Výsledky vyhledávání - "James Barsoum"

Akademický článek

Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.

Autor: Yumiko Wada, Irma Cardinale, Artemis Khatcherian, John Chu, Aaron B Kantor, Alice B Gottlieb, Noriaki Tatsuta, Eric Jacobson, James Barsoum, James G Krueger

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35069 (2012)

Psoriasis is characterized by hyperplasia of the epidermis and infiltration of leukocytes into both the dermis and epidermis. IL-23, a key cytokine that induces T(H)17 cells, has been found to play a critical role in the pathogenesis of psoriasis. Ap

Externí odkaz: https://doaj.org/article/f4f65f27070148008373e4e6ff80dff7

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Akademický článek

Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.

Autor: David A Proia, Kevin P Foley, Tim Korbut, Jim Sang, Don Smith, Richard C Bates, Yuan Liu, Alex F Rosenberg, Dan Zhou, Keizo Koya, James Barsoum, Ronald K Blackman

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18552 (2011)

There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the constitutive activation of STAT transcription factors and lead to oncogenic growth. JAK kinase

Externí odkaz: https://doaj.org/article/5f8979a9202f493f95717a8dd14439d5

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Akademický článek

Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer.

Autor: Cheryl A London, Misty D Bear, Jennifer McCleese, Kevin P Foley, Reji Paalangara, Takayo Inoue, Weiwen Ying, James Barsoum

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27018 (2011)

The novel water soluble compound STA-1474 is metabolized to ganetespib (formerly STA-9090), a potent HSP90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibit tumor growth in the setting of murine xenografts. The purpose o

Externí odkaz: https://doaj.org/article/34d733f7e1614f0cb887dd597b2ff230

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