Zobrazeno 1 - 10
of 151
pro vyhledávání: '"James C, Barrow"'
Autor:
Tyler Heitmann, James C. Barrow
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1317 (2023)
Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconve
Externí odkaz:
https://doaj.org/article/dd1d22235ed14adba3ee0148abe7cb19
Autor:
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 868 (2023)
Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed. We previously discovered that the inositol pyrophosphate biosynthetic enzyme IP6K1 is
Externí odkaz:
https://doaj.org/article/2695fa91a3a24772ab51b42c8d89cc7f
Autor:
Emily E. Burke, Joshua G. Chenoweth, Joo Heon Shin, Leonardo Collado-Torres, Suel-Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E. Straub, Daniel J. Hoeppner, Huei-Ying Chen, Alana Sellers, Kamel Shibbani, Gregory R. Hamersky, Marcelo Diaz Bustamante, BaDoi N. Phan, William S. Ulrich, Cristian Valencia, Amritha Jaishankar, Amanda J. Price, Anandita Rajpurohit, Stephen A. Semick, Roland W. Bürli, James C. Barrow, Daniel J. Hiler, Stephanie C. Page, Keri Martinowich, Thomas M. Hyde, Joel E. Kleinman, Karen F. Berman, Jose A. Apud, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Brady J. Maher, Ronald D. G. McKay, Andrew E. Jaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocyt
Externí odkaz:
https://doaj.org/article/a91415f76f3b4ff6b00a1fb9ef500aaf
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
Effort-related choice (ERC) tasks allow animals to choose between high-value reinforcers that require high effort to obtain and low-value/low-effort reinforcers. Dopaminergic neuromodulation regulates ERC behavior. The enzyme catechol-O-methyltransfe
Externí odkaz:
https://doaj.org/article/14f74712b1f94013be2cac3abfff26a9
Autor:
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 903-917 (2016)
Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can
Externí odkaz:
https://doaj.org/article/4a5698ea468148ab99f426b11943e5c3
Autor:
James C. Barrow, Craig W. Lindsley
Publikováno v:
Journal of Medicinal Chemistry. 66:4273-4274
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34df1c1bb26c5a43ca1674383b554449
https://doi.org/10.1021/acs.jmedchem.3c00514
https://doi.org/10.1021/acs.jmedchem.3c00514
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9c9e796fe82b22e3335d1c87078e8d
https://doi.org/10.1096/fasebj.2022.36.s1.l7751
https://doi.org/10.1096/fasebj.2022.36.s1.l7751
Autor:
Tony E. Dorado, Pablo de León, Asma Begum, Hester Liu, Daming Chen, N. V. Rajeshkumar, Romain Rey-Rodriguez, Coralie Hoareau-Aveilla, Chantal Alcouffe, Marikki Laiho, James C. Barrow
Publikováno v:
ACS Med Chem Lett
[Image: see text] RNA polymerase I (Pol I) transcribes ribosomal DNA (rDNA) into the 47S ribosomal RNA (rRNA) precursor. Further processing produces the 28S, 5.8S, and 18S rRNAs that are assembled into mature ribosomes. Many cancers exhibit higher Po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa34c25f3a8a65077683278c09bccd6
https://europepmc.org/articles/PMC9014438/
https://europepmc.org/articles/PMC9014438/
Autor:
Wenjun Fan, Hester Liu, Asma Begum, Stephanie Pitts, Brittany Ford, Tony Dorado, Pablo de Leon, Rajeshkumar NV, James C. Barrow, Marikki Laiho
Publikováno v:
Cancer Research. 82:2644-2644
RNA polymerase I inhibitors represent a new class of cancer therapeutics with potential application in many cancer types. By curbing the transcription of ribosomal RNAs they block the rate-limiting step in ribosome biogenesis and protein synthesis. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f14519b1bcfbf01d97921c7a1d32a9
https://doi.org/10.1158/1538-7445.am2022-2644
https://doi.org/10.1158/1538-7445.am2022-2644
Autor:
Ingrid P. Buchler, Michael Wormald, Gangling Liao, Michael DePasquale, Huijun Wei, James C. Barrow, Gregory V. Carr, Gongliang Zhang
Publikováno v:
ACS Chemical Neuroscience
The male rat adrenal pheochromocytoma cell-derived PC12 cell line can synthesize and release catecholamine neurotransmitters, and it has been widely used as a model system in cell biology and toxicology research. Catechol-O-methyltransferase (COMT) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559d974ab23a8f65cdbf708c6e8c3f7b
http://europepmc.org/articles/PMC7032882
http://europepmc.org/articles/PMC7032882