Zobrazeno 1 - 10
of 87
pro vyhledávání: '"James C. Stone"'
Autor:
Xiaohua Song, Ana Lopez-Campistrous, Lucy Sun, Nancy A Dower, Noemi Kedei, Jing Yang, Jessica S Kelsey, Nancy E Lewin, Tim E Esch, Peter M Blumberg, James C Stone
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72331 (2013)
Ingenol-3-angelate (I3A) is a non-tumor promoting phorbol ester-like compound identified in the sap of Euphoria peplus. Similar to tumor promoting phorbol esters, I3A is a diacylglycerol (DAG) analogue that binds with high affinity to the C1 domains
Externí odkaz:
https://doaj.org/article/4f9d2b403168453499b6bf3f80e2e1ab
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53300 (2013)
T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the thymus, the earliest thymic progenitors, called CD4(-)CD8(-) 'double negative' (DN) thymocy
Externí odkaz:
https://doaj.org/article/041b7b2df2af44b8a47fb179bcc25d36
Autor:
Deirdre M Fuller, Minghua Zhu, Xiaohua Song, Chih-wen Ou-Yang, Sarah A Sullivan, James C Stone, Weiguo Zhang
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38796 (2012)
The Ras-guanyl nucleotide exchange factor RasGRP1 plays a critical role in T cell receptor-mediated Erk activation. Previous studies have emphasized the importance of RasGRP1 in the positive selection of thymocytes, activation of T cells, and control
Externí odkaz:
https://doaj.org/article/658adb15fcbb48ad9e751040c174fadf
Publikováno v:
European Journal of Immunology. 44:1535-1540
The duration and/or the magnitude of Ras-Erk activation are known to be crucial for cell-fate decisions. In T cells, sustained Erk activation correlates with differentiation/proliferation, whereas transient Erk activation parallels with unresponsiven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c84c2c5e7fd0ed87675e254f9c7ab5b9
https://doi.org/10.1002/eji.201344046
https://doi.org/10.1002/eji.201344046
Autor:
Lauren L. Fonseca, J. Mark Cline, Yuka Endo, Cynthia Rajani, Joe W. Ramos, James C. Stone, Junfang Ji, Amrish Sharma, Jodi K. Yanagida, Patricia S. Lorenzo
Publikováno v:
Carcinogenesis. 35:1084-1091
Ras is frequently activated in cutaneous squamous cell carcinoma, a prevalent form of skin cancer. However, the pathways that contribute to Ras-induced transformation have not been entirely elucidated. We have previously demonstrated that in transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1255ac1e2fd1c6cfea83541a7ac1a905
https://doi.org/10.1093/carcin/bgu016
https://doi.org/10.1093/carcin/bgu016
Autor:
Burkhart Schraven, Boerge Arndt, Bhavani S Kowtharapu, Luca Simeoni, Mateusz Poltorak, James C. Stone, Nicole Warnecke
Publikováno v:
EMBO reports
EMBO reports; Vol 13
EMBO reports; Vol 13
Sos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06077d42449e4933ffc64e79784ac0a4
Publikováno v:
The Journal of Immunology. 187:4467-4473
The invariant NKT (iNKT) cell lineage contains CD4+ and CD4− subsets. The mechanisms that control such subset differentiation and iNKT cell maturation in general have not been fully understood. RasGRP1, a guanine nucleotide exchange factor for TCR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bde44a98a7fffe818add30d32cec064a
https://doi.org/10.4049/jimmunol.1003798
https://doi.org/10.4049/jimmunol.1003798
Autor:
Hung Sia Teh, Lauren A. Zenewicz, Xiaoxi Chen, John J. Priatel, James C. Stone, Hao Shen, Jason J. Coughlin, Michael T. Chow, Rusung Tan, Yu-Hsuan Huang
Publikováno v:
The Journal of Immunology. 184:666-676
Ag encounter by naive CD8 T cells initiates a developmental program consisting of cellular proliferation, changes in gene expression, and the formation of effector and memory T cells. The strength and duration of TCR signaling are known to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8e0a646b73858375779b831d602f68
https://doi.org/10.4049/jimmunol.0803521
https://doi.org/10.4049/jimmunol.0803521
Autor:
Ho Y. Poon, James C. Stone
Publikováno v:
Biochemical and Biophysical Research Communications. 390:1395-1401
In leukocytes, diacylglycerol (DAG) regulates the small GTPase Ras through the agency of Ras guanyl releasing proteins (RasGRPs). Ras is thought to regulate phosphatidylinositol 3-kinase (PI3K). Therefore, DAG signaling is hypothesized to impact PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47c3c50e95263e4eab2145c9fea4d60
https://doi.org/10.1016/j.bbrc.2009.11.004
https://doi.org/10.1016/j.bbrc.2009.11.004
Autor:
J. Mark Cline, Federico R. Diez, Ann A. Garrido, Courtney T. Luke, Amrish Sharma, Patricia S. Lorenzo, James C. Stone, Nancy A. Dower
Publikováno v:
The American Journal of Pathology. 175:392-399
Models of epidermal carcinogenesis have demonstrated that Ras is a critical molecule involved in tumor initiation and progression. Previously, we have shown that RasGRP1 increases the susceptibility of mice to skin tumorigenesis when overexpressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::114c7aeb0479111d4a4c6feb51b3774d
https://doi.org/10.2353/ajpath.2009.090036
https://doi.org/10.2353/ajpath.2009.090036