Zobrazeno 1 - 8 of 8 pro vyhledávání: '"James Brackley"'
1
Public health interventions in English local authorities: constructing the facts, (re)imagining the future
Autor: Penelope Tuck, Mark Exworthy, James Brackley
Publikováno v: Accounting, Auditing & Accountability Journal. 34:1664-1691
PurposeThis paper examines the contested value of healthy life and wellbeing in a context of severe austerity, exploring how the value of “Public Health” is constructed through and with material-discursive practices and accounting representations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d043bb3431787ab1441785a2563f233
https://doi.org/10.1108/aaaj-11-2019-4278
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3
[4+3] Cycloadditions of some allylic dioxolanes
Autor: Michael Harmata, Charles L. Barnes, James Brackley
Publikováno v: Tetrahedron Letters. 47:8151-8155
Four allylic dioxolanes were prepared and reacted with several dienes in the presence of Lewis acids, affording [4+3] cycloadducts. The reaction could be conducted with catalytic amounts of Lewis acid. The use of a chiral Lewis acid gave a cycloadduc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32ce244eadd271855e924f200969dc49
https://doi.org/10.1016/j.tetlet.2006.09.036
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4
Substituted dipiperidine alcohols as potent CCR2 antagonists
Autor: James Brackley, Monica Singer, Cuifen Hou, Michael P. Wachter, Druie Cavender, Michele Matheis, Mingde Xia, Meng Pan, Scott R. Pollack, Demong Duane E
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:3562-3564
The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC(50) values in the nanomolar or subnanomolar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e084a0c77db0c8f8366185d0b2ba1c3
https://doi.org/10.1016/j.bmcl.2008.05.010
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6
Synthesis, structure-activity relationship and in vivo antiinflammatory efficacy of substituted dipiperidines as CCR2 antagonists
Autor: Monica Singer, Ravi Malaviya, Nareshkumar F. Jain, Chrissy Gerchak, Meng Pan, Demong Duane E, Michael P. Wachter, Cuifen Hou, Druie Cavender, Michele Matheis, Gil Olini, Mingde Xia, James Brackley, Scott R. Pollack
Publikováno v: Journal of medicinal chemistry. 50(23)
A series of substituted dipiperidine compounds have been synthesized and identified as selective CCR2 antagonists. Combining the most favorable substituents led to the discovery of remarkably potent CCR2 antagonists displaying IC50 values in the nano
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39488e1d575b9efde2afb68953bba86
https://pubmed.ncbi.nlm.nih.gov/17929797
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7
Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists
Autor: Cuifen Hou, Monica Singer, Michele Matheis, Scott R. Pollack, Demong Duane E, Michael P. Wachter, Meng Pan, Druie Cavender, Mingde Xia, Gil Olini, James Brackley
Publikováno v: Bioorganicmedicinal chemistry letters. 17(21)
A series of phenyl piperidine derivatives possessing potent and selective CCR2 antagonist activity is reported. Structure–activity relationship (SAR) studies have established that incorporation of a second ring system adjacent to the aryl piperidin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ce8b33b0398e9a5915e41552b70d89
https://pubmed.ncbi.nlm.nih.gov/17869105
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