Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James C. Jiang"'
Autor:
Srinivas eAyyadevara, Cagdas eTazearslan, Ramani eAlla, James C Jiang, S Michal Jazwinski, Robert Joseph Shmookler Reis
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
A quantitative trait locus (QTL) in the nematode C. elegans, lsq4, was recently implicated by mapping longevity genes. QTLs for lifespan and 3 stress-resistance traits coincided within a span of
Externí odkaz:
https://doaj.org/article/00abac1825fa48e8985c4b58aea9a9d0
Autor:
Michael V Miceli, James C Jiang, Anurag eTiwari, Jose F Rodriguez-Quiñones, S. Michal eJazwinski
Publikováno v:
Frontiers in Genetics, Vol 2 (2012)
In the budding yeast Sacchoromyces cerevisiae, loss of mitochondrial DNA (rho0) can induce the retrograde response under appropriate conditions, resulting in increased replicative lifespan (RLS). Although the retrograde pathway has been extensively e
Externí odkaz:
https://doaj.org/article/d31a2d7de95f41f9bca78fca5b7eeeb9
Publikováno v:
Biogerontology. 20:93-107
The replicative lifespan of the yeast Saccharomyces cerevisiae models the aging of stem cells. Age asymmetry between the mother and daughter cells is established during each cell division, such that the daughter retains the capacity for self-renewal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::939458e42fce0a6ee0a456f30afa4d96
https://doi.org/10.1007/s10522-018-9779-z
https://doi.org/10.1007/s10522-018-9779-z
Publikováno v:
Genes & Development. 29:1188-1201
“Chromosome kissing” refers to protein-mediated and physiologically relevant interactions between two sites located on either different chromosomes or the same chromosome. Intrachromosomal kissing interactions are also called chromosome looping (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cd5fb5bfde6facd7abb45c91d0c27e
https://doi.org/10.1101/gad.260844.115
https://doi.org/10.1101/gad.260844.115
Autor:
Jose F. Rodriguez-Quiñones, Stefan W. Stumpferl, Qian Qin, S. Michal Jazwinski, James C. Jiang, Anurag Tiwari
Publikováno v:
Genetics. 204(2)
The retrograde response signals mitochondrial status to the nucleus, compensating for accumulating mitochondrial dysfunction during Saccharomyces cerevisiae aging and extending replicative lifespan. The histone acetylase Gcn5 is required for activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381bca64d8f0714737393277c8a3de6d
https://pubmed.ncbi.nlm.nih.gov/27474729
https://pubmed.ncbi.nlm.nih.gov/27474729
Autor:
Jae-Gu Seo, Boguslawa Korona, Jianliang Dai, Anurag Tiwari, James C. Jiang, Stefan W. Stumpferl, Sue E. Brand, S. Michal Jazwinski
Publikováno v:
Genome Research. 22:1963-1973
The genetics of aging in the yeast Saccharomyces cerevisiae has involved the manipulation of individual genes in laboratory strains. We have instituted a quantitative genetic analysis of the yeast replicative lifespan by sampling the natural genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ede7008edb91c9716513812e673830f
https://doi.org/10.1101/gr.136549.111
https://doi.org/10.1101/gr.136549.111
Autor:
Juliana M. Figueiredo, S. Michal Jazwinski, Norton Heise, Carolina M. Koeller, Deivid C. Rodrigues, James C. Jiang, Lucia Mendonça-Previato, Rafael Cardoso Maciel Costa Silva, José O. Previato, Turán P. Ürményi
Publikováno v:
Molecular and Biochemical Parasitology. 182:62-74
In this study, we characterized ceramide synthase (CerS) of the protozoan parasite Trypanosoma cruzi at the molecular and functional levels. TcCerS activity was detected initially in a cell-free system using the microsomal fraction of epimastigote fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1a5ff025a27401b50b4598edb304b6
https://doi.org/10.1016/j.molbiopara.2011.12.006
https://doi.org/10.1016/j.molbiopara.2011.12.006
Autor:
Jacek Bielawski, S. Michal Jazwinski, Rashna Bhandari, Solomon H. Snyder, Nathan L. Alderson, Besim Ogretmen, James C. Jiang, Hiroko Hama, Suriyan Ponnusamy
Publikováno v:
Journal of Biological Chemistry. 283:27514-27524
In this study, we investigated the roles of very long-chain fatty acid (VLCFA) synthesis by fatty acid elongase 3 (ELO3) in the regulation of telomere length and life span in the yeast Saccharomyces cerevisiae. Loss of VLCFA synthesis via deletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66968cb849d1d9facc8a59002737e661
https://doi.org/10.1074/jbc.m802980200
https://doi.org/10.1074/jbc.m802980200
Autor:
Jae-Gu Seo, Fernando Alvarez-Vasquez, Stefka D. Spassieva, James C. Jiang, S. Michal Jazwinski, Yusuf A. Hannun, Lina M. Obeid, Jacek Bielawski
Publikováno v:
Journal of Biological Chemistry. 281:33931-33938
Lag1 (longevity assurance gene 1) homologues, a family of transmembrane proteins found in all eukaryotes, have been shown to be necessary for (dihydro)ceramide synthesis. All Lag1 homologues contain a highly conserved stretch of 52 amino acids known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd6cbf81a3347d0d0ecdb16c3f5bbd0
https://doi.org/10.1074/jbc.m608092200
https://doi.org/10.1074/jbc.m608092200
Publikováno v:
Experimental Gerontology. 39:999-1009
Individual yeast cells display a finite replicative capacity. LAG1 was identified as a gene that is differentially expressed during the yeast replicative life span and was shown to play a role in determining yeast longevity. This gene is not essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc29c52bc0b4f7eb6c775c75cd7e329
https://doi.org/10.1016/j.exger.2004.03.026
https://doi.org/10.1016/j.exger.2004.03.026