Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James Badger Wing"'
Autor:
Ryo Morita, Ritsuko Kubota-Koketsu, Xiuyuan Lu, Tadahiro Sasaki, Emi E. Nakayama, Yu-chen Liu, Daisuke Okuzaki, Daisuke Motooka, James Badger Wing, Yasunori Fujikawa, Yuji Ichida, Kiyoko Amo, Tetsushi Goto, Junichi Hara, Michinori Shirano, Sho Yamasaki, Tatsuo Shioda
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106685- (2023)
Summary: A 25-year-old patient with a primary immunodeficiency lacking immunoglobulin production experienced a relapse after a 239-day period of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Viral genetic sequenci
Externí odkaz:
https://doaj.org/article/f0e08f94d7854578b413062f38f95992
Autor:
Takayoshi Morita, Yoshihito Shima, James Badger Wing, Shimon Sakaguchi, Atsushi Ogata, Atsushi Kumanogoh
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162306 (2016)
Regulatory T cells (Tregs) have important functions in peripheral immune tolerance. Dysfunction of Tregs is considered to be a pivotal cause of autoimmune diseases, including rheumatoid arthritis (RA). However, previous reports describing the proport
Externí odkaz:
https://doaj.org/article/e0f92b2b94544ae78bca8fdb94cd9f94
Autor:
James Badger Wing, Shimon eSakaguchi
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Foxp3+ regulatory T-cells (Tregs) are a constitutively immunosuppressive cell type critical for the control of autoimmunity and inflammatory pathology. A range of mechanisms of Treg suppression have been identified and it has not always been clear ho
Externí odkaz:
https://doaj.org/article/e2a7dcb5021b4b0e9a3d4f1ab6f4212d
Autor:
Jonas Nørskov Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Shimon Sakaguchi, Atsushi Kumanogoh, Yukinori Okada, James Badger Wing
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Sex-biased humoral immune responses to COVID-19 patients have been observed, but the cellular basis for this is not understood. Using single-cell proteomics by mass cytometry, we find disrupted regulation of humoral immunity in COVID-19 patients, wit
Autor:
Takehito, Yokoi, Mari, Murakami, Takako, Kihara, Shigeto, Seno, Mitsuru, Arase, James Badger, Wing, Jonas Nørskov, Søndergaard, Ryuichi, Kuwahara, Tomohiro, Minagawa, Eri, Oguro-Igashira, Daisuke, Motooka, Daisuke, Okuzaki, Ryota, Mori, Atsuyo, Ikeda, Yuki, Sekido, Takahiro, Amano, Hideki, Iijima, Keiichi, Ozono, Tsunekazu, Mizushima, Seiichi, Hirota, Hiroki, Ikeuchi, Kiyoshi, Takeda
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
T cells differentiate into highly diverse subsets and display plasticity depending on the environment. Although lymphocytes are key mediators of inflammation, functional specialization of T cells in inflammatory bowel disease (IBD) has not been effec
Autor:
Kiyoshi Minohara, Masaki Imai, Takuma Matoba, James Badger Wing, Hiroaki Shime, Mizuyu Odanaka, Ryuta Uraki, Daisuke Kawakita, Tatsuya Toyama, Satoru Takahashi, Akimichi Morita, Shingo Murakami, Naganari Ohkura, Shimon Sakaguchi, Shinichi Iwasaki, Sayuri Yamazaki
Publikováno v:
Cancer science.
We previously reported that regulatory T (Treg) cells expressing CTLA-4 on the cell surface are abundant in head and neck squamous cell carcinoma (HNSCC). The role of expanded Treg cells in the tumor microenvironment of HNSCC remains unclear. In this
Autor:
Eleni P, Mimitou, Caleb A, Lareau, Kelvin Y, Chen, Andre L, Zorzetto-Fernandes, Yuhan, Hao, Yusuke, Takeshima, Wendy, Luo, Tse-Shun, Huang, Bertrand Z, Yeung, Efthymia, Papalexi, Pratiksha I, Thakore, Tatsuya, Kibayashi, James Badger, Wing, Mayu, Hata, Rahul, Satija, Kristopher L, Nazor, Shimon, Sakaguchi, Leif S, Ludwig, Vijay G, Sankaran, Aviv, Regev, Peter, Smibert
Publikováno v:
Nature biotechnology. 39(10)
Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling by sequencing (ASAP-seq), a t
Publikováno v:
Advances in experimental medicine and biology. 1189
Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to
Publikováno v:
The Journal of Immunology. 204:228.8-228.8
Regulatory T cells (Tregs) are responsible for the maintenance of immune homeostasis. They express the coinhibitory receptor CTLA-4 in high quantities, whose loss causes severe systemic autoinflammation in both mice and humans. CTLA-4 limits the expr
Autor:
James Badger, Wing, Yohko, Kitagawa, Michela, Locci, Hannah, Hume, Christopher, Tay, Takayoshi, Morita, Yujiro, Kidani, Kyoko, Matsuda, Takeshi, Inoue, Tomohiro, Kurosaki, Shane, Crotty, Cevayir, Coban, Naganari, Ohkura, Shimon, Sakaguchi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(31)
T-follicular regulatory (Tfr) cells, a subset of Foxp3-expressing regulatory T (Treg) cells, have a critical role in the control of antibody responses. Whereas Treg cells express CD25 and are dependent on IL-2, Tfr cells also express the transcriptio