Zobrazeno 1 - 10
of 29
pro vyhledávání: '"James Bradner"'
Autor:
Emma J. Chory, Meng Wang, Michele Ceribelli, Aleksandra M Michalowska, Stefan Golas, Erin Beck, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Kelli M. Wilson, David Holland, Sanjay Divakaran, James Bradner, Javed Khan, Berkley E. Gryder, Craig J. Thomas, Benjamin Z. Stanton
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 193-201 (2023)
ABSTRACT: We report a comprehensive drug synergy study in acute myeloid leukemia (AML). In this work, we investigate a panel of cell lines spanning both MLL-rearranged and non-rearranged subtypes. The work comprises a resource for the community, with
Externí odkaz:
https://doaj.org/article/666943293cc94a44bc30dbda4865e32e
Autor:
Lena Hess, Verena Moos, Arnel A Lauber, Wolfgang Reiter, Michael Schuster, Natascha Hartl, Daniel Lackner, Thorina Boenke, Anna Koren, Paloma M Guzzardo, Brigitte Gundacker, Anna Riegler, Petra Vician, Claudia Miccolo, Susanna Leiter, Mahesh B Chandrasekharan, Terezia Vcelkova, Andrea Tanzer, Jun Qi Jun, James Bradner, Gerald Brosch, Markus Hartl, Christoph Bock, Tilmann Bürckstümmer, Stefan Kubicek, Susanna Chiocca, Srividya Bhaskara, Christian Seiser
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010376 (2022)
The class I histone deacetylases are essential regulators of cell fate decisions in health and disease. While pan- and class-specific HDAC inhibitors are available, these drugs do not allow a comprehensive understanding of individual HDAC function, o
Externí odkaz:
https://doaj.org/article/c86be04b9ac647019e3b6f55aae8c7bf
Autor:
Jerrica L. Breindel, Adam Skibinski, Maja Sedic, Ania Wronski-Campos, Wenhui Zhou, Patricia J. Keller, Joslyn Mills, James Bradner, Tamer Onder, Charlotte Kuperwasser
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 943-955 (2017)
Organogenesis and tissue development occur through sequential stepwise processes leading to increased lineage restriction and loss of pluripotency. An exception to this appears in the adult human breast, where rare variant epithelial cells exhibit pl
Externí odkaz:
https://doaj.org/article/15112164c4b44467a40b1d0c89dc317d
Autor:
Jennifer M. Spangle, Koen M. Dreijerink, Anna C. Groner, Hailing Cheng, Carolynn E. Ohlson, Jaime Reyes, Charles Y. Lin, James Bradner, Jean J. Zhao, Thomas M. Roberts, Myles Brown
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2692-2704 (2016)
Post-translational histone H3 modifications regulate transcriptional competence. The mechanisms by which the epigenome is regulated in response to oncogenic signaling remain unclear. Here we show that H3K4me3 is increased in breast tumors driven by a
Externí odkaz:
https://doaj.org/article/1182a581e724443e96a4492eb9735828
Autor:
Huachao Huang, Shuai Liu, Maxime Jean, Sydney Simpson, He Huang, Mark Merkley, Tsuyoshi Hayashi, Weili Kong, Irene Rodríguez-Sánchez, Xiaofeng Zhang, Hailemichael O. Yosief, Hongyu Miao, Jianwen Que, James J. Kobie, James Bradner, Netty G. Santoso, Wei Zhang, Jian Zhu
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
While combinatory antiretroviral therapy (cART) can effectively reduce HIV-1 viremia, it cannot eliminate HIV-1 infection. In the presence of cART, viral reservoirs remain latent, impeding the cure of HIV-1/AIDS. Recently, latency-reversing agents (L
Externí odkaz:
https://doaj.org/article/df67256a4ff2483891fd42f61b54032d
Autor:
Kwok-Kin Wong, Steven N. Quayle, James Bradner, Peter S. Hammerman, Simon S. Jones, Jerome Ritz, David A. Barbie, Mark M. Awad, Shiwei Han, Jennifer L. Guerriero, Haikuo Zhang, Neermala Poudel-Neupane, Guo-Cheng Yuan, Jessica Castrillon, Tiquella Warner-Hatten, Xiaoen Wang, Shengwu Liu, Yuyang Li, Ruben Dries, Christina Almonte, Amir R. Aref, Yusuke Kamihara, Patrick H. Lizotte, Yan Liu, Dennis O. Adeegbe
Effective therapies for non–small cell lung cancer (NSCLC) remain challenging despite an increasingly comprehensive understanding of somatically altered oncogenic pathways. It is now clear that therapeutic agents with potential to impact the tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa499687615cbd2999c1550ed59f546
https://doi.org/10.1158/2159-8290.c.6546529.v1
https://doi.org/10.1158/2159-8290.c.6546529.v1
Autor:
Kwok-Kin Wong, Steven N. Quayle, James Bradner, Peter S. Hammerman, Simon S. Jones, Jerome Ritz, David A. Barbie, Mark M. Awad, Shiwei Han, Jennifer L. Guerriero, Haikuo Zhang, Neermala Poudel-Neupane, Guo-Cheng Yuan, Jessica Castrillon, Tiquella Warner-Hatten, Xiaoen Wang, Shengwu Liu, Yuyang Li, Ruben Dries, Christina Almonte, Amir R. Aref, Yusuke Kamihara, Patrick H. Lizotte, Yan Liu, Dennis O. Adeegbe
Supplementary Table 1. HDAC inhibitors tested with healthy donor PBMCs and their biochemical potency (nM) across HDACs 1, 2, 3, and 6. Supplementary Table 2. Information for consented Non-small cell lung cancer (NSCLC) patients that underwent surgica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fa595cdbe70a04da18b07272eaa771
https://doi.org/10.1158/2159-8290.22531702
https://doi.org/10.1158/2159-8290.22531702
Autor:
Richard B.S. Roden, James Bradner, Ralph Mazitschek, Robert E. Bristow, Kwun C. Chan, Mei-Cheng Wang, Michael K. Lee, Antonio Santillan, Zhenhua Lin, Martina Bazzaro
Purpose: Elevated metabolic activity of ovarian cancer cells causes increased ubiquitin-proteasome-system (UPS) stress, resulting in their greater sensitivity to the toxic effects of proteasomal inhibition. The proteasomes and a potentially compensat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cccd57852286377c3743a4eb97a9582
https://doi.org/10.1158/1078-0432.c.6517240
https://doi.org/10.1158/1078-0432.c.6517240
Autor:
Richard B.S. Roden, James Bradner, Ralph Mazitschek, Robert E. Bristow, Kwun C. Chan, Mei-Cheng Wang, Michael K. Lee, Antonio Santillan, Zhenhua Lin, Martina Bazzaro
Supplementary Figures S1-S4 from Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6810dd9f4b8d6f82b01a07f3cb5cd666
https://doi.org/10.1158/1078-0432.22439833.v1
https://doi.org/10.1158/1078-0432.22439833.v1
Autor:
Hong Wu, James Bradner, Wei Guo, Consuelo Garcia, Harrison Chen, Anjelica Cardenas, Suzanne Schubbert
Primary human pediatric T-ALL samples show elevated levels of phospho-AKT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b6dbb7b03cc5144327d064d286771f
https://doi.org/10.1158/0008-5472.22404383.v1
https://doi.org/10.1158/0008-5472.22404383.v1