Zobrazeno 1 - 10
of 45
pro vyhledávání: '"James C. Marsters"'
Autor:
Frederic J. de Sauvage, Ivor Caro, Ervin H. Epstein, James C. Marsters, Lee L. Rubin, Angela Wu, Elana Shpall, Kris S. Chang, Karen Kotkow, Frank Wang, Robert L. Yauch, Ling Fu, Christopher A. Callahan, Mike Reich, Dongwei Li, Jean Y. Tang, Tracy Tang
Supplementary Materials and Methods; Supplementary Tables S1-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5843873f54a17988876092c3b15e71ba
https://doi.org/10.1158/1078-0432.22440850.v1
https://doi.org/10.1158/1078-0432.22440850.v1
Autor:
Frederic J. de Sauvage, Ivor Caro, Ervin H. Epstein, James C. Marsters, Lee L. Rubin, Angela Wu, Elana Shpall, Kris S. Chang, Karen Kotkow, Frank Wang, Robert L. Yauch, Ling Fu, Christopher A. Callahan, Mike Reich, Dongwei Li, Jean Y. Tang, Tracy Tang
Purpose: Inappropriate activation of the Hedgehog (Hh) signaling pathway in skin is critical for the development of basal cell carcinomas (BCC). We have investigated the anti-BCC efficacy of topically-applied CUR61414, an inhibitor of the Hh signal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd72233859bb4f53ad71624a49cc6b3
https://doi.org/10.1158/1078-0432.c.6518113
https://doi.org/10.1158/1078-0432.c.6518113
Autor:
James C. Marsters, Lee L. Rubin, Frank Wang, Dongwei Li, Ervin H. Epstein, Ivor Caro, Jean Y. Tang, Tracy Tang, Ling Fu, Elana Shpall, Frederic J. de Sauvage, Mike Reich Reich, Kris S. Chang, Christopher A. Callahan, Karen Kotkow, Angela Ruoha Wu, Robert L. Yauch
Publikováno v:
Clinical Cancer Research. 17:3378-3387
Purpose: Inappropriate activation of the Hedgehog (Hh) signaling pathway in skin is critical for the development of basal cell carcinomas (BCC). We have investigated the anti-BCC efficacy of topically-applied CUR61414, an inhibitor of the Hh signal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6143dc3467df0a7ea4870935df4f198d
https://doi.org/10.1158/1078-0432.ccr-10-3370
https://doi.org/10.1158/1078-0432.ccr-10-3370
Autor:
Georgette Castanedo, Shirley A. Brunton, Susan Wong, James C. Marsters, Lesley J. Murray, Laurent Salphati, Karen Kotkow, Cyrus Khojasteh, Kevin Lau, Stanley Mark S, Michael F. T. Koehler, Dina Michael S, Lee L. Rubin, Wei Jia, Hank La, Daniel P. Sutherlin, Leslie Lee, Shumei Wang, Jason Halladay, Changgeng Qian, John H. A. Stibbard, Savita Ubhayaker, Janet L. Gunzner, Kirk Robarge, Stephen E. Gould, Oivin Guichert, Minli Xie, Lalonde Rebecca, Richard Goldsmith, Yong Cui, Derek Marshall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5576-5581
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e862c173e6b7fb83ca5bda975f9f516c
https://doi.org/10.1016/j.bmcl.2009.08.049
https://doi.org/10.1016/j.bmcl.2009.08.049
Autor:
Daniel D. Von Hoff, Frederic J. de Sauvage, Josina C. Reddy, Walter C. Darbonne, Howard Mackey, Charles M. Rudin, Jennifer A. Low, Bertram L. Lum, Christine L. Hann, James C. Marsters, Patricia LoRusso, Mitesh J. Borad, Julie R. Brahmer, Robert L. Yauch, Glen J. Weiss, Raoul Tibes
Publikováno v:
New England Journal of Medicine. 361:1164-1172
Background Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a phase 1 clinical trial, we assessed the safety and pharmacokinetics of GDC-0449,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8f96a281bbdefa7032c5fcc17597b8
https://doi.org/10.1056/nejmoa0905360
https://doi.org/10.1056/nejmoa0905360
Publikováno v:
Journal of Molecular Biology. 348:699-709
The diversity of natural antibodies is limited by the genetic mechanisms that engender diversity and the functional requirements of antigen binding. Using an in vitro-evolved autonomous heavy chain variable domain (V(H)H-RIG), we have investigated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822422e6550050b53b31ca35c21c5a6e
https://doi.org/10.1016/j.jmb.2005.02.063
https://doi.org/10.1016/j.jmb.2005.02.063
Autor:
Stanley Mark S, Robert S. McDowell, Maureen Beresini, Ignacio Aliagas-Martin, Daniel J. Burdick, Kevin R Clark, Thomas R. Gadek, James C. Marsters
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2055-2059
o-Bromobenzoyl l-tryptophan 1 inhibits the association of LFA-1 with ICAM-1 with an IC(50) of 1.7microM. Evaluation of the structure-activity relationship of the benzoyl moiety shows that 2,6-di-substitutions greatly enhance potency of this class of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b75d7af000053f084261bfd1b6747a
https://doi.org/10.1016/j.bmcl.2004.02.046
https://doi.org/10.1016/j.bmcl.2004.02.046
Publikováno v:
Journal of Molecular Biology. 332:643-655
Camelids produce functional antibodies devoid of light chains. Autonomous heavy chain variable (V(H)H) domains in these molecules have adapted to the absence of the light chain in the following ways: bulky hydrophobic residues replace small aliphatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edddb69b3e0fbac0ccfdcbff76ff36a
https://doi.org/10.1016/s0022-2836(03)00967-7
https://doi.org/10.1016/s0022-2836(03)00967-7
Autor:
Susan M. Keating, James C. Marsters, Daniel P. Sutherlin, Sherman Fong, Lisa D. Caris, Kevin R Clark, Georgette Castanedo, John B. Nicholas, Henry Chiu, Fredrick C. Sailes, Maureen Beresini, David Y. Jackson, N. Dubree
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2913-2917
Two structural classes of dual α4β1/α4β7 integrin antagonists were investigated via solid-phase parallel synthesis. Using an acylated amino acid backbone, lead compounds containing biphenylalanine or tyrosine carbamate scaffolds were optimized fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3adcb9e0dd0192ba5beec71eb01a0d6
https://doi.org/10.1016/s0960-894x(02)00597-8
https://doi.org/10.1016/s0960-894x(02)00597-8
Autor:
Gregg P. Solar, Ajay K. Malik, Daniel Eric Sherman, Xiao Huan Liang, James C. Marsters, Hans-Peter Gerber, Gloria Meng, Kyu Hong, Napoleone Ferrara
Publikováno v:
Nature. 417:954-958
Vascular endothelial growth factor (VEGF) is a principal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF differentially regulates these processes have been elusive. Here we describe a regulatory loop by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07ab896def39b0d53d754953e70b426
https://doi.org/10.1038/nature00821
https://doi.org/10.1038/nature00821