Zobrazeno 1 - 10
of 72
pro vyhledávání: '"James C. Williamson"'
Autor:
Paul J. Lehner, Frank McCaughan, Edward J.D. Greenwood, Thomas W.M. Crozier, Wenrui Guo, James C. Williamson, Ildar Gabaev, Linsey M. Porter, Guinevere L. Grice, Ana Teixeira-Silva, Richard J. Stanton, Arthur Wickenhagen, Sam J. Wilson, Eddie C. Y. Wang, James A. Nathan, Nicholas J. Matheson
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Quantitative proteomics is able to provide a comprehensive, unbiased description of changes to cells caused by viral infection, but interpretation may be complicated by differential changes in infected and uninfected ‘bystander’ cells
Externí odkaz:
https://doaj.org/article/ebbb57c2f26649a4b38fb103c69777b6
Autor:
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-depen
Externí odkaz:
https://doaj.org/article/ec9909b7b0774e2691625135a2850ac1
Autor:
Taylor Boggess, James C. Williamson, Ethan B. Niebergall, Hannah Sexton, Anna Mazur, Richard D. Egleton, Lawrence M. Grover, W. Christopher Risher
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
The rise in rates of opioid abuse in recent years in the United States has led to a dramatic increase in the incidence of neonatal abstinence syndrome (NAS). Despite improved understanding of NAS and its acute symptoms, there remains a paucity of inf
Externí odkaz:
https://doaj.org/article/6554d2ee60854fc2980f27cd3f0b0129
Autor:
Lior Soday, Martin Potts, Leah M. Hunter, Benjamin J. Ravenhill, Jack W. Houghton, James C. Williamson, Robin Antrobus, Mark R. Wills, Nicholas J. Matheson, Michael P. Weekes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry
Externí odkaz:
https://doaj.org/article/fd64e47b9b4b4f72b97a7e62b277b2d8
Autor:
Maurizio Mangolini, Frederik Götte, Andrew Moore, Tim Ammon, Madlen Oelsner, Gloria Lutzny-Geier, Ludger Klein-Hitpass, James C. Williamson, Paul J. Lehner, Jan Dürig, Michael Möllmann, Lívia Rásó-Barnett, Katherine Hughes, Antonella Santoro, Simón Méndez-Ferrer, Robert A. J. Oostendorp, Ursula Zimber-Strobl, Christian Peschel, Daniel J. Hodson, Marc Schmidt-Supprian, Ingo Ringshausen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β
Externí odkaz:
https://doaj.org/article/c4f9c099f3104cabbf026773512a17d1
Autor:
Edward J.D. Greenwood, James C. Williamson, Agata Sienkiewicz, Adi Naamati, Nicholas J. Matheson, Paul J. Lehner
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1579-1596.e7 (2019)
Summary: HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and Nef, w
Externí odkaz:
https://doaj.org/article/6556ee5886a245168009f767f06fe6d3
Autor:
Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J. Lehner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
CRISPR/Cas9-mediated forward genetic screens and gene-trap mutagenesis screens in haploid cells are both powerful techniques to examine gene function. Here, the authors show the two approaches have high concordance and identify an uncharacterized gen
Externí odkaz:
https://doaj.org/article/ace455e4f2ee40ba943423c1d8c92321
Autor:
David A. Rhodes, Hung-Chang Chen, James C. Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J. Lehner, Thomas Herrmann, Matthias Eberl
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Activation of human Vγ9/Vδ2 T cells by “phosphoantigens” (pAg), the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) and the endogenous isoprenoid intermediate isopentenyl pyrophosphate, requires expression of butyr
Externí odkaz:
https://doaj.org/article/323f7b2de5564dc89eec8dc2fcab20fe
Autor:
Lyra O. Randzavola, Paige M. Mortimer, Emma Garside, Elizabeth R. Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C. Williamson, Shreehari Suresh, John M. Sowerby, Misaki Matsumoto, Celio X.C. Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, Will M. Rae, Gordon J. Dougan, John Grainger, Paul J. Lehner, Michael Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth G. C. Smith, Francesca Magnani, David C. Thomas
Publikováno v:
eLife. 11
Peer reviewed: True
EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, c
EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c934130541714344898a5b7d8fe25a6
https://doi.org/10.7554/elife.76387
https://doi.org/10.7554/elife.76387
Autor:
Paige M Mortimer, Lyra O Randzavola, Emma Garside, Elizabeth R Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C Williamson, Shreehari Suresh, John M Sowerby, Misaki Matsumoto, Celio XC Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, William M Rae, Gordon J Dougan, John Grainger, Paul J Lehner, Michael A Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth GC Smith, Francesca Magnani, David C Thomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed7b8a23462d0bf93707f8ec4f553fd
https://doi.org/10.7554/elife.76387.sa2
https://doi.org/10.7554/elife.76387.sa2
