Zobrazeno 1 - 10 of 84 pro vyhledávání: '"James C Burnett"'
1
Akademický článek
Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.
Autor: Erkan Kiris, Jonathan E Nuss, Stephanie M Stanford, Laura M Wanner, Lisa Cazares, Michael F Maestre, Hao T Du, Glenn Y Gomba, James C Burnett, Rick Gussio, Nunzio Bottini, Rekha G Panchal, Christopher D Kane, Lino Tessarollo, Sina Bavari
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129264 (2015)
There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Al
Externí odkaz: https://doaj.org/article/60298f029db949189b12f9558abf609f
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2
Akademický článek
Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.
Autor: Jorge E Zuniga, Jared T Hammill, Omri Drory, Jonathan E Nuss, James C Burnett, Rick Gussio, Peter Wipf, Sina Bavari, Axel T Brunger
Publikováno v: PLoS ONE, Vol 5, Iss 6, p e11378 (2010)
The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is characteristic of the disease state botulism. Three related peptide-like molecules (PLMs) were designed using p
Externí odkaz: https://doaj.org/article/a34e88d467e840418644c1507b4c85d7
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5
Data from Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy
Autor: Peter Wipf, Rick Gussio, Connor F. McGrath, Melinda G. Hollingshead, James C. Burnett, Joseph M. Salamoun, Ann Hermone, Brian D. Peyser
The preclinical antitumor agent RITA (2,5-bis[5-hydroxymethyl-2-thienyl] furan, NSC 652287), an analog of the natural product α-terthiophene, failed during the development phase due to acute pulmonary toxicity in animal models. A series of synthetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36af6d22a3d3c176d379594b428d0cd6
https://doi.org/10.1158/1535-7163.c.6537751
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7
S ‐(4‐Methoxyphenyl)‐4‐methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent
Autor: Adilson Beatriz, Murilo K. A. Yonekawa, Camilla I. Nantes, Maria de Fatima Cepa Matos, Ruoli Bai, Ernest Hamel, Dênis Pires de Lima, Rodrigo Juliano Oliveira, Edson dos Anjos dos Santos, Renata Trentin Perdomo, James C. Burnett, Ingrid D. Pereira, Danielle Bogo
Publikováno v: ChemMedChem. 15:449-458
Organosulfur compounds show cytotoxic potential towards many tumor cell lines. Disulfides and thiosulfonates act through apoptotic processes, inducing proteins associated with apoptosis, endoplasmic reticulum stress, and the unfolded protein response
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0f1082b9dca8b00da011f886d5e5d0
https://doi.org/10.1002/cmdc.201900566
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8
Methyl Scanning and Revised Binding Mode of 2-Pralidoxime, an Antidote for Nerve Agent Poisoning
Autor: James C. Burnett, Adriana Gambino, Kazunori Koide
Publikováno v: ACS Med Chem Lett
[Image: see text] Organophosphorus nerve agents (OPNAs) inhibit acetylcholinesterase (AChE) and, despite the Chemical Weapons Convention arms control treaty, continue to represent a threat to both military personnel and civilians. 2-Pralidoxime (2-PA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31bbec25465188f698e754b251b5108
https://doi.org/10.1021/acsmedchemlett.9b00586
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9
Akademický článek
A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor
Autor: Rekha G. Panchal, Bogdan A. Šolaja, James C. Burnett, Cary Retterer, Sina Bavari, Brett Eaton, Života Selaković, Dejan Opsenica
Publikováno v: Viruses, Vol 4, Iss 8, Pp 1279-1288 (2012)
Ebola (EBOV) and Marburg (MARV) filoviruses are highly infectious pathogens causing deadly hemorrhagic fever in humans and non-human primates. Promising vaccine candidates providing immunity against filoviruses have been reported. However, the sporad
Externí odkaz: https://doaj.org/article/ba1728c095e74ae3a9c0a9ca0c508689
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10
Akademický článek
Post-Intoxication Inhibition of Botulinum Neurotoxin Serotype A within Neurons by Small-Molecule, Non-Peptidic Inhibitors
Autor: Sina Bavari, Cary J. Retterer, Edna Torres-Melendez, Sarah J. Sandwick, Laura M. Wanner, Lyal E. Tressler, Jonathan E. Nuss, Gordon Ruthel, James C. Burnett
Publikováno v: Toxins, Vol 3, Iss 3, Pp 207-217 (2011)
Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in potentially fatal flaccid paralysis. BoNT serotype A (BoNT/A), which targets synaptosomal-associ
Externí odkaz: https://doaj.org/article/9870667b3dd6453db0a5f49a6ad142f7
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