Zobrazeno 1 - 10
of 247
pro vyhledávání: '"James C Iatridis"'
Autor:
Devorah M Natelson, Alon Lai, Divya Krishnamoorthy, Robert C Hoy, James C Iatridis, Svenja Illien-Jünger
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0227527 (2020)
Type 2 diabetes and obesity are associated with back pain in juveniles and adults and are implicated in intervertebral disc (IVD) degeneration. Hypercaloric Western diets are associated with both obesity and type 2 diabetes. The objective of this stu
Externí odkaz:
https://doaj.org/article/96d5e4c409cb45338ed2d60d9828eb94
Autor:
Kengo Fujii, Masashi Yamazaki, James D Kang, Makarand V Risbud, Samuel K Cho, Sheeraz A Qureshi, Andrew C Hecht, James C Iatridis
Publikováno v:
JBMR Plus, Vol 3, Iss 5, Pp n/a-n/a (2019)
Abstract Discogenic back pain is multifactorial; hence, physicians often struggle to identify the underlying source of the pain. As a result, discogenic back pain is often hard to treat—even more so when clinical treatment strategies are of questio
Externí odkaz:
https://doaj.org/article/ad8b95f5fa314062942b1d7cbfdcb389
Autor:
Alon Lai, Lap Ho, Thomas W Evashwick-Rogler, Hironobu Watanabe, Jonathan Salandra, Beth A Winkelstein, Damien Laudier, Andrew C Hecht, Giulio M Pasinetti, James C Iatridis
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225674 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0223435.].
Externí odkaz:
https://doaj.org/article/e479ee6b189e401086ce53da05f478f1
Autor:
Warren W Hom, Melanie Tschopp, Huizi A Lin, Philip Nasser, Damien M Laudier, Andrew C Hecht, Steven B Nicoll, James C Iatridis
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217357 (2019)
Back pain commonly arises from intervertebral disc (IVD) damage including annulus fibrosus (AF) defects and nucleus pulposus (NP) loss. Poor IVD healing motivates developing tissue engineering repair strategies. This study evaluated a composite injec
Externí odkaz:
https://doaj.org/article/60a6f1d18cd543649c340d22db7e7a47
Autor:
Alon Lai, Lap Ho, Thomas W Evashwick-Rogler, Hironobu Watanabe, Jonathan Salandra, Beth A Winkelstein, Damien Laudier, Andrew C Hecht, Giulio M Pasinetti, James C Iatridis
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223435 (2019)
Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are
Externí odkaz:
https://doaj.org/article/2d3a83857bdd4963a72bdadab1e4d815
Autor:
Danielle N. D’Erminio, Kaya A. Adelzadeh, Ashley M. Rosenberg, Robert J. Wiener, Olivia M. Torre, Emily D. Ferreri, Philip Nasser, Kevin D. Costa, Woojin M. Han, Alice H. Huang, James C. Iatridis
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110883- (2024)
Summary: Intervertebral disc (IVD) defects heal poorly and can cause back pain and disability. We identified that IVD herniation injury heals regeneratively in neonatal mice until postnatal day 14 (p14) and shifts to fibrotic healing by p28. This age
Externí odkaz:
https://doaj.org/article/ee8939875d934d66b1c0389ff1beea90
Autor:
Svenja Illien-Jünger, Young Lu, Sheeraz A Qureshi, Andrew C Hecht, Weijing Cai, Helen Vlassara, Gary E Striker, James C Iatridis
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116625 (2015)
Intervertebral disc (IVD) degeneration and pathological spinal changes are major causes of back pain, which is the top cause of global disability. Obese and diabetic individuals are at increased risk for back pain and musculoskeletal complications. M
Externí odkaz:
https://doaj.org/article/735e3aab609941b2b1b81f399b10bb77
Autor:
Benjamin A Walter, Morakot Likhitpanichkul, Svenja Illien-Junger, Peter J Roughley, Andrew C Hecht, James C Iatridis
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118358 (2015)
Intervertebral disc (IVD) degeneration is an important contributor to the development of back pain, and a key factor relating pain and degeneration are the presence of pro-inflammatory cytokines and IVD motion. There is surprisingly limited understan
Externí odkaz:
https://doaj.org/article/e84fc30f9a2f4ccbad50e894c1f7e35b
Autor:
Svenja Illien-Junger, Fabrizio Grosjean, Damien M Laudier, Helen Vlassara, Gary E Striker, James C Iatridis
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64302 (2013)
OBJECTIVE:Diabetes and low back pain are debilitating diseases and modern epidemics. Diabetes and obesity are also highly correlated with intervertebral disc (IVD) degeneration and back pain. Advanced-glycation-end-products (AGEs) increase reactive-o
Externí odkaz:
https://doaj.org/article/504515786ae743ccabb7522b11ccc78c
Autor:
Irina Heggli, Graciosa Q. Teixeira, James C. Iatridis, Cornelia Neidlinger‐Wilke, Stefan Dudli
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Disc degeneration and vertebral endplate bone marrow lesions called Modic changes are prevalent spinal pathologies found in chronic low back pain patients. Their pathomechanisms are complex and not fully understood. Recent studies have revea
Externí odkaz:
https://doaj.org/article/f2197514fabb4da59ca9fbcd1e2d86ee