaderi, Ibrahim Abubakar, Oliver Ezechi, John R. Hurst, Marc Lipman, Babatunde Salako
Publikováno v:
AIDS. 36:1987-1995
HIV and tuberculosis (TB) are risk factors for non-communicable chronic lung disease (CLD). Despite the high prevalence of these infections in West Africa, there are no studies that compare CLD between people with HIV and HIV-negative populations in
Autor:
Hernan Bazan, Surjyadipta Bhattacharjee, Madigan Reid, Bokkyoo Jun, Connor Polk, Madeleine Strain, Linsey St Pierre, Neehar Desai, Patrick Daly, Jessica Cucinello-Ragland, Scott Edwards, Julio Alvarez-Builla, James Cai, Nicolas Bazan
The safe and effective management of pain is a critical healthcare and societal need. The potential for misuse and addiction associated with opioids, nephrotoxicity, and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bfb534d50f07684987c3937aaba45b0
https://doi.org/10.21203/rs.3.rs-2883310/v1
https://doi.org/10.21203/rs.3.rs-2883310/v1
Autor:
John F. Boylan, David Heimbrook, Kelli Glenn, Helmut Jacobsen, Roland Jakob-Røtne, Alexander Flohr, Michael Linn, Holly Hilton, Windy Berkofsky-Fessler, James Cai, John Roberts, Daisy Carvajal, Maria Vilenchik, Kathryn Packman, Melissa Smith, Wei He, Leopoldo Luistro
Supplementary Methods and Materials from Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f83d7f21ed746ea9de9d9e721b1ff51
https://doi.org/10.1158/0008-5472.22382880
https://doi.org/10.1158/0008-5472.22382880
Autor:
John F. Boylan, David Heimbrook, Kelli Glenn, Helmut Jacobsen, Roland Jakob-Røtne, Alexander Flohr, Michael Linn, Holly Hilton, Windy Berkofsky-Fessler, James Cai, John Roberts, Daisy Carvajal, Maria Vilenchik, Kathryn Packman, Melissa Smith, Wei He, Leopoldo Luistro
Supplementary Figure 2 from Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521897168f201bde5991eb3d55c7b264
https://doi.org/10.1158/0008-5472.22382883.v1
https://doi.org/10.1158/0008-5472.22382883.v1
Autor:
John F. Boylan, David Heimbrook, Kelli Glenn, Helmut Jacobsen, Roland Jakob-Røtne, Alexander Flohr, Michael Linn, Holly Hilton, Windy Berkofsky-Fessler, James Cai, John Roberts, Daisy Carvajal, Maria Vilenchik, Kathryn Packman, Melissa Smith, Wei He, Leopoldo Luistro
Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of γ-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b590f8f74623298092a9047a0367925c
https://doi.org/10.1158/0008-5472.c.6500352
https://doi.org/10.1158/0008-5472.c.6500352