Zobrazeno 1 - 10
of 76
pro vyhledávání: '"James C W Locke"'
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 3, Pp n/a-n/a (2022)
Abstract Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day‐night cycle. Mathematical models of the clock are typically either “whole‐plant” that ignore tissue or cell type‐specif
Externí odkaz:
https://doaj.org/article/beee693c15184f40b28fa8312cadb051
Autor:
Christian P Schwall, Torkel E Loman, Bruno M C Martins, Sandra Cortijo, Casandra Villava, Vassili Kusmartsev, Toby Livesey, Teresa Saez, James C W Locke
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 7, Pp n/a-n/a (2021)
Abstract Genetically identical individuals in bacterial populations can display significant phenotypic variability. This variability can be functional, for example by allowing a fraction of stress prepared cells to survive an otherwise lethal stress.
Externí odkaz:
https://doaj.org/article/69c0b08003614400b39971bb6826f28a
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000407 (2019)
Individual plant cells have a genetic circuit, the circadian clock, that times key processes to the day-night cycle. These clocks are aligned to the day-night cycle by multiple environmental signals that vary across the plant. How does the plant inte
Externí odkaz:
https://doaj.org/article/74c422e2cda8434899105a1e62862930
Autor:
Heather M Meyer, José Teles, Pau Formosa-Jordan, Yassin Refahi, Rita San-Bento, Gwyneth Ingram, Henrik Jönsson, James C W Locke, Adrienne H K Roeder
Publikováno v:
eLife, Vol 6 (2017)
Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we s
Externí odkaz:
https://doaj.org/article/89a8d3b5eb77485cac7874e5480dbb50
Autor:
Paul K. Grant, Gregory Szep, Om Patange, Jacob Halatek, Valerie Coppard, Attila Csikász-Nagy, Jim Haseloff, James C. W. Locke, Neil Dalchau, Andrew Phillips
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Morphogen gradients can be dynamic and transient yet give rise to stable cellular patterns. Here the authors show that a synthetic morphogen-induced mutual inhibition circuit produces stable boundaries when the spatial average of morphogens falls wit
Externí odkaz:
https://doaj.org/article/16fc968713644a57910ee1bc73fd0b96
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically identical population of cells. Here, the authors show that stochastic pulsing in the expression of a sigma factor enables the formation of spatial patterns in a
Externí odkaz:
https://doaj.org/article/6aa272885b94430e8fb8948867d55070
Autor:
Om Patange, Christian Schwall, Matt Jones, Casandra Villava, Douglas A. Griffith, Andrew Phillips, James C. W. Locke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Noisy gene expression leading to phenotypic variability can help organisms to survive in changing environments. Here, Patange et al. show that noisy expression of a stress response regulator, RpoS, allows E. coli cells to modulate their growth rates
Externí odkaz:
https://doaj.org/article/9e91aadcaffe440b96bf4b0df8cd6cb8
Publikováno v:
Plant Physiology. 190:938-951
Like many organisms, plants have evolved a genetic network, the circadian clock, to coordinate processes with day/night cycles. In plants, the clock is a pervasive regulator of development and modulates many aspects of physiology. Clock-regulated pro
Autor:
James C. W. Locke, Mark Greenwood
Publikováno v:
Current Opinion in Plant Biology. 53:65-72
The circadian clock is a genetic circuit that allows organisms to anticipate daily events caused by the rotation of the Earth. The plant clock regulates physiology at multiple scales, from cell division to ecosystem-scale interactions. It is becoming
Autor:
Noga Mosheiff, Bruno M. C. Martins, Sivan Pearl-Mizrahi, Alexander Grünberger, Stefan Helfrich, Irina Mihalcescu, Dietrich Kohlheyer, James C. W. Locke, Leon Glass, Nathalie Q. Balaban
Publikováno v:
Physical Review X, Vol 8, Iss 2, p 021035 (2018)
Periodic forcing of nonlinear oscillators leads to a large number of dynamic behaviors. The coupling of the cell cycle to the circadian clock provides a biological realization of such forcing. A previous model of forcing leads to nontrivial relations
Externí odkaz:
https://doaj.org/article/cd823f4190fa4f9eba70cc4d098a45f4