Zobrazeno 1 - 10
of 19
pro vyhledávání: '"James C. McConnell"'
Autor:
Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In breast cancer, dormant cancer cells may develop into bone metastases. Here, the authors demonstrate that microenvironmental IL1β stimulates metastatic breast cancer cell colonisation in the bone via IL1β-NFKB/CREB-Wnt pathway activation and canc
Externí odkaz:
https://doaj.org/article/c9b7748a363e46eb80d945fea7c4be66
Autor:
Adam Nicholas Keen, Andrew J Fenna, James C McConnell, Michael J Sherratt, Peter eGardner, Holly A Shiels
Publikováno v:
Frontiers in Physiology, Vol 6 (2016)
Chronic pressure or volume overload can cause the vertebrate heart to remodel. The hearts of fish remodel in response to seasonal temperature change. Here we focus on the passive properties of the fish heart. Building upon our previous work on therma
Externí odkaz:
https://doaj.org/article/872835b92f174dcda3130ba02e67d794
Autor:
Tamara Griffiths, Poonam Halai, A.K. Langton, Christopher E.M. Griffiths, James C. McConnell, L F Cotterell, Rachel E.B. Watson
Publikováno v:
Langton, A K, Mcconnell, J C, Cotterell, L F, Halai, P, Griffiths, T W, Griffiths, C E M & Watson, R E B 2021, ' Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse, a novel over-the-counter anti-ageing product ', Journal of the European Academy of Dermatology and Venereology . https://doi.org/10.1111/jdv.17612
Chronic sun exposure induces profound changes to the dermal extracellular matrix (ECM) resulting in the loss of fibrillin-rich microfibrils (FRM) [1] and fibrillar collagen [2]. The gold standard topical treatment for photoaged skin is all-trans reti
Publikováno v:
Graham, H, McConnell, J, Limbert, G & Sherratt, M 2019, ' How stiff is skin? ', Experimental Dermatology, vol. 28, no. S1 . https://doi.org/10.1111/exd.13826
The measurement of the mechanical properties of skin (such as stiffness, extensibility and strength) is a key step in characterisation of both dermal ageing and disease mechanisms and in the assessment of tissue-engineered skin replacements. However,
Autor:
Andrew J. Fenna, Peter Gardner, Michael J. Sherratt, James C. McConnell, Holly A. Shiels, Adam N. Keen
Publikováno v:
Keen, A N, Fenna, A J, Mcconnell, J, Sherratt, M, Gardner, P & Shiels, H 2018, ' Macro-and micro-mechanical remodelling in the fish atrium is associated with regulation of collagen 1 alpha 3 chain expression. ', Pflügers Archiv European Journal of Physiology . https://doi.org/10.1007/s00424-018-2140-1
Pflugers Archiv
Pflugers Archiv
Numerous pathologies lead to remodelling of the mammalian ventricle, often associated with fibrosis. Recent work in fish has shown that fibrotic remodelling of the ventricle is ‘reversible’, changing seasonally as temperature-induced changes in b
Autor:
A.J. Bodey, C.M. Disney, Brian K. Bay, Peter D. Lee, Alexander Eckersley, Judith A. Hoyland, James C. McConnell, Hua Geng, Michael J. Sherratt
Publikováno v:
Disney, C M, Eckersley, A, Mcconnell, J C, Geng, H, Bodey, A J, Hoyland, J A, Lee, P D, Sherratt, M J & Bay, B K 2019, ' Synchrotron tomography of intervertebral disc deformation quantified by digital volume correlation reveals microstructural influence on strain patterns ', Acta Biomaterialia . https://doi.org/10.1016/j.actbio.2019.05.021
The intervertebral disc (IVD) has a complex and multiscale extracellular matrix structure which provides unique mechanical properties to withstand physiological loading. Low back pain has been linked to degeneration of the disc but reparative treatme
Autor:
Brian K. Bay, Alexander Eckersley, Hua Geng, Michael J. Sherratt, Judith A. Hoyland, James C. McConnell, Peter D. Lee, A.J. Bodey, C.M. Disney
Publikováno v:
SSRN Electronic Journal.
The intervertebral disc (IVD) has a complex and multiscale extracellular matrix structure which provides unique mechanical properties to withstand physiological loading. Low back pain has been linked to degeneration of the disc but reparative treatme
Autor:
Miles Howe, Eleanor Broadberry, Charles H. Streuli, Qing-Jun Meng, James C. McConnell, Egor Zindy, Nan Yang, Rachel Waddington, Angela Leek, Jack Williams, Leena Dennis Joseph
Publikováno v:
Breast Cancer Research : BCR
Broadberry, E, Mcconnell, J, Williams, J, Yang, N, Zindy, E, Leek, A, Waddington, R, Joseph, L, Howe, M, Meng, Q & Streuli, C H 2018, ' Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours ', Breast Cancer Research, vol. 20, no. 1 . https://doi.org/10.1186/s13058-018-1053-4
Breast cancer research, 20 (1
Breast Cancer Research, Vol 20, Iss 1, Pp 1-13 (2018)
Broadberry, E, Mcconnell, J, Williams, J, Yang, N, Zindy, E, Leek, A, Waddington, R, Joseph, L, Howe, M, Meng, Q & Streuli, C H 2018, ' Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours ', Breast Cancer Research, vol. 20, no. 1 . https://doi.org/10.1186/s13058-018-1053-4
Breast cancer research, 20 (1
Breast Cancer Research, Vol 20, Iss 1, Pp 1-13 (2018)
Background Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism. Circadian disruptions have been proposed as a con
Autor:
Michael J. Sherratt, Rachel E.B. Watson, James C. McConnell, Helen K. Graham, Cem Griffiths, A.K. Langton
Publikováno v:
Langton, A K, Graham, H, McConnell, J C, Sherratt, M J, Griffiths, C E M & Watson, R E B 2017, ' Organisation of the dermal matrix impacts the biomechanical properties of skin ', British Journal of Dermatology, vol. 177, no. 3, pp. 818-827 . https://doi.org/10.1111/bjd.15353
SummaryBackground Human skin has the crucial roles of maintaining homeostasis and protecting against the external environment. Skin offers protection against mechanical trauma due to the reversible deformation of its structure; these biomechanical pr