Výsledky vyhledávání - "James C, Barrow"

Akademický článek

The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System

Publikováno v: Biomolecules, Vol 13, Iss 9, p 1317 (2023)

Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconve

Externí odkaz: https://doaj.org/article/dd1d22235ed14adba3ee0148abe7cb19

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Akademický článek

The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling

Autor: Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty

Publikováno v: Biomolecules, Vol 13, Iss 5, p 868 (2023)

Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed. We previously discovered that the inositol pyrophosphate biosynthetic enzyme IP6K1 is

Externí odkaz: https://doaj.org/article/2695fa91a3a24772ab51b42c8d89cc7f

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Akademický článek

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocyt

Externí odkaz: https://doaj.org/article/a91415f76f3b4ff6b00a1fb9ef500aaf

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Akademický článek

Inhibition of Catechol-O-methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice

Autor: Adrienne C. DeBrosse, Abigail M. Wheeler, James C. Barrow, Gregory V. Carr

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 14 (2020)

Effort-related choice (ERC) tasks allow animals to choose between high-value reinforcers that require high effort to obtain and low-value/low-effort reinforcers. Dopaminergic neuromodulation regulates ERC behavior. The enzyme catechol-O-methyltransfe

Externí odkaz: https://doaj.org/article/14f74712b1f94013be2cac3abfff26a9

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Akademický článek

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Autor: Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty

Publikováno v: Molecular Metabolism, Vol 5, Iss 10, Pp 903-917 (2016)

Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can

Externí odkaz: https://doaj.org/article/4a5698ea468148ab99f426b11943e5c3

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