Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James B. Wiesner"'
Autor:
Megumi Tsuchiya, James B. Wiesner, Masami Nakane, Atsushi Nagahisa, Michael C. Matelich, Matthew Allan, Robert H Lemus, Brett C. Bookser, Mark D. Erion, Bheemarao G. Ugarkar
Publikováno v:
Journal of Medicinal Chemistry. 48:7808-7820
4-(Phenylamino)-5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 1 and related compounds known as "diaryltubercidin" analogues are potent inhibitors of adenosine kinase (AK) and are orally active in animal models of pain such as the
Autor:
and Juergen M. Schanzer, James B. Wiesner, Jay DaRe, Joseph J. Kopcho, Mark D. Erion, Angelo J. Castellino, Bheemarao G. Ugarkar
Publikováno v:
Journal of Medicinal Chemistry. 43:2883-2893
Adenosine receptor agonists produce a wide variety of therapeutically useful pharmacologies. However, to date they have failed to undergo successful clinical development due to dose-limiting side effects. Adenosine kinase inhibitors (AKIs) represent
Autor:
Ross Dixon, Mark D. Erion, James R. Appleman, Jay DaRe, James M. Fujitaki, Angelo J. Castellino, James B. Wiesner, Bheemarao G. Ugarkar
Publikováno v:
Nucleosides and Nucleotides. 16:1013-1021
The pyrrolopyrimidine nucleoside GP3269 (12) was shown to be a potent and selective inhibitor of human adenosine kinase (IC50 = 11 nM) and to exhibit anticonvulsant activity in rats after oral administration. Synthesis of GP3269 was accomplished in 4
Autor:
James M. Fujitaki, Angelo J. Castellino, Ross Dixon, Mark D. Erion, James R. Appleman, James B. Wiesner, Bheemarao G. Ugarkar, Jay DaRe
Publikováno v:
ChemInform. 29
The pyrrolopyrimidine nucleoside GP3269 (12) was shown to be a potent and selective inhibitor of human adenosine kinase (IC50 = 11 nM) and to exhibit anticonvulsant activity in rats after oral administration. Synthesis of GP3269 was accomplished in 4
Autor:
Serge H. Boyer, Mark D. Erion, Bheemarao G. Ugarkar, Joel Solbach, Rohan Mendonca, Joseph J. Kopcho, Atsushi Nagahisa, and James B. Wiesner, Michael C. Matelich, Megumi Tsuchiya, Kristin Ollis, Jorge Gomez-Galeno, Masami Nakane
Publikováno v:
Journal of medicinal chemistry. 48(20)
Adenosine is an endogenous neuromodulator that when produced in the central and the peripheral nervous systems has anticonvulsant, anti-inflammatory, and analgesic properties. However, efforts to use adenosine receptor agonists are plagued by dose-li
Autor:
Bheemarao G. Ugarkar, Angelo J. Castellino, Jay M. DaRe, Joseph J. Kopcho, James B. Wiesner, Juergen M. Schanzer, Mark D. Erion
Publikováno v:
Journal of medicinal chemistry. 43(15)
In the preceding article (Ugarkar et al. J. Med. Chem. 2000, 43) we reported that analogues of tubercidin are potent adenosine kinase (AK) inhibitors with antiseizure activity in the rat maximum electroshock (MES) model. Despite the discovery of seve
Publikováno v:
Purine and Pyrimidine Metabolism in Man VIII ISBN: 9781461361053
In the central nervous system (CNS), adenosine is proposed to play a role as a neuromodulator. One function is to provide negative feedback in response to increased activation of neurons. These effects are of importance for the “normal” physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29d9e6f5951fdc6e2c73460e2375fc9
https://doi.org/10.1007/978-1-4615-2584-4_92
https://doi.org/10.1007/978-1-4615-2584-4_92
Autor:
James B. Wiesner, Robert L. Moss
Publikováno v:
Life Sciences. 34:1455-1462
Endogenous opioid peptides have been implicated in the control of copulatory behavior of the male rat. In order to assess the possible role of opioids in modulation of sexual receptivity in the female rat, lordosis behavior of ovariectomized (OVX) st
Publikováno v:
Life Sciences. 34:1463-1473
A number of sites have been hypothesized as loci at which opioid substances act to alter the secretion of luteinizing hormone (LH) and prolactin (PRL) (1-8). The aim of the present study was to determine the site(s) at which the opioid peptide beta-e
Autor:
James B. Wiesner, Robert L. Moss
Publikováno v:
Pharmacology Biochemistry and Behavior. 24:1235-1239
Open field behavior was observed in conjunction with mating behavior to discern whether the effect of intraventricular (ICV) beta-endorphin (beta-END) on sexual behavior may be secondary to akinesia. Three groups of ovariectomized, estrogen-progester