Zobrazeno 1 - 10
of 396
pro vyhledávání: '"James C. Keith"'
Autor:
Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Steffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, George P. Vlasuk
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 12, Pp 2358-2370 (2009)
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functions but most notably cholesterol homeostasis encompassing cholesterol transport, catabolism, and abso
Externí odkaz:
https://doaj.org/article/ec0b71a6e2bf4790a3a5a3256e00f5d7
Publikováno v:
Critical Care Medicine. 48:735-735
Publikováno v:
Critical Care Medicine. 48:532-532
Autor:
Michael Rosol, James C. Keith, Samantha St. Pierre, Xiaonan Ma, Malachi Sheahan, William P. Newman, Guenevere Rae, Nancy A. Obuchowski, Eric S. Perlman, David S. Paik, Andrew J. Buckler
Purpose To (a) evaluate whether plaque tissue characteristics determined with conventional computed tomographic (CT) angiography could be quantitated at higher levels of accuracy by using image processing algorithms that take characteristics of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb532ea7cb1870d1846bf0d8db4ac6eb
https://europepmc.org/articles/PMC5790306/
https://europepmc.org/articles/PMC5790306/
Autor:
Steve Tam, Qin Wang, Adrian Huang, Desiree H.H. Tsao, Natalia Sushkova, Michael Dennis Lowe, Gray D. Shaw, Patricia W. Bedard, Li Di, Boris Tchernychev, James C. Keith, Neelu Kaila, Robert G. Schaub, Kristin Janz, Valerie Clerin, Alessandro Moretto
Publikováno v:
Journal of Medicinal Chemistry. 53:6003-6017
Previously, we reported the discovery of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor. It is active in a variety of animal models of cardiovascular disease. Compound 1a has also been shown to be well tole
Autor:
Maria Stangou, Ping-Chin Lai, Gurjeet Bhangal, Frederick W.K. Tam, Jennifer A. Smith, James C. Keith, Joseph J. Boyle, Charles D. Pusey, Terence Cook
Publikováno v:
Journal of Nephrology. 24:106-111
BACKGROUND The effect of interleukin-11 (IL-11) on transforming growth factor-s (TGF-s) is controversial and has not been examined in renal diseases. In this study, we (i) characterised the up-regulation of TGF-s1, phospho-p38 MAPK (p-p38 MAPK) and e
Autor:
Leo M. Albert, James C. Keith, Kathleen M. Shields, Vasu Maganti, George P. Vlasuk, Jeffrey L. Feldman, Gustave T. Hebert, Debra D. Pittman, Heather H. Shih, Anthony Wong, Janet E. Paulsen, Aaron Winkler, Christine Resmini, Valerie Clerin, Nanhua Deng
Publikováno v:
Atherosclerosis. 201:53-66
Objective The present study was conducted to characterize the expression of the cysteine protease legumain in murine and human atherosclerotic tissues, and to explore the molecular mechanisms by which legumain may contribute to the pathophysiology of
Autor:
Robert G. Schaub, Valerie Clerin, David L. Crandall, Gray D. Shaw, Thomas M. Antrilli, Natalia Sushkova, Laura L. Carter, Christine Resmini, Patricia W. Bedard, Kristin Janz, James K. Hennan, Silvano DeBernardo, James C. Keith, Neelu Kaila, Qin Wang, Boris Tchernychev
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:497-506
P-selectin plays a significant and well documented role in vascular disease by mediating leukocyte and platelet rolling and adhesion. This study characterizes the in vitro activity, pharmacokinetic properties, and the anti-inflammatory and antithromb
Autor:
Raymond T. Camphausen, Cheryl Nickerson-Nutter, Desiree H.H. Tsao, Neelu Kaila, Adam D. Shilling, Ruth Young-Sciame, Silvano DeBernardo, Patricia W. Bedard, Kristin Janz, Qin Wang, Tam Steve Yik-Kai, James C. Keith
Publikováno v:
Journal of Medicinal Chemistry. 50:21-39
Leukocyte recruitment of sites of inflammation and tissue injury involves leukocyte rolling along the endothelial wall, followed by firm adherence of the leukocyte, and finally transmigration of the leukocyte across cell junctions into the underlying
Autor:
Richard Eric Mewshaw, James C. Keith, Eric S. Manas, Cuijian Yang, Ruth A. Henderson, Heather A. Harris, Richard James Edsall, Zhang B. Xu
Publikováno v:
Journal of Medicinal Chemistry. 48:3953-3979
The 2-phenylnaphthalene scaffold was explored as a simplified version of genistein in order to identify ER selective ligands. With the aid of docking studies, positions 1, 4, and 8 of the 2-phenylnaphthalene template were predicted to be the most pot