Zobrazeno 1 - 10
of 30
pro vyhledávání: '"James C. Stroud"'
The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity
Autor:
Arthur Laganowsky, Michael R. Sawaya, Carol V. Robinson, Heath Ecroyd, Justin L. P. Benesch, Duilio Cascio, Miranda P. Collier, Georg K. A. Hochberg, James C. Stroud, John A. Carver, David Eisenberg, Dezerae Cox, Andrew Baldwin, Cong Liu
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 16
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 16
Mammalian small heat-shock proteins (sHSPs) are molecular chaperones that form polydisperse and dynamic complexes with target proteins, serving as a first line of defense in preventing their aggregation into either amorphous deposits or amyloid fibri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a238381d2aff0a13ae2ce782d1375d68
https://ora.ox.ac.uk/objects/uuid:f31e4acf-b125-4c6c-9d57-f6be25893aa5
https://ora.ox.ac.uk/objects/uuid:f31e4acf-b125-4c6c-9d57-f6be25893aa5
Publikováno v:
Proceedings of the National Academy of Sciences. 109:7717-7722
Although amyloid fibers are found in neurodegenerative diseases, evidence points to soluble oligomers of amyloid-forming proteins as the cytotoxic species. Here, we establish that our preparation of toxic amyloid-β 1–42 (Abeta42) fibrillar oligome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a1d668dfb6b1c01a331ed5a6384175
https://doi.org/10.1073/pnas.1203193109
https://doi.org/10.1073/pnas.1203193109
Publikováno v:
Journal of Molecular Biology. 393:98-112
The activation and latency of human immunodeficiency virus type 1 (HIV-1) are tightly controlled by the transcriptional activity of its long terminal repeat (LTR) region. The LTR is regulated by viral proteins as well as host factors, including the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdab608386c8f926624f26291d4ea76
https://doi.org/10.1016/j.jmb.2009.08.023
https://doi.org/10.1016/j.jmb.2009.08.023
Autor:
Kristen K. B. Barthel, Reza Kalhor, James C. Stroud, Lin Chen, Michael J. Giffin, Darren L. Bates, Yongqing Wu
Publikováno v:
Structure. 16:684-694
The host factor, nuclear factor of activated T-cells (NFAT), regulates the transcription and replication of HIV-1. Here, we have determined the crystal structure of the DNA binding domain of NFAT bound to the HIV-1 long terminal repeat (LTR) tandem k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d73261b6b4e9fa2fc0f5787a2aa809
https://doi.org/10.1016/j.str.2008.01.020
https://doi.org/10.1016/j.str.2008.01.020
Publikováno v:
Channels. 1:234-237
Neurotoxins from snake venoms act as potent antagonists on the nicotinic acetylcholine receptors (nAChRs). Alpha-neurotoxins such as alpha-bungarotoxin (alpha-Btx) selectively bind to the skeletal muscle nAChRs among other subtypes, causing failure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f8ec0213e228e4b4a22e4c9791a301
https://doi.org/10.4161/chan.4909
https://doi.org/10.4161/chan.4909
Autor:
Katja Nowick, Darren L. Bates, James C. Stroud, Lin Chen, Yongqing Wu, Svante Pääbo, Aidong Han, Harry Tong
Publikováno v:
Structure
Summary FOXP (FOXP1–4) is a newly defined subfamily of the forkhead box (FOX) transcription factors. A mutation in the FOXP2 forkhead domain cosegregates with a severe speech disorder, whereas several mutations in the FOXP3 forkhead domain are link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894cb735ea6b5e7588ddc7fecba663d2
Publikováno v:
Reading Research and Instruction. 44:49-60
This study examined the efficacy of using an integrated learning system (ILS) to augment kindergarten emergent reading skills. This quasi‐experimental design used repeated measures. Change scores were calculated to run analyses. Effect sizes were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1810c8e40ea97656f44b78ec383fdcbf
https://doi.org/10.1080/19388070509558436
https://doi.org/10.1080/19388070509558436
Autor:
Thomas Lee, Yukihito Kabuyama, Katheryn A. Resing, Natalie G. Ahn, Elizabeth J. Goldsmith, Lin Chen, Andrew N. Hoofnagle, Xiaoshan Min, James C. Stroud
Publikováno v:
Molecular Cell. 14:43-55
Protein interactions between MAP kinases and substrates, activators, and scaffolding proteins are regulated by docking site motifs, one containing basic residues proximal to Leu-X-Leu (DEJL) and a second containing Phe-X-Phe (DEF). Hydrogen exchange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85c363bb968d3799794cc50bdf57dac
https://doi.org/10.1016/s1097-2765(04)00161-3
https://doi.org/10.1016/s1097-2765(04)00161-3
Autor:
Lin Chen, Konstanze D von Koenig, Darren L. Bates, Michael J. Giffin, John W. Hardin, James C. Stroud
Publikováno v:
Nature Structural & Molecular Biology. 10:800-806
DNA binding by NFAT1 as a dimer has been implicated in the activation of host and viral genes. Here we report a crystal structure of NFAT1 bound cooperatively as a dimer to the highly conserved kappa B site from the human immunodeficiency virus 1 (HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90839a4c11e76c7be64e71f00066fa44
https://doi.org/10.1038/nsb981
https://doi.org/10.1038/nsb981
Autor:
James C. Stroud, Patricia Clark
Publikováno v:
Early Child Development and Care. 172:55-63
This study examines the impact of a professional development school (PDS) partnership between a university and two early childhood centers on the quality of care and education within the programs. The Early Childhood Environment Rating Scale (Harms,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63d3e339b9e06fe800f98d258f07536b
https://doi.org/10.1080/03004430210876
https://doi.org/10.1080/03004430210876