Zobrazeno 1 - 10
of 77
pro vyhledávání: '"James C. W. Locke"'
Autor:
Paul K. Grant, Gregory Szep, Om Patange, Jacob Halatek, Valerie Coppard, Attila Csikász-Nagy, Jim Haseloff, James C. W. Locke, Neil Dalchau, Andrew Phillips
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Morphogen gradients can be dynamic and transient yet give rise to stable cellular patterns. Here the authors show that a synthetic morphogen-induced mutual inhibition circuit produces stable boundaries when the spatial average of morphogens falls wit
Externí odkaz:
https://doaj.org/article/16fc968713644a57910ee1bc73fd0b96
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells. Here, the authors show that stochastic pulsing in the expression of a sigma factor enables the formation of spatial patterns in a
Externí odkaz:
https://doaj.org/article/6aa272885b94430e8fb8948867d55070
Autor:
Om Patange, Christian Schwall, Matt Jones, Casandra Villava, Douglas A. Griffith, Andrew Phillips, James C. W. Locke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Noisy gene expression leading to phenotypic variability can help organisms to survive in changing environments. Here, Patange et al. show that noisy expression of a stress response regulator, RpoS, allows E. coli cells to modulate their growth rates
Externí odkaz:
https://doaj.org/article/9e91aadcaffe440b96bf4b0df8cd6cb8
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Co-expression networks are a powerful tool to understand gene regulation. They have been used to identify new regulation and function of genes involved in plant development and their response to the environment. Up to now, co-expression networks have
Externí odkaz:
https://doaj.org/article/8dc1f8e39fad47d8bb838b8d2a6c2611
Autor:
Noga Mosheiff, Bruno M. C. Martins, Sivan Pearl-Mizrahi, Alexander Grünberger, Stefan Helfrich, Irina Mihalcescu, Dietrich Kohlheyer, James C. W. Locke, Leon Glass, Nathalie Q. Balaban
Publikováno v:
Physical Review X, Vol 8, Iss 2, p 021035 (2018)
Periodic forcing of nonlinear oscillators leads to a large number of dynamic behaviors. The coupling of the cell cycle to the circadian clock provides a biological realization of such forcing. A previous model of forcing leads to nontrivial relations
Externí odkaz:
https://doaj.org/article/cd823f4190fa4f9eba70cc4d098a45f4
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 3, Pp 1-15 (2022)
Abstract Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day‐night cycle. Mathematical models of the clock are typically either “whole‐plant” that ignore tissue or cell type‐specif
Externí odkaz:
https://doaj.org/article/beee693c15184f40b28fa8312cadb051
Autor:
Christian P Schwall, Torkel E Loman, Bruno M C Martins, Sandra Cortijo, Casandra Villava, Vassili Kusmartsev, Toby Livesey, Teresa Saez, James C W Locke
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 7, Pp 1-16 (2021)
Abstract Genetically identical individuals in bacterial populations can display significant phenotypic variability. This variability can be functional, for example by allowing a fraction of stress prepared cells to survive an otherwise lethal stress.
Externí odkaz:
https://doaj.org/article/69c0b08003614400b39971bb6826f28a
Publikováno v:
Plant Physiology. 190:938-951
Like many organisms, plants have evolved a genetic network, the circadian clock, to coordinate processes with day/night cycles. In plants, the clock is a pervasive regulator of development and modulates many aspects of physiology. Clock-regulated pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929c1aade96f2cc96ebf253320ead2d5
https://doi.org/10.1093/plphys/kiac236
https://doi.org/10.1093/plphys/kiac236
Autor:
Heather M Meyer, José Teles, Pau Formosa-Jordan, Yassin Refahi, Rita San-Bento, Gwyneth Ingram, Henrik Jönsson, James C W Locke, Adrienne H K Roeder
Publikováno v:
eLife, Vol 6 (2017)
Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we s
Externí odkaz:
https://doaj.org/article/89a8d3b5eb77485cac7874e5480dbb50
Autor:
James C. W. Locke, Mark Greenwood
Publikováno v:
Current Opinion in Plant Biology. 53:65-72
The circadian clock is a genetic circuit that allows organisms to anticipate daily events caused by the rotation of the Earth. The plant clock regulates physiology at multiple scales, from cell division to ecosystem-scale interactions. It is becoming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56465d597e083d78205cdb8d0c1b1f5
https://doi.org/10.1016/j.pbi.2019.09.004
https://doi.org/10.1016/j.pbi.2019.09.004