Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James C McGuire"'
Autor:
Clothier Michael F, Fred E. Dutton, James C McGuire, John P. Davis, David P. Thompson, Timothy G. Geary, Jerry W. Bowman, Eileen M. Thomas, Byung H. Lee, Sandra S. Johnson, Marjorie R. Zantello, Erich W. Zinser
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(12)
Following our discovery of the strong binding of thiadiazole 1 to the AF-2 neuropeptide receptor of gastrointestinal nematodes (e.g., Ascaris suum), we prepared two series of analogs. Only the series containing the thiadiazole ring had potencies comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3313052507fadfa95cb5353d5a7e8d93
https://pubmed.ncbi.nlm.nih.gov/10397509
https://pubmed.ncbi.nlm.nih.gov/10397509
Autor:
James C. McGuire, Frank F. Sun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 794:56-64
Human neutrophils stimulated with calcium ionophore A23187 synthesized 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B 4 . Time-course studies showed that the concentrations of both products reached a maximum after 2 min after which the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::858c50e94890d6702ac603bc9da5a272
https://doi.org/10.1016/0005-2760(84)90297-2
https://doi.org/10.1016/0005-2760(84)90297-2
Autor:
Frank F. Sun, James C. McGuire
Publikováno v:
Prostaglandins. 26:211-221
6, 9-Deepoxy-6, 9-(phenylimino)-Δ 6, 8-prostaglandin I1 (U-60257) and its methyl ester (U-56467) are selective inhibitors of leukotriene C and D biosynthesis both in vitro and in vivo . In this study, we demonstrated that the principal site of inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a510e1a87adb9aef91d6e75ce83d7322
https://doi.org/10.1016/0090-6980(83)90090-4
https://doi.org/10.1016/0090-6980(83)90090-4
Publikováno v:
Prostaglandins. 16:901-910
Nonspecific resistance to infectious and neoplastic disease can be enhanced by administration of "immunomodulators". The levels of enhancement can be monitored by following in vitro function of cells of the lympho-reticuloendothelial system. To gain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfc3189183be5b29990a62d898b5ae0
https://doi.org/10.1016/0090-6980(78)90105-3
https://doi.org/10.1016/0090-6980(78)90105-3
Publikováno v:
Kidney International. 19(6):760-770
Since the early report of Lee et a! [1] describing a vasoactive acidic lipid in the rabbit renal medulla, the kidney has been recognized as a major site of prostaglandin metabolism in the body. In fact, the kidney medulla is one of the richest source
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8650ce121e69ffb3a56d637c1dda1828
Publikováno v:
Prostaglandins. 30:949-967
Several tumor-derived murine macrophage cell lines were evaluated in vitro as cloned prototypes of tissue macrophages for their ability to metabolize arachidonic acid. Unexpectedly, two cell lines, J774A.1 and WR19M.1, rapidly converted exogenous 14C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943ec7b73c099216d7fec9cc52b1f5de
https://doi.org/10.1016/0090-6980(85)90168-6
https://doi.org/10.1016/0090-6980(85)90168-6
Publikováno v:
Prostaglandins. 21:609-614
(5E)-6a-Carbaprostaglandin I 2 (carbacyclin) was oxidized to (5E)-15-dehydro-6a-carbaprostaglandin I 2 (15-dehydrocarbacyclin) by partially purified rhesus monkey lung prostaglandin dehydrogenase (PGDH). The (5E)-15-dehydro-6a-carbaprostaglandin I 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1387be49315b5ccae36de1a3cd55b6
https://doi.org/10.1016/0090-6980(81)90009-5
https://doi.org/10.1016/0090-6980(81)90009-5
Autor:
Robert J. Smith, Howard Sprecher, Barbara J. Bowman, Susan S. Iden, Frank F. Sun, James C. McGuire
Publikováno v:
Clinical Immunology and Immunopathology. 20:157-169
Exposure of neutrophils to the calcium ionophore A23187 (5 μ M ) resulted in a time-dependent generation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) and the selective release of the granule-associated enzymes, β-glucuronidase and lysozyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf8c4248e01a7e157ab1bb2081b8386
https://doi.org/10.1016/0090-1229(81)90174-4
https://doi.org/10.1016/0090-1229(81)90174-4
Autor:
James C. McGuire
Publikováno v:
Transactions of the American Society of Civil Engineers. 26:1-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b77f92b4763fd582797b5e88a82961
https://doi.org/10.1061/taceat.0000885
https://doi.org/10.1061/taceat.0000885
Autor:
S. Bunting, John A. Salmon, Salvador Moncada, James C. McGuire, Norman Whittaker, John R. Vane, Roy A. Johnson, Frank F. Sun, Robert R. Gorman, Douglas R. Morton, John H. Kinner
The chemical structure of prostaglandin I, the anti-aggretory substance derived from prostaglandin endoperoxides , is 9-deoxy-6, 9α-epoxy-Δ 5 -PGF 1 α .The stable compound formed when prostaglandin X undergoes a chemical transformation in biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e72f553548ddc5a38feff99155319e31
https://doi.org/10.1016/b978-0-12-405850-7.50017-5
https://doi.org/10.1016/b978-0-12-405850-7.50017-5
