Zobrazeno 1 - 10
of 29
pro vyhledávání: '"James C. Parham"'
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 8:75-83
Chinese hamster cells in culture were used to compare the radiosensitizing efficiency and cytotoxicity of misonidazole with several 2, 4 and 5 substituted nitroimidazoles. The two substituted compounds (SR 2508 and SR 2555) are similar to misonidazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b46a94b038955ad73baf615426c60f
https://doi.org/10.1016/0360-3016(82)90388-1
https://doi.org/10.1016/0360-3016(82)90388-1
Publikováno v:
The Journal of Organic Chemistry. 39:1391-1395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd94b03204081eef0094b3a1c6217f3d
https://doi.org/10.1021/jo00926a015
https://doi.org/10.1021/jo00926a015
Publikováno v:
The Journal of Organic Chemistry. 43:2325-2330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28150fdf1d291a036326b9409caf2427
https://doi.org/10.1021/jo00406a004
https://doi.org/10.1021/jo00406a004
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 8:447-451
Electron affinic compounds, such as misonidazole, preferentially sensitize hypoxic cells to killing by X rays, and are also preferentially cytotoxic to cells deficient in oxygen. Prolonged exposure of cells to misonidazole prior to irradiation result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852e642d16a41df995c9ed79c0cdc4d2
https://doi.org/10.1016/0360-3016(82)90658-7
https://doi.org/10.1016/0360-3016(82)90658-7
Autor:
Mary Agnes Templeton, James C. Parham
Publikováno v:
The Journal of Organic Chemistry. 43:544-550
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c26fe5c2e00d1875779913175f60218f
https://doi.org/10.1021/jo00398a004
https://doi.org/10.1021/jo00398a004
Autor:
James C. Parham, Mary Agnes Templeton
Publikováno v:
Tetrahedron. 36:709-713
UV irradiation of a model “activated ester” of the oncogen 3-hydroxyxanthine induced homolytic cleavage of the N-O bond and gave products arising by reduction of as well as by recombination of the solvent caged amidyl radical intermediate. Identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::583fdb0f10af35f196eb86496a3512a2
https://doi.org/10.1016/s0040-4020(01)93681-6
https://doi.org/10.1016/s0040-4020(01)93681-6
Autor:
Bao-Shan Huang, James C. Parham
Publikováno v:
The Journal of Organic Chemistry. 44:4046-4050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff36e2f5d02ca570e9029703c5915eaf
https://doi.org/10.1021/jo01337a005
https://doi.org/10.1021/jo01337a005
Publikováno v:
Journal of Medicinal Chemistry. 26:283-286
An N-aminated pyrazine analogue of cytidine, in which the pyrimidine N(3) ring nitrogen and C(4) amino group were replaced by a C-amino and an N-amino function, respectively, was prepared as a potential deaminase-resistant cytidine antimetabolite. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07f43efd403ff9f6b5842d10ecf8d3a
https://doi.org/10.1021/jm00356a033
https://doi.org/10.1021/jm00356a033
Autor:
Francis M. Sirotnak, James R. Piper, James C. Parham, D. M. Moccio, Paul L. Chello, John A. Montgomery
Publikováno v:
Biochemical Pharmacology. 29:3293-3298
During studies with L1210 cells and a variety of folate analogs, large discrepancies were revealed between data on membrane transport, on inhibition of dihydrofolate reductase in cell-free extracts, and on inhibition of growth in culture for 10-oxa-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9f8e462a4049ea58ff027b50578447
https://doi.org/10.1016/0006-2952(80)90306-8
https://doi.org/10.1016/0006-2952(80)90306-8
Autor:
Fuk L. Lam, James C. Parham
Publikováno v:
Tetrahedron. 38:2371-2376
UV irradiation of the potent oncogen hypoxanthine 3-oxide in aqueous solution induces elimination of and rearrangement of the nitrogen-bound oxygen. The extent of each reaction shows a complex variation over the pH range 0–7. The variations in quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39be4cf95774716cb34f33c4a67c1046
https://doi.org/10.1016/0040-4020(82)87015-4
https://doi.org/10.1016/0040-4020(82)87015-4