Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase

Autor: James Meyer, Kevin Salyers, Minghan Wang, Matthew P. Bourbeau, Yang Xu, Melissa Graham, Christopher H. Fotsch, John G. Allen, Wei Gu, Michael D. Bartberger, Mark R. Fielden, Murielle M. Véniant, Ki-Won Kim, James Busby, Aaron C. Siegmund, Renee Komorowski, Hong Shu

Publikováno v: Journal of Medicinal Chemistry. 56:10132-10141

Acetyl-CoA carboxylase (ACC) is a target of interest for the treatment of metabolic syndrome. Starting from a biphenyloxadiazole screening hit, a series of piperazine oxadiazole ACC inhibitors was developed. Initial pharmacokinetic liabilities of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9beafe68dbbbe77d4c7b20f9c669741
https://doi.org/10.1021/jm401601s

Expression, purification, and characterization of human acetyl-CoA carboxylase 2

Autor: Minghan Wang, Harvey Yamane, James Busby, Ki Won Kim, James Zondlo

Publikováno v: Protein Expression and Purification. 53:16-23

The full-length human acetyl-CoA carboxylase 1 (ACC1) was expressed and purified to homogeneity by two separate groups (Y.G. Gu, M. Weitzberg, R.F. Clark, X. Xu, Q. Li, T. Zhang, T.M. Hansen, G. Liu, Z. Xin, X. Wang, T. McNally, H. Camp, B.A. Beutel,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b18a063f6079858841ddd3e9eb89933
https://doi.org/10.1016/j.pep.2006.11.021

Cloning and Characterization of a Calcium-Sensing Receptor from the Hypercalcemic New Zealand White Rabbit Reveals Unaltered Responsiveness to Extracellular Calcium

Autor: Karen Krapcho, Robert Butters, James Busby, P. K. Nielsen, Steven Quinn, Paul K. Goldsmith, Shmuel Hurwitz, Ambrish Mithal, Naibedya Chattopadhyay, Craig P. Smith, Edward M. Brown, Olga Kifor, Mei Bai

Publikováno v: Journal of Bone and Mineral Research. 12:568-579

The extracellular Ca2+ (Ca(0)2+)-sensing receptor (CaR) recently cloned from mammalian parathyroid, kidney, brain, and thyroid plays a central role in maintaining near constancy of Ca(0)2+. We previously showed that the hypercalcemia normally present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f237630abfd7188e81c00bd890f03619
https://doi.org/10.1359/jbmr.1997.12.4.568

The selectivity of tyrosine 280 of human 11β-hydroxysteroid dehydrogenase type 1 in inhibitor binding

Autor: Minghan Wang, Rebecca Nybo, Stefan Svensson, Victor M. Castro, Fei Xiong, Trace Tsuruda, Zhulun Wang, Michelle Chen, James Busby, Ki Won Kim, Clarence Hale

Publikováno v: FEBS Letters. (5):995-999

11β-Hydroxysteroid dehydrogenase type 1 is a homodimer where the carboxyl terminus of one subunit covers the active site of the dimer partner. Based on the crystal structure with CHAPS, the carboxyl terminal tyrosine 280 (Y280) has been postulated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d341f9fc70330d1f41d4621931779dce

Journal of a recent visit to the principal vineyards of Spain and France. With some remarks on the very limited quantity of the finest wines produced throughout the world, and their consequent intrinsic value; an attempt to calculate the profits of cultivating the vine; a catalogue of the different varieties of grape; and an estimate of the profits of Malaga fruits; together with observations relative to the introduction of the vine into New South Wales

Autor: James Busby

Publikováno v: Journal of a recent visit to the principal vineyards of Spain and France. With some remarks on the very limited quantity of the finest wines produced throughout the world, and their consequent intrinsic value; an attempt to calculate the profits of cultivating the vine; a c By James Busby ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dee794a0ef4ca38376a526ce88ad028
https://doi.org/10.5962/bhl.title.34520