Zobrazeno 1 - 10
of 141
pro vyhledávání: '"James C Fuscoe"'
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170813 (2017)
Stably Expressed Genes (SEGs) whose expression varies within a narrow range may be involved in core cellular processes necessary for basic functions. To identify such genes, we re-analyzed existing RNA-Seq gene expression profiles across 11 organs at
Externí odkaz:
https://doaj.org/article/48a679f094204767975ce800afa96979
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0117047 (2015)
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Moreover, sex and age are considered major risk factors in the development of CVDs. Mitochondria are vital for normal cardiac function, and regulation of mitochondrial structur
Externí odkaz:
https://doaj.org/article/53cfbb0cd6ab4d82bb07aee0f8b157b7
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75305 (2013)
Age is a predisposing condition for susceptibility to chronic kidney disease and progression as well as acute kidney injury that may arise due to the adverse effects of some drugs. Age-related differences in kidney biology, therefore, are a key conce
Externí odkaz:
https://doaj.org/article/0b9472c323f54218b1a985a04e0c7179
Autor:
Varsha G. Desai, Ana Azevedo‐Pouly, Vikrant Vijay, Bounleut Phanavanh, Carrie L. Moland, Tao Han, Javier Revollo, Baikuntha Aryal, V. Ashutosh Rao, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES.
Preclinical and clinical findings suggest sexual dimorphism in cardiotoxicity induced by a chemotherapeutic drug, doxorubicin (DOX). However, molecular alterations leading to sex-related differential vulnerability of heart to DOX toxicity are not ful
Autor:
Varsha G. Desai, Vikrant Vijay, Taewon Lee, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Eugene H. Herman, Kimo Stine, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(9)
Cardiotoxicity is a serious adverse effect of an anticancer drug, doxorubicin (DOX), which can occur within a year or decades after completion of therapy. The present study was designed to address a knowledge gap concerning a lack of circulating biom
Autor:
Yongxiang Zhao, Zhichao Liu, Jian He, Tieliu Shi, James C. Fuscoe, Xiangjun Ji, Jinghua Liu, Paweł P. Łabaj, Wenjun Bao, David P. Kreil, Geng Chen, Leming Shi, Peng Li, Liping Zhong, Baitang Ning, Wenzhong Xiao, Jun Wu, Weida Tong, Yong Huang, Huixiao Hong, Lei Guo
Publikováno v:
Nucleic Acids Research
The rat is an important model organism in biomedical research for studying human disease mechanisms and treatments, but its annotated transcriptome is far from complete. We constructed a Rat Transcriptome Re-annotation named RTR using RNA-seq data fr
Autor:
Varsha G. Desai, Taewon Lee, Carrie L. Moland, Kelly Davis, Vikrant Vijay, Kimo C. Stine, James C. Fuscoe, Tao Han, Bounleut Phanavanh, Levan Muskhelishvili
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(5)
Subclinical cardiotoxicity at low total cumulative doxorubicin (DOX) doses can manifest into cardiomyopathy in long-term cancer survivors. However, the underlying mechanisms are poorly understood. In male B6C3F1 mice, assessment of cardiac function b
Autor:
Yu-Chuan Chen, Noriko Nakamura, Deborah K. Hansen, Tao Han, Barry S. McIntyre, Varsha G. Desai, Wafa Harrouk, Ching-Wei Chang, James C. Fuscoe, Paul M. D. Foster, Amy L. Inselman, Vikrant Vijay
Publikováno v:
Reproductive Toxicology. 82:111-123
2-hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet light-absorbing compound that is used in sunscreens, cosmetics and plastics. HMB has been reported to have weak estrogenic activity by in vivo and in vitro studies, making it a chemical with pot
Autor:
James C. Fuscoe
Publikováno v:
Molecular Toxicology Protocols ISBN: 9781071602225
Molecular Toxicology Protocols ISBN: 9781627037389
Molecular Toxicology Protocols ISBN: 9781627037389
Specific recurring chromosomal translocations and deletions are found in a variety of cancers. In hematopoietic malignancies, many of these chromosomal aberrations result from mistakes involving V(D)J recombination. V(D)J recombination is required fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7ba4cfa994238157a1d8a33ceacd4f
https://doi.org/10.1007/978-1-0716-0223-2_21
https://doi.org/10.1007/978-1-0716-0223-2_21
Autor:
Daniel T. Sloper, Amy L. Inselman, Tao Han, Gwenn E. Merry, J. Edward Fisher, James C. Fuscoe, Deborah K. Hansen, Xinrong Chen, Wafa Harrouk, Melissa S. Tassinari
Publikováno v:
Reproductive Toxicology. 69:75-83
The mouse embryonic stem cell test (mEST) is a promising in vitro assay for predicting developmental toxicity. In the current study, early differentiation of D3 mouse embryonic stem cells (mESCs) under osteoblast culture conditions and embryotoxicity