Zobrazeno 1 - 10
of 585
pro vyhledávání: '"James C Barton"'
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302817 (2024)
BackgroundIgG subclass levels in hemochromatosis are incompletely characterized.MethodsWe characterized IgG subclass levels of referred hemochromatosis probands with HFE p.C282Y/p.C282Y (rs1800562) and human leukocyte antigen (HLA)-A and -B typing/ha
Externí odkaz:
https://doaj.org/article/d8ebbce8a8a94d2aaf4362d02113dee1
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Our aim was to document the effects of genotype HFE p.C282Y/p.C282Y and hemochromatosis-associated laboratory and clinical manifestations on platelet counts (PC). We compiled genotype (p.C282Y/p.C282Y or HFE wt/wt (absence of p.C282Y and p.H63D (rs17
Externí odkaz:
https://doaj.org/article/e17c4c19a4884c9facabb334813a2534
Publikováno v:
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background The aim of this study was to identify characteristics of non-alcoholic fatty liver disease (NAFLD) in adults with HFE p.C282Y/p.C282Y. Methods We retrospectively studied non-Hispanic white hemochromatosis probands with iron overlo
Externí odkaz:
https://doaj.org/article/f008c48d4f6a48e388dd3b628fef201b
Publikováno v:
Hereditas, Vol 159, Iss 1, Pp 1-11 (2022)
Abstract Background Human leukocyte antigen (HLA)-A*03, hemochromatosis ancestral haplotype marker, was associated with greater iron overload in hemochromatosis cohorts reported before discovery of the HFE gene. We sought to learn whether an A*03-lin
Externí odkaz:
https://doaj.org/article/6d7ed3a5e6e54341b1680e4979fd4d18
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Factors associated with IgG levels in adults with IgG subclass deficiency (IgGSD) are incompletely understood. We studied adults with IgGSD with subnormal IgG1 only, subnormal IgG1/IgG3, or subnormal IgG3 only without other subnor
Externí odkaz:
https://doaj.org/article/b301cb7e8c5349869d469f469d632d9a
Autor:
Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular ba
Externí odkaz:
https://doaj.org/article/2d5a574431c94fcbb245e3571e64248d
Publikováno v:
PLoS ONE, Vol 17, Iss 7 (2022)
Background Screening program participants with iron overload (IO) phenotypes without HFE p.C282Y/p.C282Y are incompletely characterized. Methods We studied white participants who had IO phenotypes without p.C282Y/p.C282Y in post-screening clinical ex
Externí odkaz:
https://doaj.org/article/fc4b315223564ea289af01c7828e0080
Autor:
Antony R. Parker, Markus Skold, Stephen Harding, J. Clayborn Barton, Luigi F. Bertoli, James C. Barton
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and
Externí odkaz:
https://doaj.org/article/ca7cb5dd003d433c92b24bb272d5cc9d
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background Mannose-binding lectin (MBL) deficiency may increase risk of respiratory tract infection in adults unselected for IgG or IgG subclass levels. In a retrospective study, we sought to determine associations of serum MBL levels with c
Externí odkaz:
https://doaj.org/article/cf1453558b3d4285829699b2f8342fa5
Publikováno v:
Annals of Hepatology, Vol 18, Iss 2, Pp 354-359 (2019)
Introduction and aim: Observations of hepatitis C virus (HCV) infection in adults with hemochromatosis are limited. Materials and methods: We determined associations of serum ferritin (SF) with anti-HCV in non-Hispanic white North American adults in
Externí odkaz:
https://doaj.org/article/bcae32961ef347f2a8c23128ade60e9e