Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James C McGann"'
Autor:
James C McGann, Jon A Oyer, Saurabh Garg, Huilan Yao, Jun Liu, Xin Feng, Lujian Liao, John R Yates III, Gail Mandel
Publikováno v:
eLife, Vol 3 (2014)
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Represso
Externí odkaz:
https://doaj.org/article/2a4aa1e04ef24e799bc1edd34a168a7f
Autor:
Virginie Olive, Erich Sabio, Margaux J Bennett, Caitlin S De Jong, Anne Biton, James C McGann, Samantha K Greaney, Nicole M Sodir, Alicia Y Zhou, Asha Balakrishnan, Mona Foth, Micah A Luftig, Andrei Goga, Terence P Speed, Zhenyu Xuan, Gerard I Evan, Ying Wan, Alex C Minella, Lin He
Publikováno v:
eLife, Vol 2 (2013)
mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 exhibits potent oncogenic activity by repressing c-Myc-induced apoptosis, primarily through
Externí odkaz:
https://doaj.org/article/40ffbb1f349b467aad6234770c960db3
Autor:
Randall L. Woltjer, James C. McGann, Karin Mullendorff, Gail Mandel, Michael A. Spinner, Saurabh K. Garg
Publikováno v:
J Neurosci
Early studies in mouse neurodevelopment led to the discovery of the RE1 Silencing Transcription Factor (REST) and its role as a master repressor of neuronal gene expression. Recently, REST was reported to also repress neuronal genes in the human adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bac05aedf139f4e54b180c5ddd5c690
https://doi.org/10.1523/jneurosci.2059-20.2021
https://doi.org/10.1523/jneurosci.2059-20.2021
Autor:
Gail Mandel, James C. McGann
Publikováno v:
Glia. 66:2024-2039
The idea that astrocytes provide support for neurons has a long history, but whether neurons play an instructive role in these processes is poorly understood. To address this question, we co-culture astrocytes with genetically labeled neurons, permit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ed9a93d67145cae5ffd02cd2ed9304
https://doi.org/10.1002/glia.23455
https://doi.org/10.1002/glia.23455
Autor:
Kim Newton, Sarah G. Hymowitz, XiaoDong Huang, Anthony Wynshaw-Boris, Michael Kakunda, Christine Yu, Paul Polakis, Victoria Pham, Jo Anne Hongo, Jennie R. Lill, Bob Y. Liu, Rami N. Hannoush, Richard M. Harland, James C. McGann, Jinfeng Liu, Vishva M. Dixit
Publikováno v:
Science. 339:1441-1445
Receptor interacting protein kinase 4 (RIPK4) is required for epidermal differentiation (1–4) and is mutated in Bartsocas-Papas syndrome (5, 6). While RIPK4 binds protein kinase C (5, 6), RIPK4 signaling mechanisms are largely unknown. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be54393ccf5fd6e5ea2f1d849268b4c4
https://doi.org/10.1126/science.1232253
https://doi.org/10.1126/science.1232253
Autor:
Thomas Floss, Karin Mullendorff, Wolfgang Wurst, Jenny Hsieh, James C. McGann, Tamilla Nechiporuk, Gail Mandel
Publikováno v:
eLife 5:e09584 (2016)
eLife 5, e09584 (2016). doi:10.7554/eLife.09584
eLife, Vol 5 (2016)
eLife 5, e09584 (2016). doi:10.7554/eLife.09584
eLife, Vol 5 (2016)
The timely transition from neural progenitor to post-mitotic neuron requires down-regulation and loss of the neuronal transcriptional repressor, REST. Here, we have used mice containing a gene trap in the Rest gene, eliminating transcription from all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32568c1437b479aa702f2e80ae2f16a
https://doi.org/10.7554/elife.09584
https://doi.org/10.7554/elife.09584
Autor:
Saurabh K. Garg, James C. McGann, Huilan Yao, Xin Feng, Gail Mandel, Jun Liu, Lujian Liao, John R. Yates, Jon A Oyer
Publikováno v:
eLife, Vol 3 (2014)
eLife
eLife
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Represso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0203a8f83ae5236e4b2b6d6dfe5244e8
https://elifesciences.org/articles/04235
https://elifesciences.org/articles/04235
Autor:
Lin He, Mona Foth, Erich Sabio, Caitlin S De Jong, Terence P. Speed, Zhenyu Xuan, Ying Wan, Margaux J Bennett, Nicole M. Sodir, Alicia Y. Zhou, James C. McGann, Anne Biton, Andrei Goga, Virginie Olive, Samantha K Greaney, Micah A. Luftig, Alex C. Minella, Asha Balakrishnan, Gerard I. Evan
Publikováno v:
eLife
eLife, Vol 2 (2013)
eLife, Vol 2 (2013)
mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 exhibits potent oncogenic activity by repressing c-Myc-induced apoptosis, primarily through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40744bf0f1b44936e24f98878cec405
http://europepmc.org/articles/PMC3796314
http://europepmc.org/articles/PMC3796314