Levels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality

Autor: Nicola Curry, Amber Raja, James Beavis, Simon Stanworth, Paul Harrison

Publikováno v: Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-10 (2014)

Background: Microvesicles (MV) have been implicated in the development of thrombotic disease, such as acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF). Trauma patients are at increased risk of late thrombotic events, partic

Externí odkaz: https://doaj.org/article/27f0aa8415f84a6cbe73395b774cb9a0

Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype

Autor: Gael B. Morrow, Sarah Harper, James Beavis, P Bignell, Nicola Curry, Michael Laffan

Introduction A novel variant in the thrombomodulin (TM) gene, c.1487delC,p.(Pro496Argfs*10), referred to as Pro496Argfs*10, was identified in a family with an unexplained bleeding disorder. The Pro496Argfs*10 variant results in loss of the transmembr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c80593d6c1b5b5870c2d0cfa6d518d
http://hdl.handle.net/10044/1/84922

Coagulation status of critically ill patients with and without liver disease assessed using a novel thrombin generation analyser

Autor: Sarah Harper, Simon J. Stanworth, Michael Laffan, Gael B. Morrow, Nicola Curry, Peter J. Baker, James Beavis, Michael J.R. Desbourough

The liver synthesises the majority of pro‐ and anti‐ coagulant and fibrinolytic proteins, and during liver dysfunction synthesis of these proteins is reduced. The end point of conventional haemostatic tests, such as the prothrombin time (PT), occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b73f2cdf3cabad29ec5d3044fd24ac1
https://doi.org/10.1111/jth.14802

Idarucizumab for dabigatran overdose in a child

Autor: Susan Shapiro, Neha Bhatnagar, David Keeling, James Beavis, Asif Khan

Publikováno v: British Journal of Haematology. 180:457-459

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6f5826c1e9458428ebb4f3146aefa7a
https://doi.org/10.1111/bjh.14371

Levels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality

Autor: Simon J. Stanworth, Paul Harrison, Amber Raja, Nicola Curry, James Beavis

Publikováno v: Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-10 (2014)
Journal of Extracellular Vesicles; Vol 3 (2014) incl supplements

Background : Microvesicles (MV) have been implicated in the development of thrombotic disease, such as acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF). Trauma patients are at increased risk of late thrombotic events, parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac48d4c8ac2fa02be780116933a0d76
https://pubmed.ncbi.nlm.nih.gov/26077419