Zobrazeno 1 - 10
of 78
pro vyhledávání: '"James C. Gilbert"'
Autor:
Katarina D. Kovacevic, Stefan Greisenegger, Agnes Langer, Georg Gelbenegger, Nina Buchtele, Ingrid Pabinger, Karin Petroczi, Shuhao Zhu, James C. Gilbert, Bernd Jilma
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The effect of conventional anti-platelet agents is limited in secondary stroke prevention, and their effects are blunted under high shear stress in the presence of increased levels of circulating von Willebrand factor (VWF). VWF is criticall
Externí odkaz:
https://doaj.org/article/9dfb1cccbadd4e0893278bc3fc62d9a6
Autor:
Katarina D. Kovacevic, Jürgen Grafeneder, Christian Schörgenhofer, Georg Gelbenegger, Gloria Gager, Christa Firbas, Peter Quehenberger, Petra Jilma-Stohlawetz, Andrea Bileck, Shuhao Zhu, James C. Gilbert, Martin Beliveau, Bernd Jilma, Ulla Derhaschnig
Publikováno v:
Haematologica, Vol 107, Iss 9 (2021)
Von Willebrand factor (VWF) and factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary hemostasis and clotting, respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and
Externí odkaz:
https://doaj.org/article/e56807657eb34193873de3efd70e7f5d
Publikováno v:
Journal of Pediatric Surgery Case Reports, Vol 29, Iss C, Pp 14-17 (2018)
Post-pyloromyotomy emesis is common and may be secondary to non-surgical conditions such as pyloric edema, gastroparesis, pylorospasm, or gastroesophageal reflux. Early persistent postoperative emesis is typically attributed to an incomplete pyloromy
Externí odkaz:
https://doaj.org/article/8470cc9699e84cf491cc04edca18a385
Autor:
Cihan Ay, Katarina D. Kovacevic, Daniel Kraemmer, Christian Schoergenhofer, Georg Gelbenegger, Christa Firbas, Peter Quehenberger, Petra Jilma-Stohlawetz, James C. Gilbert, Shuhao Zhu, Martin Beliveau, Franz Koenig, Alfonso Iorio, Bernd Jilma, Ulla Derhaschnig, Ingrid Pabinger
Publikováno v:
Blood. 141:1147-1158
Factor VIII (FVIII) circulates in a noncovalent complex with von Willebrand Factor (VWF), the latter determining FVIII half-life. The VWF-binding aptamer rondaptivon pegol (BT200) increases plasma levels of VWF/FVIII in healthy volunteers. This trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5617c9a930162219151c717b91a41e89
https://doi.org/10.1182/blood.2022016571
https://doi.org/10.1182/blood.2022016571
Autor:
Cihan Ay, Ingrid Pabinger, Katarina D. Kovacevic, Georg Gelbenegger, Christian Schörgenhofer, Peter Quehenberger, Petra Jilma-Stohlawetz, Raute Sunder-Plassman, James C. Gilbert, Shuhao Zhu, Bernd Jilma, Ulla Derhaschnig
Publikováno v:
Blood Advances. 6:5467-5476
Type 2B von Willebrand disease (VWD) is characterized by an increased binding affinity of von Willebrand factor (VWF) to platelet glycoprotein Ib. This can lead to clearance of high-molecular-weight (HMW) multimers and thrombocytopenia with a resulti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6641a45a311c4f411699ff4af7c525
https://doi.org/10.1182/bloodadvances.2022007805
https://doi.org/10.1182/bloodadvances.2022007805
Autor:
Bernd Jilma, Gloria M. Gager, Georg Gelbenegger, Andrea Bileck, Christa Firbas, Peter Quehenberger, Ulla Derhaschnig, Petra Jilma-Stohlawetz, Jürgen Grafeneder, Katarina D. Kovacevic, Shuhao Zhu, James C. Gilbert, Christian Schörgenhofer, Martin Beliveau
Publikováno v:
Haematologica. 107:2121-2132
Von Willebrand factor (VWF) and factor VIII (FVIII) circulate in a noncovalent complex in blood and promote primary hemostasis and clotting, respectively. A new VWF A1-domain binding aptamer, BT200, demonstrated good subcutaneous bioavailability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a3103db66def9c3d150775f7b52d11
https://doi.org/10.3324/haematol.2021.279948
https://doi.org/10.3324/haematol.2021.279948
Autor:
Daiwu Kang, Zicai Liang, Bernd Jilma, James C. Gilbert, Shuhao Zhu, Ming Li, Paul M. Tarantino
Publikováno v:
Journal of Thrombosis and Haemostasis
Background BT200, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis in cynomolgus monkeys. It is being developed for secondary prevention of arterial t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8591b90ce66f6f1c94ef7afc171d17ff
https://doi.org/10.1111/jth.14822
https://doi.org/10.1111/jth.14822
Autor:
Shan Gao, James C. Gilbert, Daiwu Kang, Warren Harvey, Shuhao Zhu, Zicai Liang, Bernd Jilma, Paul Hatala
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Thrombus formation involves coagulation proteins and platelets. The latter, referred to as platelet-mediated thrombogenesis, is predominant in arterial circulation. Platelet thrombogenesis follows vascular injury when extracellular von Wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b617843b93e57b2fa268235be014d10
https://doi.org/10.1111/jth.14755
https://doi.org/10.1111/jth.14755
Publikováno v:
Journal of Pediatric Surgery Case Reports, Vol 60, Iss, Pp 101528-(2020)
DiGeorge Syndrome is a collection of symptoms stemming from a heterozygous microdeletion on chromosome 22. An eleven-year-old girl with DiGeorge syndrome presented to our Pediatric Surgery with a history of episodes of vomiting since birth, and a rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cc9dffa15ae1b3c19c3770814a6b83
http://www.sciencedirect.com/science/article/pii/S2213576620301627
http://www.sciencedirect.com/science/article/pii/S2213576620301627
Autor:
Christian Hengstenberg, Katarina D. Kovacevic, Max-Paul Winter, Irene Lang, Aurel Toma, Jacek Kubica, Jolanta M. Siller-Matula, Shuhao Zhu, Bernd Jilma, James C. Gilbert
Publikováno v:
Thrombosis and haemostasis. 120(9)
Background von Willebrand factor (VWF) is crucial for arterial thrombosis and its plasma levels are increased in acute coronary syndromes (ACSs). The effects of conventional platelet inhibitors are compromised by elevated VWF under high shear rates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5404ac3188b329193b2bc0a3c0800a
https://pubmed.ncbi.nlm.nih.gov/32679592
https://pubmed.ncbi.nlm.nih.gov/32679592