Zobrazeno 1 - 10
of 123
pro vyhledávání: '"James C H Hardwick"'
Autor:
Melianthe P J Nicolai, Josbert J Keller, Lieke de Vries, Andrea E van der Meulen-de Jong, Jan J Nicolai, James C H Hardwick, Hein Putter, Rob C M Pelger, Henk W Elzevier
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85034 (2014)
BACKGROUND: Sexual abuse has been linked to strong effects on gastrointestinal health. Colonoscopy can provoke intense emotional reactions in patients with a sexual abuse history and may lead to avoidance of endoscopic procedures. OBJECTIVE: To deter
Externí odkaz:
https://doaj.org/article/72337a2acbc346478bc9762873bfe65a
Autor:
Nik Dekkers, Elham Zonoobi, Hao Dang, Mats I. Warmerdam, Stijn Crobach, Alexandra M. J. Langers, Jolein van der Kraan, Denise E. Hilling, Koen C. M. J. Peeters, Fabian A. Holman, Alexander L. Vahrmeijer, Cornelis F. M. Sier, James C. H. Hardwick, Jurjen J. Boonstra
Publikováno v:
None
United European Gastroenterology Journal, 11(3), 282-292. SAGE Publishing
United European Gastroenterology Journal, 11(3), 282-292. SAGE Publishing
BackgroundDifferentiating high-grade dysplasia (HGD) and T1 colorectal cancer (T1CRC) from low-grade dysplasia (LGD) in colorectal polyps can be challenging. Incorrect recognition of HGD or T1CRC foci can lead to a need for additional treatment after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6def3a7f6e124d2243045d9622ee63a
http://hdl.handle.net/1887/3620697
http://hdl.handle.net/1887/3620697
Autor:
Manon E. Wildenberg, Liudmila L. Kodach, Gwenny M. Fuhler, Lukas J. A. C. Hawinkels, Jarom Heijmans, Maikel P. Peppelenbosch, Rutger J. Jacobs, Philip W. Voorneveld, Sarah Ouahoud, James C. H. Hardwick, Sander H. Diks
Publikováno v:
Br J Cancer
British Journal of Cancer, 124, 1978-1987. SPRINGERNATURE
British Journal of Cancer, 124(12), 1978-1987. Nature Publishing Group
British journal of cancer, 124(12), 1978-1987. Nature Publishing Group
British Journal of Cancer, 124, 1978-1987. SPRINGERNATURE
British Journal of Cancer, 124(12), 1978-1987. Nature Publishing Group
British journal of cancer, 124(12), 1978-1987. Nature Publishing Group
Background Epidemiological studies and meta-analyses show an association between statin use and a reduced incidence of colorectal cancer (CRC). We have shown that statins act on CRC through bone morphogenetic protein (BMP) signalling, but the exact c
Autor:
Andrew B. Nixon, Madelon Paauwe, Melpomeni Toitou, Charles P. Theuer, Marieke F. Fransen, Marieke C. Barnhoorn, Bryan Koolmoes, Lukas J. A. C. Hawinkels, James C. H. Hardwick, Maaike F.M. Koops, Ricardo A. Angela, Mark J A Schoonderwoerd, Yingmiao Liu, Cornelis F. M. Sier
Publikováno v:
Schoonderwoerd, M J A, Koops, M F M, Angela, R A, Koolmoes, B, Toitou, M, Paauwe, M, Barnhoorn, M C, Liu, Y, Sier, C F M, Hardwick, J C H, Nixon, A B, Theuer, C P, Fransen, M F & Hawinkels, L J A C 2020, ' Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy ', Clinical Cancer Research, vol. 26, no. 14, pp. 3831-3842 . https://doi.org/10.1158/1078-0432.CCR-19-2889
Clinical Cancer Research, 26(14), 3831-3842. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 26(14), 3831-3842. American Association for Cancer Research Inc.
Clinical Cancer Research, 26(14), 3831-3842. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 26(14), 3831-3842. American Association for Cancer Research Inc.
Purpose: Endoglin is a coreceptor for TGFβ ligands that is highly expressed on proliferating endothelial cells and other cells in the tumor microenvironment. Clinical studies have noted increased programmed cell death (PD)-1 expression on cytotoxic
Autor:
Thijs W de Vos, Gabi W. van Pelt, Mark J A Schoonderwoerd, Eveline S.M. de Jonge-Muller, Philip W. Voorneveld, Madelon Paauwe, Sarah Ouahoud, Lukas J. A. C. Hawinkels, Wilma E. Mesker, James C. H. Hardwick, Sophie de Wit, Lennart R A van der Burg
Publikováno v:
Oncogene, 39, 2453-2466. NATURE PUBLISHING GROUP
Patients with the mesenchymal subtype colorectal cancer (CRC) have a poor prognosis, in particular patients with stroma-rich tumors and aberrant SMAD4 expression. We hypothesized that interactions between SMAD4-deficient CRC cells and cancer-associat
Autor:
Zeinab Ghorbanoghli, Mariëtte van Kouwen, Birgitta Versluys, Delphine Bonnet, Christine Devalck, Julie Tinat, Danuta Januszkiewicz-Lewandowska, Consuelo Calvino Costas, Edouard Cottereau, James C H Hardwick, Katharina Wimmer, Laurence Brugieres, Chrystelle Colas, Hans F A Vasen
Publikováno v:
Journal of Medical Genetics. BMJ PUBLISHING GROUP
Journal of Medical Genetics
Journal of Medical Genetics
BackgroundConstitutional mismatch repair deficiency (CMMRD) is a rare autosomal recessively inherited syndrome that is caused by biallelic pathogenic variants of the mismatch repair genes. It is characterised by the development of multiple tumours in
Autor:
Tom van Wezel, Ron M. C. Herings, Britt van Vliet, Lukas J. A. C. Hawinkels, James C. H. Hardwick, Rutger J. Jacobs, Ludmilla L. Kodach, Philip W. Voorneveld, Sarah Ouahoud, Hans Morreau, Marije Slingerland, Esther Bastiaannet, Hein Putter, Nikki L. Weil, Lennart R A van der Burg
Publikováno v:
Ouahoud, S, Jacobs, R J, Kodach, L L, Voorneveld, P W, Hawinkels, L J A C, Weil, N L, van Vliet, B, Herings, R M, van der Burg, L R A, van Wezel, T, Morreau, H, Slingerland, M, Bastiaannet, E, Putter, H & Hardwick, J C H 2022, ' Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4 ', British Journal of Cancer, vol. 126, no. 2, pp. 297-301 . https://doi.org/10.1038/s41416-021-01604-6
British Journal of Cancer. SPRINGERNATURE
British Journal of Cancer
British Journal of Cancer, 126(2), 297-301. Nature Publishing Group
Br J Cancer
British Journal of Cancer. SPRINGERNATURE
British Journal of Cancer
British Journal of Cancer, 126(2), 297-301. Nature Publishing Group
Br J Cancer
BACKGROUND: Long-term use of statins is associated with a small reduced risk of colorectal cancer but their mechanism of action is not well understood. While they are generally believed to act on KRAS, we have previously proposed that they act via in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee94a4827fa764a30634a966aa9f83e
https://hdl.handle.net/1887/3264145
https://hdl.handle.net/1887/3264145
Autor:
James C H, Hardwick
Publikováno v:
Endoscopy. 54(2)
Autor:
G. Johan A. Offerhaus, Peter D. Siersema, John N. Groen, Yara Backes, Jeroen D van Bergeijk, Rob A. E. M. Tollenaar, Lodewijk A. A. Brosens, Miangela M Lacle, Sjoerd G. Elias, Lukas J. A. C. Hawinkels, Wilma E. Mesker, Anja U.G. van Lent, Leon M G Moons, Hao Dang, Krijn J. C. Haasnoot, Gabi W. van Pelt, C A Seldenrijk, Frank ter Borg, Bernhard W M Spanier, Anya N A Milne, Mihaela G. Raicu, T. C. Seerden, Frank H J Wolfhagen, Joost M J Geesing, Matthijs P. Schwartz, Jurjen J. Boonstra, James C. H. Hardwick, Wouter H. de Vos tot Nederveen Cappel, Koen Kessels
Publikováno v:
United European Gastroenterology Journal
United European Gastroenterology Journal, 9(4), 478-485. SAGE PUBLICATIONS INC
United European Gastroenterology Journal, 9, 478-485
United European Gastroenterology Journal, 9, pp. 478-485
United European Gastroenterology Journal, 9(4), 478-485. SAGE PUBLICATIONS INC
United European Gastroenterology Journal, 9, 478-485
United European Gastroenterology Journal, 9, pp. 478-485
Contains fulltext : 244720.pdf (Publisher’s version ) (Open Access) BACKGROUND: Current risk stratification models for early invasive (T1) colorectal cancer are not able to discriminate accurately between prognostic favourable and unfavourable tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c181f3040a2b6c84c225ae0b0e53e287
https://hdl.handle.net/1887/3196041
https://hdl.handle.net/1887/3196041
Autor:
Marieke L. de Kam, Arend Karrenbeld, Jessie Westerhof, Iris Schmidt, Jan J. Koornstra, Ingrid M C Kamerling, Wouter B. Nagengast, F. J. Voskuil, James C. H. Hardwick, Steven J de Jongh, Dominic J. Robinson, Josephina P.M. Vrouwe, Jacobus Burggraaf
Publikováno v:
Journal of Nuclear Medicine, 61(10), 1435-1441. SOC NUCLEAR MEDICINE INC
Journal of Nuclear Medicine, 61(10), 1435-1441. Society of Nuclear Medicine and Molecular Imaging
Journal of Nuclear Medicine, 61(10), 1435-1441. Society of Nuclear Medicine and Molecular Imaging
Fluorescence molecular endoscopy (FME) is an emerging technique that has the potential to improve the 22% colorectal polyp detection miss-rate. We determined the optimal dose-to-imaging interval and safety of FME using EMI-137, a c-Met-targeted fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c611f0f8192fd3ae64d20e23297406e9
https://doi.org/10.2967/jnumed.119.238790
https://doi.org/10.2967/jnumed.119.238790