Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James C. Wisowaty"'
Autor:
John J. Savarese, James C. Wisowaty, William B. Wastila, Patel Sanjay Shashikant, R. Brandt Maehr, Mary M. Jackson
Publikováno v:
European Journal of Pharmaceutical Sciences. 5:253-266
The purpose of this work was to identify a new ultra-short-acting neuromuscular blocking agent devoid of the potential to produce cardiovascular effects at ≥ED 9 5 doses. Four new bis -quaternary mivacurium analogues that are acyclic with respect t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e7a37bca8e12526d97b045aac15ab73
https://doi.org/10.1016/s0928-0987(97)00020-1
https://doi.org/10.1016/s0928-0987(97)00020-1
Autor:
William B. Wastila, R. Brandt Maehr, Patel Sanjay Shashikant, John J. Savarese, James C. Wisowaty
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:63-71
The purpose of this work was to identify a new ultra-short-acting neuromuscular blocking agent devoid of the potential to produce histamine-like cardiovascular effects at ≥ED 95 doses. Eight new bis -4-benzyltetrahydroisoquinolinium esters, derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4edf23fd65516c4a3e4ac8e0be33232
https://doi.org/10.1016/0928-0987(95)00032-1
https://doi.org/10.1016/0928-0987(95)00032-1
Publikováno v:
Journal of Heterocyclic Chemistry. 32:1011-1017
The assignment of the proton spectrum of 3′,4′-anhydrovinblastine is reported. Assignments are made for several protons for which only approximate assignments were available previously. Homonuclear TOCSY and ROESY spectra were utilized in conjunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7660fe22065498201d22633f3c5fca
https://doi.org/10.1002/jhet.5570320357
https://doi.org/10.1002/jhet.5570320357
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:1119-1130
Piritrexim 1(2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]-pyrimidine) was synthesized in the [14C]-labelled form with specific activity 50.8 mCi/mmol suitable for drug metabolism, transport, dispostion and mechanism of action studies. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d6375a9a493999623fedbd0fef2837
https://doi.org/10.1002/jlcr.2580331206
https://doi.org/10.1002/jlcr.2580331206
Autor:
James C. Wisowaty, John A. Hill
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 28:811-818
1-(3,4-Dichlorophenyl)-3-(methylamino)propanol hydrochloride, 1, a potential antidepressant, was synthesized by a two-step method in the [3H]-labelled form with specific activity 12.5 mCi/mmol suitable for drug metabolism and disposition studies (1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33b9b7cf80e4bb6a42805f67cbe25688
https://doi.org/10.1002/jlcr.2580280710
https://doi.org/10.1002/jlcr.2580280710
Autor:
Stephen William Rafferty, Greg A. Erickson, Richard T. Matsuoka, James C. Wisowaty, Barry R. Sickles, Matthew J. Sharp, Jiasheng Guo, Russ N. Fitzgerald
Publikováno v:
The Journal of organic chemistry. 71(21)
An efficient synthesis of 2-{4-[({4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)thio]phenoxy}-2-methylpropanoic acid (1), a potent PPARpan agonist, is described. The seven-step synthesis, which af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a1204761df38c67d921f2aa760a447
https://pubmed.ncbi.nlm.nih.gov/17025332
https://pubmed.ncbi.nlm.nih.gov/17025332
Autor:
John S. Walsh, Mir Hashim, Michael Tolar Martin, David Kendall Jung, Gary D. Bowers, Virgil L. Styles, Istvan Kaldor, Caroline L. Moseley, John A. Ray, Vicente Samano, Randy D. Rutkowske, Cecilia S. Koble, Timothy D. Spitzer, Patel Sanjay Shashikant, Eric E. Boros, Andrea M. Sefler, G. Evan Boswell, James C. Wisowaty, Matthew R. Belmont, Mindy J. Reese, Paul L. Feldman, James B. Thompson, Robert A. Mook, Eric C. Bigham, John J. Savarese
Publikováno v:
Journal of medicinal chemistry. 46(12)
Structure-activity relationships in rhesus monkeys for a novel mixed-onium class of ultra-short-acting nondepolarizing tetrahydroisoquinolinium neuromuscular blockers (NMBs) are described. Bis-onium chlorofumarate 20a with (1R,2S)-benzyltetrahydroiso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a53d6f4ad55fda401dbe78fe5f016b
https://pubmed.ncbi.nlm.nih.gov/12773054
https://pubmed.ncbi.nlm.nih.gov/12773054
Autor:
Mir Hashim, Paul L. Feldman, James B. Thompson, Patel Sanjay Shashikant, Samano, John J. Savarese, John A. Ray, Eric C. Bigham, Boswell Grady Evan, Eszter Boros, Robert A. Mook, James C. Wisowaty
Publikováno v:
Journal of medicinal chemistry. 42(2)
Introduction. Neuromuscular blocking agents (NMBs)1 are used as adjuncts to anesthesia to provide skeletal muscle relaxation during surgery and to facilitate tracheal intubation. Emergency tracheal intubation maneuvers are routinely accomplished with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4dc23e840124e9fd09f17a39e6af0c
https://pubmed.ncbi.nlm.nih.gov/9925724
https://pubmed.ncbi.nlm.nih.gov/9925724
Autor:
Hassan A. El-Sayad, Roy A. Swaringen, Ellen L. Stewart, Michael E. Darnofall, David A. Yeowell, James C. Wisowaty
Publikováno v:
The Journal of Organic Chemistry. 44:4825-4829
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b49d681b30b0d6b8a2878dae5945b28
https://doi.org/10.1021/jo00394a017
https://doi.org/10.1021/jo00394a017
Autor:
James C. Wisowaty, D. W. H. MacDowell
Publikováno v:
The Journal of Organic Chemistry. 36:4004-4012
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fabc51bd9d00c64c6b02b73445bc78fc
https://doi.org/10.1021/jo00825a002
https://doi.org/10.1021/jo00825a002