Zobrazeno 1 - 10
of 221
pro vyhledávání: '"James C Mullikin"'
Autor:
Meghan L Rudd, Nancy F Hansen, Xiaolu Zhang, Mary Ellen Urick, Suiyuan Zhang, Maria J Merino, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program, James C Mullikin, Lawrence C Brody, Daphne W Bell
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0251286 (2022)
Endometrioid endometrial carcinomas (EECs) are the most common histological subtype of uterine cancer. Late-stage disease is an adverse prognosticator for EEC. The purpose of this study was to analyze EEC exome mutation data to identify late-stage-sp
Externí odkaz:
https://doaj.org/article/ab394995d00440a9bcc81226a3738c76
Autor:
Zhi Liu, Daniel Shriner, Nancy F Hansen, Charles N Rotimi, James C Mullikin, NISC Comparative Sequencing Program
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232048 (2020)
Hypertension occurs at a higher rate in African Americans than in European Americans. Based on the assumption that causal variants are more frequently found on DNA segments inherited from the ancestral population with higher disease risk, we employed
Externí odkaz:
https://doaj.org/article/5148fe86c9f14437a04f753e6c72684b
Autor:
Stephen W Hartley, James C Mullikin, David C Klein, Morgan Park, NISC Comparative Sequencing Program, Steven L Coon
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163590 (2016)
Alternative isoform regulation (AIR) vastly increases transcriptome diversity and plays an important role in numerous biological processes and pathologies. However, the detection and analysis of isoform-level differential regulation is difficult, par
Externí odkaz:
https://doaj.org/article/64ce8b535d2849c4aaddd1197f2e6551
Autor:
Cinque Soto, Gilad Ofek, M Gordon Joyce, Baoshan Zhang, Krisha McKee, Nancy S Longo, Yongping Yang, Jinghe Huang, Robert Parks, Joshua Eudailey, Krissey E Lloyd, S Munir Alam, Barton F Haynes, NISC Comparative Sequencing Program, James C Mullikin, Mark Connors, John R Mascola, Lawrence Shapiro, Peter D Kwong
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157409 (2016)
Antibody 10E8 targets the membrane-proximal external region (MPER) of HIV-1 gp41, neutralizes >97% of HIV-1 isolates, and lacks the auto-reactivity often associated with MPER-directed antibodies. The developmental pathway of 10E8 might therefore serv
Externí odkaz:
https://doaj.org/article/60b7bd1713514882bff820a0623ed3bb
Autor:
Stephen W Hartley, Steven L Coon, Luis E Savastano, James C Mullikin, NISC Comparative Sequencing Program, Cong Fu, David C Klein
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137548 (2015)
The term neurotranscriptomics is used here to describe genome-wide analysis of neural control of transcriptomes. In this report, next-generation RNA sequencing was using to analyze the effects of neonatal (5-days-of-age) surgical stimulus deprivation
Externí odkaz:
https://doaj.org/article/1f9760fabe7d41b8853daefb4e5cea8e
Autor:
Alexander Pemov, Heejong Sung, Paula L Hyland, Jennifer L Sloan, Sarah L Ruppert, Andrea M Baldwin, Joseph F Boland, Sara E Bass, Hyo Jung Lee, Kristine M Jones, Xijun Zhang, NISC Comparative Sequencing Program, James C Mullikin, Brigitte C Widemann, Alexander F Wilson, Douglas R Stewart
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004575 (2014)
Neurofibromatosis type 1 (NF1) is an autosomal dominant, monogenic disorder of dysregulated neurocutaneous tissue growth. Pleiotropy, variable expressivity and few NF1 genotype-phenotype correlates limit clinical prognostication in NF1. Phenotype com
Externí odkaz:
https://doaj.org/article/61d966c166c5493f8b7e3ef1f0ceb36e
Autor:
Amy R Bentley, Guanjie Chen, Daniel Shriner, Ayo P Doumatey, Jie Zhou, Hanxia Huang, James C Mullikin, Robert W Blakesley, Nancy F Hansen, Gerard G Bouffard, Praveen F Cherukuri, Baishali Maskeri, Alice C Young, Adebowale Adeyemo, Charles N Rotimi
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004190 (2014)
Although a considerable proportion of serum lipids loci identified in European ancestry individuals (EA) replicate in African Americans (AA), interethnic differences in the distribution of serum lipids suggest that some genetic determinants differ by
Externí odkaz:
https://doaj.org/article/a6ff9c59fd2b4be3a0fefce070b59727
Autor:
Jessica C Price, Lana M Pollock, Meghan L Rudd, Sarah K Fogoros, Hassan Mohamed, Christin L Hanigan, Matthieu Le Gallo, NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Suiyuan Zhang, Pedro Cruz, Praveen F Cherukuri, Nancy F Hansen, Kirk J McManus, Andrew K Godwin, Dennis C Sgroi, James C Mullikin, Maria J Merino, Philip Hieter, Daphne W Bell
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63313 (2014)
Most endometrial cancers can be classified histologically as endometrioid, serous, or clear cell. Non-endometrioid endometrial cancers (NEECs; serous and clear cell) are the most clinically aggressive of the three major histotypes and are characteriz
Externí odkaz:
https://doaj.org/article/3e6912cd2b044f93a13ec39d39f4d8c9
Autor:
Hasan Alhaddad, Razib Khan, Robert A Grahn, Barbara Gandolfi, James C Mullikin, Shelley A Cole, Timothy J Gruffydd-Jones, Jens Häggström, Hannes Lohi, Maria Longeri, Leslie A Lyons
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53537 (2013)
Domestic cats have a unique breeding history and can be used as models for human hereditary and infectious diseases. In the current era of genome-wide association studies, insights regarding linkage disequilibrium (LD) are essential for efficient ass
Externí odkaz:
https://doaj.org/article/1d5f4d3f614b414e82519543dbddf701
Autor:
Barbara Gandolfi, Hasan Alhaddad, Verena K Affolter, Jeffrey Brockman, Jens Haggstrom, Shannon E K Joslin, Amanda L Koehne, James C Mullikin, Catherine A Outerbridge, Wesley C Warren, Leslie A Lyons
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67105 (2013)
The cat (Felis silvestris catus) shows significant variation in pelage, morphological, and behavioral phenotypes amongst its over 40 domesticated breeds. The majority of the breed specific phenotypic presentations originated through artificial select
Externí odkaz:
https://doaj.org/article/7f19125aaeb745c18e89e9affeb86875