Zobrazeno 1 - 10
of 37
pro vyhledávání: '"James C Y Dunn"'
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274612 (2022)
BackgroundShort bowel syndrome and its resultant nutritional deficiencies are the most common cause of intestinal failure. Significant intestinal lengthening using intraluminal springs is feasible in porcine models using an external plication techniq
Externí odkaz:
https://doaj.org/article/acc86a34f90b418c9a7d2e69b092923c
Autor:
Hassan A Khalil, Sung Noh Hong, Joshua D Rouch, Andrew Scott, Yonghoon Cho, Jiafang Wang, Michael S Lewis, Martin G Martin, James C Y Dunn, Matthias G Stelzner
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216326 (2019)
Adult intestinal epithelial stem cells are a promising resource for treatment of intestinal epithelial disorders that cause intestinal failure and for intestinal tissue engineering. We developed two different animal models to study the implantation o
Externí odkaz:
https://doaj.org/article/ac6c46814b91499badfbdc8669937872
Autor:
Qianqian Wang, Ke Wang, R Sergio Solorzano-Vargas, Po-Yu Lin, Christopher M Walthers, Anne-Laure Thomas, Martín G Martín, James C Y Dunn
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0195315 (2018)
Although critical for studies of gut motility and intestinal regeneration, the in vitro culture of intestinal muscularis with peristaltic function remains a significant challenge. Periodic contractions of intestinal muscularis result from the coordin
Externí odkaz:
https://doaj.org/article/3035547c8dcc4a8d9a7fe06dbcc03d3d
Autor:
Nhan Huynh, Genia Dubrovsky, Joshua D Rouch, Andrew Scott, Elvin Chiang, Tommy Nguyen, Benjamin M Wu, Shant Shekherdimian, Thomas M Krummel, James C Y Dunn
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200529 (2018)
Spring-mediated distraction enterogenesis has been studied as a novel treatment for short bowel syndrome (SBS). Previous approaches are limited by multiple surgeries to restore intestinal continuity. Purely endoluminal devices require a period of int
Externí odkaz:
https://doaj.org/article/496afad98f804071bb513104a9d4e99b
Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids.
Autor:
Joshua D Rouch, Andrew Scott, Nan Ye Lei, R Sergio Solorzano-Vargas, Jiafang Wang, Elaine M Hanson, Masae Kobayashi, Michael Lewis, Matthias G Stelzner, James C Y Dunn, Lars Eckmann, Martín G Martín
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0148216 (2016)
BACKGROUND & AIMS:Intestinal microfold (M) cells are specialized epithelial cells that act as gatekeepers of luminal antigens in the intestinal tract. They play a critical role in the intestinal mucosal immune response through transport of viruses, b
Externí odkaz:
https://doaj.org/article/07d8f5cad876469394a0a3f303e6097e
Autor:
Hassan A Khalil, Nan Ye Lei, Wenxian Nie, Michael S Lewis, Matthias G Stelzner, Martín G Martín, James C Y Dunn, James Yoo
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127258 (2015)
The myofibroblast is an important stromal cell of the gastrointestinal tract. Current in vitro and in vivo models either do not accurately recreate stromal-epithelial interactions or are not specific to myofibroblasts. We sought to create an animal m
Externí odkaz:
https://doaj.org/article/6412448df3d54bc5801e2d39071dd27f
Autor:
Nan Ye Lei, Ziyad Jabaji, Jiafang Wang, Vaidehi S Joshi, Garrett J Brinkley, Hassan Khalil, Fengchao Wang, Artur Jaroszewicz, Matteo Pellegrini, Linheng Li, Michael Lewis, Matthias Stelzner, James C Y Dunn, Martín G Martín
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84651 (2014)
Intestinal epithelial stem cells (ISCs) are the focus of recent intense study. Current in vitro models rely on supplementation with the Wnt agonist R-spondin1 to support robust growth, ISC self-renewal, and differentiation. Intestinal subepithelial m
Externí odkaz:
https://doaj.org/article/2eafb19bbe58498395971442cc53b9f9
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114850 (2014)
Functionally contracting smooth muscle is an essential part of the engineered intestine that has not been replicated in vitro. The purpose of this study is to produce contracting smooth muscle in culture by maintaining the native smooth muscle organi
Externí odkaz:
https://doaj.org/article/9268e5b1079a4f80b8fc311f79769d5b
Autor:
Ziyad Jabaji, Garrett J Brinkley, Hassan A Khalil, Connie M Sears, Nan Ye Lei, Michael Lewis, Matthias Stelzner, Martín G Martín, James C Y Dunn
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107814 (2014)
BACKGROUND:We previously reported in vitro maintenance and proliferation of human small intestinal epithelium using Matrigel, a proprietary basement membrane product. There are concerns over the applicability of Matrigel-based methods for future huma
Externí odkaz:
https://doaj.org/article/779ce25d251b4da1a717cce68e2bc446
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 2, Pp 41-52 (2024)
Abstract The intestinal epithelium is a dynamic barrier that allows the selective exchange of ions, hormones, proteins, and nutrients. To accomplish this, the intestinal epithelium adopts a highly columnar morphology which is partially lost in submer
Externí odkaz:
https://doaj.org/article/8b32df81a0144b7eafdc48d9e88092bb