Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James C. Comolli"'
Autor:
Rachelle Prantil-Baun, Jonathan R. Coppeta, T J Mulhern, James C. Comolli, Ernest S. Kim, Brett C. Isenberg, Jeffrey T. Borenstein, Abigail June Spencer, Amanda R. Lever, Mark J. Mescher
Publikováno v:
Lab on a Chip. 17:134-144
The drug development pipeline is severely limited by a lack of reliable tools for prediction of human clinical safety and efficacy profiles for compounds at the pre-clinical stage. Here we present the design and implementation of a platform technolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c341a71358546bdf14cfc6077f211cf
https://doi.org/10.1039/c6lc01236a
https://doi.org/10.1039/c6lc01236a
Autor:
Joseph Ashour, Kim L. Weirich, Karthik Viswanathan, Jennifer P. Wang, Zachary Shriver, Gabriel L. Hendricks, Deborah Kuchnir Fygenson, Hidde L. Ploegh, Evelyn A. Kurt-Jones, Jing Li, James C. Comolli, Robert W. Finberg
Publikováno v:
Journal of Biological Chemistry. 288:8061-8073
Influenza is a severe disease in humans and animals with few effective therapies available. All strains of influenza virus are prone to developing drug resistance due to the high mutation rate in the viral genome. A therapeutic agent that targets a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d513e4b693039353656c9c8699066249
https://doi.org/10.1074/jbc.m112.437202
https://doi.org/10.1074/jbc.m112.437202
Autor:
Scott A. Beatson, Jacob J. Bertrand, Joyce T. West, Pil Jung Kang, Jennifer L Sargent, Joanne N. Engel, Mikkel Klausen, Leslie L. Waite, Tim Tolker-Nielsen, James C. Comolli, Thania Jakobsen, Cynthia B. Whitchurch, John S. Mattick
Publikováno v:
Molecular Microbiology. 55:1357-1378
Virulence of Pseudomonas aeruginosa involves the co-ordinate expression of a range of factors including type IV pili (tfp), the type III secretion system (TTSS) and quorum sensing. Tfp are required for twitching motility, efficient biofilm formation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::200dcdb38beca2323a6077a3500551c9
https://doi.org/10.1111/j.1365-2958.2005.04479.x
https://doi.org/10.1111/j.1365-2958.2005.04479.x
Autor:
James C. Comolli, Timothy J. Donohue
Publikováno v:
Molecular Microbiology. 51:1193-1203
Summary Bacterial cytochrome cbb 3 oxidases are members of the haeme-copper oxidase superfamily that are important for energy conservation by a variety of pro- teobacteria under oxygen-limiting conditions. The opportunistic pathogen Pseudomonas aerug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::099bf5019d98604efc4fc7c784ac8de8
https://doi.org/10.1046/j.1365-2958.2003.03904.x
https://doi.org/10.1046/j.1365-2958.2003.03904.x
Autor:
Timothy J. Donohue, James C. Comolli
Publikováno v:
Molecular Microbiology. 45:755-768
The facultative anaerobe Pseudomonas aeruginosa has multiple aerobic electron transport pathways, one of which is terminated by a cyanide-insensitive oxidase (CIO). This study characterizes a P. aeruginosa two-component system that regulates CIO prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6571fc0c508b0c99003d8d901af8abdc
https://doi.org/10.1046/j.1365-2958.2002.03046.x
https://doi.org/10.1046/j.1365-2958.2002.03046.x
Publikováno v:
Journal of Bacteriology. 184:390-399
Anoxygenic photosynthetic growth of Rhodobacter sphaeroides , a member of the α subclass of the class Proteobacteria , requires the response regulator PrrA. PrrA and the sensor kinase PrrB are part of a two-component signaling pathway that influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1278736c06998b7b7111cdbd9b5b2d9b
https://doi.org/10.1128/jb.184.2.390-399.2002
https://doi.org/10.1128/jb.184.2.390-399.2002
Autor:
Zachary Shriver, David M. Knipe, Natasha Qaisar, Robert W. Finberg, Karthik Viswanathan, Jennifer P. Wang, James C. Delaney, Deborah Kuchnir Fygenson, Jose M. Trevejo, Gabriel L. Hendricks, Serena T. Pham, Leila N. Albers, James C. Comolli, Evelyn A. Kurt-Jones, Lourdes Velazquez
Publikováno v:
Antiviral research. 116
Heparan sulfate (HS) is a ubiquitous glycosaminoglycan that serves as a cellular attachment site for a number of significant human pathogens, including respiratory syncytial virus (RSV), human parainfluenza virus 3 (hPIV3), and herpes simplex virus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863979224a1651e6bab9aae6dde968a5
https://pubmed.ncbi.nlm.nih.gov/25637710
https://pubmed.ncbi.nlm.nih.gov/25637710
Autor:
Francisco M. Marty, Margaret M. Shea, Lindsey R. Baden, Sean M. Fortier, James C. Comolli, Horatio R. Thomas, Robert C. Lynch, Sophia Koo, Preshious Rearden, S. David Daniels
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 59(12)
Background. Invasive aspergillosis (IA) remains a leading cause of mortality in immunocompromised patients, in part due to the difficulty of diagnosing this infection. Methods. Using thermal desorption-gas chromatography/mass spectrometry, we charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acd71ae531bbb0f01bccb3f04ba23d1
https://pubmed.ncbi.nlm.nih.gov/25342502
https://pubmed.ncbi.nlm.nih.gov/25342502
Autor:
Joanne N. Engel, R. Kowal, Lynne Garrity-Ryan, Alan R. Hauser, James C. Comolli, B. I. Kazmierczak
Publikováno v:
Infection and Immunity. 68:7100-7113
Pseudomonas aeruginosa, an important nosocomial pathogen of humans, expresses a type III secretion system that is required for virulence. Previous studies demonstrated that the lung-virulent strain PA103 has the capacity to be either cytotoxic or inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffa3ebbb4bfac8c055fcfb7ebb9077f
https://doi.org/10.1128/iai.68.12.7100-7113.2000
https://doi.org/10.1128/iai.68.12.7100-7113.2000
Autor:
Rachelle Prantil-Baun, Jeffrey T. Borenstein, T J Mulhern, James C. Comolli, Amanda R. Lever, Patrick Hayden, George R. Jackson, Hyoungshin Park
Publikováno v:
Physiological Reports
Respiratory viruses invade the upper airway of the lung, triggering a potent immune response that often exacerbates preexisting conditions such as asthma and COPD. Poly(I:C) is a synthetic analog of viral dsRNA that induces the characteristic inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36e9b529323c24263a21a831839f473
https://doi.org/10.14814/phy2.12334
https://doi.org/10.14814/phy2.12334