Zobrazeno 1 - 10
of 216
pro vyhledávání: '"James C, Sullivan"'
Autor:
Hui Wang, Yunxiang Dai, Nicholas Clark, Lianne Boeglin, Caroline Woo, Richard Wooster, Gang Sun, James C. Sullivan
Publikováno v:
Translational Medicine Communications, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Background The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a low-abundance membrane protein. The dysfunction of CFTR protein is the fundamental cause of cystic fibrosis (CF), a fatal genetic disease. In recent years
Externí odkaz:
https://doaj.org/article/b2c8c96df2a94a0daa9a958d409d73cb
Autor:
Meredith C. Fidler, Alexandra Buckley, James C. Sullivan, Marvin Statia, Sylvia F. Boj, Robert G. J. Vries, Anne Munck, Mark Higgins, Matteo Moretto Zita, Paul Negulescu, Fredrick vanGoor, Kris De Boeck
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 656-663 (2021)
In previous work, participants with a G970R mutation in cystic fibrosis transmembrane conductance regulator (CFTR) (c.2908G>C) had numerically lower sweat chloride responses during ivacaftor treatment than participants with other CFTR gating mutation
Externí odkaz:
https://doaj.org/article/da813cb3faa54b46b8f5eeca152ec374
Autor:
Malena Cohen-Cymberknoh, Eitan Kerem, Michael Wilschanski, Alex Gileles-Hillel, Christopher Short, C DeSouza, Thea Pugatsch, Reuven Tsabari, Clare Saunders, Joel Reiter, James C. Sullivan, N. Kinnman, David Shoseyov, Jane C. Davies, Jamie R Doyle, Keval Chandarana
Publikováno v:
Annals of the American Thoracic Society. 18:433-441
Rationale: Ivacaftor's clinical effects in the residual function mutations 3849+10kb C →T and D1152H warrant further characterization. Objectives: Evaluate ivacaftor's effect in people with cystic fibrosis aged ≥6 years with 3849+10kb C→T or D1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0731e4c28904795edb4b358651e20d7e
https://doi.org/10.1513/annalsats.202006-659oc
https://doi.org/10.1513/annalsats.202006-659oc
Autor:
James C. Sullivan, Kris De Boeck, Paul A. Negulescu, Anne Munck, Meredith C. Fidler, Mark Higgins, Fredrick Van Goor, Sylvia F. Boj, Matteo Moretto Zita, Alexandra Buckley, Robert G.J. Vries, Marvin Statia
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 656-663 (2021)
Clinical and Translational Science
Clinical and Translational Science
In previous work, participants with a G970R mutation in cystic fibrosis transmembrane conductance regulator (CFTR) (c.2908G>C) had numerically lower sweat chloride responses during ivacaftor treatment than participants with other CFTR gating mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06e8eb19167efbcb66e67a1943cf51d
https://doi.org/10.1111/cts.12927
https://doi.org/10.1111/cts.12927
Autor:
Caroline J. Woo, Ayed Allawzi, Nicholas Clark, Neha Kaushal, Tim Efthymiou, Maike Thamsen, Jane Nguyen, Richard Wooster, James C. Sullivan
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 75:102134
Primary ciliary dyskinesia (PCD) is a respiratory disease caused by dysfunction of the cilia with currently no approved treatments. This predominantly autosomal recessive disease is caused by mutations in any one of over 50 genes involved in cilia fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf04a735c61ee2378cb98a89f4030cf
https://doi.org/10.1016/j.pupt.2022.102134
https://doi.org/10.1016/j.pupt.2022.102134
Autor:
Eric L Haseltine, Sandra De Meyer, Inge Dierynck, Doug J Bartels, Anne Ghys, Andrew Davis, Eileen Z Zhang, Ann M Tigges, Joan Spanks, Gaston Picchio, Tara L Kieffer, James C Sullivan
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 8, p e1003772 (2014)
For patients infected with hepatitis C virus (HCV), the combination of the direct-acting antiviral agent telaprevir, pegylated-interferon alfa (Peg-IFN), and ribavirin (RBV) significantly increases the chances of sustained virologic response (SVR) ov
Externí odkaz:
https://doaj.org/article/f5ba491c6dc148a48b13079d6909770f
Autor:
Eitan, Kerem, Malena, Cohen-Cymberknoh, Reuven, Tsabari, Michael, Wilschanski, Joel, Reiter, David, Shoseyov, Alex, Gileles-Hillel, Thea, Pugatsch, Jane C, Davies, Christopher, Short, Clare, Saunders, Cynthia, DeSouza, James C, Sullivan, Jamie R, Doyle, Keval, Chandarana, Nils, Kinnman
Publikováno v:
Annals of the American Thoracic Society. 18(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4186de30c40a4eb8d8658ae170513217
https://pubmed.ncbi.nlm.nih.gov/33095038
https://pubmed.ncbi.nlm.nih.gov/33095038
Autor:
Tara L Kieffer, Sandra De Meyer, Doug J Bartels, James C Sullivan, Eileen Z Zhang, Ann Tigges, Inge Dierynck, Joan Spanks, Jennifer Dorrian, Min Jiang, Bambang Adiwijaya, Anne Ghys, Maria Beumont, Robert S Kauffman, Nathalie Adda, Ira M Jacobson, Kenneth E Sherman, Stefan Zeuzem, Ann D Kwong, Gaston Picchio
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34372 (2012)
BackgroundIn patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone. However, genotypic cha
Externí odkaz:
https://doaj.org/article/1dbcfc20320f40f0bb077dc356b2c9f4
Autor:
Xiomara V Thomas, Joep de Bruijne, James C Sullivan, Tara L Kieffer, Cynthia K Y Ho, Sjoerd P Rebers, Michel de Vries, Hendrik W Reesink, Christine J Weegink, Richard Molenkamp, Janke Schinkel
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41191 (2012)
BACKGROUND & AIMS: Telaprevir, a hepatitis C virus NS3/4A protease inhibitor has significantly improved sustained viral response rates when given in combination with pegylated interferon alfa-2a and ribavirin, compared with current standard of care i
Externí odkaz:
https://doaj.org/article/2e4b8e9596954b95a4c8867de164ece3
Autor:
James C Sullivan, Francis S Wolenski, Adam M Reitzel, Courtney E French, Nikki Traylor-Knowles, Thomas D Gilmore, John R Finnerty
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7311 (2009)
NF-kappaB is an evolutionarily conserved transcription factor that controls the expression of genes involved in many key organismal processes, including innate immunity, development, and stress responses. NF-kappaB proteins contain a highly conserved
Externí odkaz:
https://doaj.org/article/4b2656f1902c45e289730b91d675f91b