Zobrazeno 1 - 10
of 637
pro vyhledávání: '"James C. Smith"'
Publikováno v:
Wellcome Open Research, Vol 7 (2023)
The zebrafish (Danio rerio), is an important biomedical model organism used in many disciplines, including development, disease modeling and toxicology, to better understand vertebrate biology. The phenomenon of developmental delay in zebrafish embry
Externí odkaz:
https://doaj.org/article/41011216162047fba55a7d969f633b9c
Autor:
Patricia R. Pitrez, Luís Estronca, Luís Miguel Monteiro, Guillem Colell, Helena Vazão, Deolinda Santinha, Karim Harhouri, Daniel Thornton, Claire Navarro, Anne-Laure Egesipe, Tânia Carvalho, Rodrigo L. Dos Santos, Nicolas Lévy, James C. Smith, João Pedro de Magalhães, Alessandro Ori, Andreia Bernardo, Annachiara De Sandre-Giovannoli, Xavier Nissan, Anna Rosell, Lino Ferreira
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that
Externí odkaz:
https://doaj.org/article/4ba0b6d9e607460d92755869c0269433
Autor:
Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S. Place, Devaveena Dey, Yue Shen, Geoffrey A. Bocobo, Agustin H. Mohedas, Xiuli Huang, Philip E. Sanderson, Arthur Lee, Wei Zheng, Aris N. Economides, James C. Smith, Paul B. Yu, Alex N. Bullock
Publikováno v:
JCI Insight, Vol 6, Iss 8 (2021)
Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare congenital syndrome in which heterotopic bone is formed in soft tissues owing to dysregulated activity of the bone morphogenetic protein (BMP) receptor ki
Externí odkaz:
https://doaj.org/article/7588ba5cc1df479b9057715913b8a478
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-22 (2019)
Embryonic development produces different cell types in response to a small number of inductive signals. Here, the authors characterise how maternal factors modify chromatin to specify initial competence in Xenopus tropicalis, finding that the pioneer
Externí odkaz:
https://doaj.org/article/19a7d45a59f441d6bd501e207aa0ea14
Autor:
John E. Collins, Richard J. White, Nicole Staudt, Ian M. Sealy, Ian Packham, Neha Wali, Catherine Tudor, Cecilia Mazzeo, Angela Green, Emma Siragher, Edward Ryder, Jacqueline K. White, Irene Papatheodoru, Amy Tang, Anja Füllgrabe, Konstantinos Billis, Stefan H. Geyer, Wolfgang J. Weninger, Antonella Galli, Myriam Hemberger, Derek L. Stemple, Elizabeth Robertson, James C. Smith, Timothy Mohun, David J. Adams, Elisabeth M. Busch-Nentwich
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The transcriptional signature of embryonic lethality has not been defined. Here, the authors, as part of the Deciphering the Mechanisms of Developmental Disorders programme, define genes causing murine embryonic lethality around E9.5 and identify dev
Externí odkaz:
https://doaj.org/article/0cb4c8c4995e4b478eecfb999695d344
Publikováno v:
iScience, Vol 16, Iss , Pp 485-498 (2019)
Summary: One of the earliest and most significant events in embryonic development is zygotic genome activation (ZGA). In several species, bulk transcription begins at the midblastula transition (MBT) when, after a certain number of cleavages, the emb
Externí odkaz:
https://doaj.org/article/9a964442e19840018e9e80d83ad9fa2c
Autor:
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota
Publikováno v:
Wellcome Open Research, Vol 4 (2020)
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively. We have previously
Externí odkaz:
https://doaj.org/article/6d803ddfa9804a42b43f77a667ddecfe
Autor:
Christo P. Christov, Kevin S. Dingwell, Mark Skehel, Helen S. Wilkes, Julian E. Sale, James C. Smith, Torsten Krude
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2265-2278 (2018)
Summary: DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching to Y RNA-dependent initiation at specific origins. Here, we identify xNuRD, an MTA2
Externí odkaz:
https://doaj.org/article/6a015015619d447ca39808fc6098d22e
Autor:
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively. We have previously
Externí odkaz:
https://doaj.org/article/825b99f7ce8c4131b3178e4180dfa8e2
Autor:
Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that thi
Externí odkaz:
https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c