Výsledky vyhledávání - "James C. Felli"

A Bayesian approach to toxicological testing

Autor: James C. Felli, Derek J. Leishman

Publikováno v: Journal of Pharmacological and Toxicological Methods. 105:106898

Introduction Testing for toxicities is an important activity in drug development. In an ideal world the tests applied would be definitive. In reality this is seldom the case. There are two types of power associated with a test. A test's discriminator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7358250b1040524e00a09bddb7d2f226
https://doi.org/10.1016/j.vascn.2020.106898

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Real estate diagrams: A tool to quickly assess the utility of a new predictive technology

Autor: James C. Felli, Derek J. Leishman

Publikováno v: Journal of pharmacological and toxicological methods. 99

Introduction Scientists are increasingly in a position to ask whether or not to adopt new technologies. We present a visualization tool to help scientists swiftly evaluate the worth of new assays. Methods The parameters (prevalence, sensitivity and,

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https://pubmed.ncbi.nlm.nih.gov/31247306

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Possibility Engineering

Autor: James C. Felli

Publikováno v: Decision Analysis. 12:61-73

Possibility engineering is a variant of decision analysis that focuses on highlighting a robust set of acceptable courses of action that satisfy a decision maker’s value constraints rather than identifying and prescribing a single, optimal course o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60b113bde9ef3cbde6567379210f077b
https://doi.org/10.1287/deca.2014.0309

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A semi-Markov model for patient progression through clinical trials

Autor: James P. Kremidas, Wesley H. Anderson, Stephen J. Ruberg, James C. Felli

Publikováno v: European Journal of Operational Research. 176:542-549

Clinical trials constitute large, resource-intensive endeavors for pharmaceutical companies, academic institutions and government agencies. Accounts have estimated the number of patients involved in clinical trials in the US as high as 725,000 patien

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https://doi.org/10.1016/j.ejor.2005.08.003

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Javelin Diagrams: A Graphical Tool for Probabilistic Sensitivity Analysis

Autor: Gordon B. Hazen, James C. Felli

Publikováno v: Decision Analysis. 1:93-107

To demonstrate post hoc robustness of decision problems to parameter estimates, analysts may conduct a probabilistic sensitivity analysis, assigning distributions to uncertain parameters and computing the probability of decision change. In contrast t

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https://doi.org/10.1287/deca.1030.0006

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Discounting Effectiveness

Autor: Kent D. Wall, James C. Felli

Publikováno v: Military Operations Research. 8:5-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e6d92e67611946b7a7bd2f94c76b8d6
https://doi.org/10.5711/morj.8.4.5

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Foreign exchange and lost opportunity in the US Department of Defense

Autor: James C. Felli, Gerald M. Groshek

Publikováno v: Journal of Multinational Financial Management. 10:73-89

This paper examines US Department of Defense (DoD) foreign exchange rate exposure in light of the government’s prohibition against foreign currency hedging. Using data from the United States Air Force and Monte Carlo simulation, we evaluate whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8335c56c3d1ba0d639c5daed79535af8
https://doi.org/10.1016/s1042-444x(99)00020-1

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Do sensitivity analyses really capture problem sensitivity? An empirical analysis based on information value

Autor: James C. Felli, Gordon B. Hazen

Publikováno v: Risk Decision and Policy. 4:79-98

The most common methods of sensitivity analysis (SA) in decision-analytic modeling are based either on proximity in parameter-space to decision thresholds or on the range of payoffs that accompany parameter variation. As an alternative, we propose th

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https://doi.org/10.1080/135753099348003

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Benefit-Risk Assessment in Pharmaceutical Research and Development

Autor: Rebecca Noel, James C. Felli, Andreas Sashegyi

Early Clinical Development Pharmaceutical Benefit-Risk Assessment in Early Development Bennett Levitan and James Cross Full Clinical Development Key Questions, Issues, and Challenges in Benefit-Risk Assessment in Full Clinical Development John Fergus

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https://doi.org/10.1201/b16070

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R&D Risk Management

Autor: John S. Andersen, James C. Felli

Publikováno v: Wiley Encyclopedia of Operations Research and Management Science

Risk is a major concern in functional R&D organizations, and can arise from any number of sources from simple misunderstandings to natural disasters. Yet despite its importance and prevalence, risk is typically loosely described and poorly characteri

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https://doi.org/10.1002/9780470400531.eorms0703

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