Zobrazeno 1 - 10
of 193
pro vyhledávání: '"James C Mulloy"'
Autor:
Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Inosine monophosphate dehydrogenase (IMPDH) is a rate‐limiting enzyme in de novo guanine nucleotide synthesis pathway. Although IMPDH inhibitors are widely used as effective immunosuppressants, their antitumor effects have not been proven
Externí odkaz:
https://doaj.org/article/80b4174013704cb29ecfb11251a79951
Autor:
Mark Wunderlich, Nicole Manning, Christina Sexton, Anthony Sabulski, Luke Byerly, Eric O'Brien, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225532 (2019)
We have previously characterized an acute myeloid leukemia (AML) chemotherapy model for SCID-based immune deficient mice (NSG and NSGS), consisting of 5 days of cytarabine (AraC) and 3 days of anthracycline (doxorubicin), to simulate the standard 7+3
Externí odkaz:
https://doaj.org/article/cd47170d50ec4a2e8bcc41f4eec1940c
Autor:
Mark Wunderlich, Fu-Sheng Chou, Christina Sexton, Pietro Presicce, Claire A Chougnet, Julio Aliberti, James C Mulloy
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209034 (2018)
Genetic manipulation of NOD/SCID (NS) mice has yielded numerous sub-strains with specific traits useful for the study of human hematopoietic xenografts, each with unique characteristics. Here, we have compared the engraftment and output of umbilical
Externí odkaz:
https://doaj.org/article/a52317cbdd524df4899af7800f53722c
Autor:
Sara Alvarez, Javier Suela, Ana Valencia, Agustín Fernández, Mark Wunderlich, Xabier Agirre, Felipe Prósper, José Ignacio Martín-Subero, Alba Maiques, Francesco Acquadro, Sandra Rodriguez Perales, María José Calasanz, Jose Roman-Gómez, Reiner Siebert, James C Mulloy, José Cervera, Miguel Angel Sanz, Manel Esteller, Juan C Cigudosa
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12197 (2010)
Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemia (AML) pathophysiology. However, further studies to discuss the prognostic value and the relationship of the epigenetic signatures with defined genomic rearrange
Externí odkaz:
https://doaj.org/article/918841f8100945f982ac9470a6b6b0c6
Autor:
Paul Milne, Helen J. Blair, Cornelia Eckert, Zoya Kingsbury, Matthew Collin, Anetta Ptasinska, Alex Elder, Roderick Skinner, Janine Stutterheim, Jennifer Becq, Elena Zerkalenkova, Constanze Bonifer, Denis M. Schewe, Peter N. Cockerill, N Martinez-Soria, Oskar A. Haas, Peter Carey, Katarzyna Szoltysek, Deepali Pal, Hesta McNeill, Claus Meyer, Maria Rosaria Imperato, James C. Mulloy, Mark Wunderlich, Catherine Cargo, Paul Evans, Sarah E. Fordham, Shan Lin, Pierre Cauchy, Y Shi, Simon Bailey, Salam A. Assi, Rolf Marschalek, Josef Vormoor, Olaf Heidenreich, A Komkov, Michael J. Thirman, Simon Bomken, Ricky Tirtakusuma, Sirintra Nakjang, Fotini Vogiatzi, James M. Allan, Lisa J. Russell, Jayne Y. Hehir-Kwa, Muzlifah Haniffa, Yulia Olshanskaya, Vasily V. Grinev, Christine J. Harrison, Venetia Bigley, Daniel Williamson, Alex Smith, Natalia Miakova
Publikováno v:
Blood. 140:1875-1890
The fusion gene MLL-AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. However, relapse can be associated with a switch from acute lymphoblastic to acute myeloid leukaemia. Here we show that these myeloid relapses share oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc1d67bb85567d28d48decb91162f8
https://doi.org/10.1182/blood.2021015036
https://doi.org/10.1182/blood.2021015036
Autor:
Yangchan Li, Xiaolan Deng, Lei Dong, Li Han, Le Xuan Truong Nguyen, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Meilin Xue, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C Mulloy, Bin Zhang, David A Horne, Steve T Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Rui Su, Jianjun Chen
Publikováno v:
Blood. 140:2975-2977
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f89d9bf19708a87a32abbe356b59662
https://doi.org/10.1182/blood-2022-162619
https://doi.org/10.1182/blood-2022-162619
Autor:
Carine Bouffi, Kathryn A. Wikenheiser-Brokamp, Praneet Chaturvedi, Nambirajan Sundaram, Gillian R. Goddard, Mark Wunderlich, Nicole E. Brown, Janet F. Staab, Rachel Latanich, Nicholas C. Zachos, Emily M. Holloway, Maxime M. Mahe, Holly M. Poling, Simon Vales, Garrett W. Fisher, Jason R. Spence, James C. Mulloy, Aaron M. Zorn, James M. Wells, Michael A. Helmrath
Publikováno v:
Nature Biotechnology.
Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable model for investigating human intestinal organogenesis and physiology, but they lack the immune components required to fully recapitulate the complexity of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce9faf21e848f4514f04985168e1376
https://doi.org/10.1038/s41587-022-01558-x
https://doi.org/10.1038/s41587-022-01558-x
Autor:
Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama
Publikováno v:
EMBO molecular medicineReferences.
Inosine monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme in de novo guanine nucleotide synthesis pathway. Although IMPDH inhibitors are widely used as effective immunosuppressants, their antitumor effects have not been proven in the clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1794d97dd2d4857c2bef277c60e3907
https://pubmed.ncbi.nlm.nih.gov/36453131
https://pubmed.ncbi.nlm.nih.gov/36453131
Autor:
Hengyou, Weng, Feng, Huang, Zhaojin, Yu, Zhenhua, Chen, Emily, Prince, Yalin, Kang, Keren, Zhou, Wei, Li, Jiacheng, Hu, Chen, Fu, Tursunjan, Aziz, Hongzhi, Li, Jingwen, Li, Ying, Yang, Li, Han, Subo, Zhang, Yuelong, Ma, Mingli, Sun, Huizhe, Wu, Zheng, Zhang, Mark, Wunderlich, Sean, Robinson, Daniel, Braas, Johanna Ten, Hoeve, Bin, Zhang, Guido, Marcucci, James C, Mulloy, Keda, Zhou, Hong-Fang, Tao, Xiaolan, Deng, David, Horne, Minjie, Wei, Huilin, Huang, Jianjun, Chen
Publikováno v:
Cancer cell. 40(12)
N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a47b001c9922586b27780559c51dd9e1
https://pubmed.ncbi.nlm.nih.gov/36306790
https://pubmed.ncbi.nlm.nih.gov/36306790
Autor:
Laura Barreyro, Avery M. Sampson, Chiharu Ishikawa, Kathleen M. Hueneman, Kwangmin Choi, Mario A. Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy D. Haffey, Eric O’Brien, Mark Wunderlich, Vighnesh Ramesh, Ellen M. Kolb, Cem Meydan, Yaseswini Neelamraju, Lyndsey C. Bolanos, Susanne Christie, Molly A. Smith, Madeline Niederkorn, Tomoya Muto, Santosh Kesari, Francine E. Garrett-Bakelman, Boris Bartholdy, Britta Will, Matthew T. Weirauch, James C. Mulloy, Zartash Gul, Stephen Medlin, Rhett A. Kovall, Ari M. Melnick, John P. Perentesis, Kenneth D. Greis, Elmar Nurmemmedov, William L. Seibel, Daniel T. Starczynowski
Publikováno v:
Science Translational Medicine. 14
Dysregulation of innate immune signaling pathways is implicated in various hematologic malignancies. However, these pathways have not been systematically examined in acute myeloid leukemia (AML). We report that AML hematopoietic stem and progenitor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab19353bdab9af25346ff03b6c548f8
https://doi.org/10.1126/scitranslmed.abb7695
https://doi.org/10.1126/scitranslmed.abb7695